INT76814

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 6.11
Pain Relevance 8.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tacr1) plasma membrane (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
AMs 8
urothelial cells 4
spinal cord 2
nerve 2
lamina 2
Tacr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 82 99.98 Very High Very High Very High
cINOD 10 99.96 Very High Very High Very High
substance P 222 99.92 Very High Very High Very High
Spinal cord 23 99.40 Very High Very High Very High
projection neuron 3 99.36 Very High Very High Very High
Pain 11 98.92 Very High Very High Very High
nociceptor 3 98.92 Very High Very High Very High
antagonist 30 98.48 Very High Very High Very High
c fibre 4 98.32 Very High Very High Very High
Dorsal horn 11 97.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 85 99.98 Very High Very High Very High
Nociception 28 99.84 Very High Very High Very High
Nervous System Injury 6 99.58 Very High Very High Very High
Hyperalgesia 6 98.74 Very High Very High Very High
Colitis 10 98.64 Very High Very High Very High
Bladder Cancer 2 98.08 Very High Very High Very High
Injury 5 98.00 Very High Very High Very High
Neuropathic Pain 9 92.80 High High
Cystitis 30 90.64 High High
Pain 15 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Role of neurogenic substance P in overexpression of alveolar macrophages' neurokinin 1 receptor in mice exposed to cigarette smoke.
Positive_regulation (overexpression) of Gene_expression (overexpression) of neurokinin 1 receptor in alveolar macrophages associated with substance p
1) Confidence 0.69 Published 2010 Journal Exp. Lung Res. Section Title Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.60
Tacr1 gene expression was also increased in mice treated for 3 h with PPT revealing the participation of ER?.
Positive_regulation (increased) of Gene_expression (expression) of Tacr1
2) Confidence 0.68 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.17 Pain Relevance 0.25
Formalin- or adjuvant-induced peripheral inflammation increases neurokinin-1 receptor gene expression in the mouse.
Positive_regulation (increases) of Gene_expression (expression) of neurokinin-1 receptor associated with inflammation
3) Confidence 0.66 Published 2003 Journal Brain Res. Section Title Doc Link 12535787 Disease Relevance 0.63 Pain Relevance 0.95
This supports the hypothesis that increased NK-1 receptor gene expression contributes to the development and maintenance of a hyperalgesic state.
Positive_regulation (increased) of Gene_expression (expression) of NK-1 receptor gene associated with hyperalgesia
4) Confidence 0.66 Published 2003 Journal Brain Res. Section Abstract Doc Link 12535787 Disease Relevance 0.44 Pain Relevance 0.31
These results confirm that mice are hyperalgesic at late time points after formalin or adjuvant injection when NK-1 receptor gene expression is elevated in the dorsal spinal cord.
Positive_regulation (elevated) of Gene_expression (expression) of NK-1 receptor gene in spinal cord associated with hyperalgesia and spinal cord
5) Confidence 0.66 Published 2003 Journal Brain Res. Section Abstract Doc Link 12535787 Disease Relevance 0.41 Pain Relevance 0.35
NF-kappaB activity is correlated with bladder cancer [50-52] and bladder urothelial cells respond to insults with a translocation of NF-kappaB [53] leading ultimately to an increased NK1R expression [54].
Positive_regulation (leading) of Gene_expression (expression) of NK1R in urothelial cells associated with bladder cancer
6) Confidence 0.53 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.51 Pain Relevance 0.28
We observed a reduction of SP immunoreactivity in the superficial dorsal horn on the injured side at 7 and 14, but not at 3 or 70 days after the nerve injury, and we observed an increase of NK-1 receptor expression at 3, 7, 14 and 42, but not at 70 days after the injury.
Positive_regulation (increase) of Gene_expression (expression) of NK-1 receptor in nerve associated with nervous system injury, injury, dorsal horn and substance p
7) Confidence 0.52 Published 1998 Journal Pain Section Abstract Doc Link 9696476 Disease Relevance 1.34 Pain Relevance 1.12
Because CS could stimulate pulmonary C-fibers (PCFs) to release SP, we asked whether this neurogenic SP was responsible for AMs' NK1R overexpression during CS.
Spec (whether) Positive_regulation (overexpression) of Gene_expression (overexpression) of NK1R in AMs associated with c fibre and substance p
8) Confidence 0.46 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.52
Tacr1 expression was increased in mice treated for 3 h with E2 or PPT (Fig. 3A).
Positive_regulation (increased) of Gene_expression (expression) of Tacr1
9) Confidence 0.46 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0
The nociceptive function of SP is mainly attributed to the activation of NK1 receptors (NK1R) that are expressed on nociceptive projection neurons located in lamina I of the dorsal horn [8,11,12].
Positive_regulation (activation) of Gene_expression (expressed) of NK1R in lamina associated with nociception, dorsal horn, projection neuron and substance p
10) Confidence 0.45 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0.60 Pain Relevance 1.01
IL-10 also down-modulated ongoing NK-1R expression.
Positive_regulation (ongoing) of Gene_expression (expression) of NK-1R
11) Confidence 0.44 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14500676 Disease Relevance 0.81 Pain Relevance 0.84
Our results suggest that CS produces AMs' NK1R overexpression primarily by both promoting neurogenic SP release and synergizing NK1R response to neurogenic SP largely via activating NF-kappaB pathway.
Positive_regulation (overexpression) of Gene_expression (produces) of NK1R in AMs associated with substance p
12) Confidence 0.44 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.61
Our results suggest that CS produces AMs' NK1R overexpression primarily by both promoting neurogenic SP release and synergizing NK1R response to neurogenic SP largely via activating NF-kappaB pathway.
Positive_regulation (produces) of Gene_expression (produces) of NK1R in AMs associated with substance p
13) Confidence 0.44 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.61
LP T cells from IL-10(-/-) mice expressed NK-1R and produced IFN-gamma only after NSAID treatment and induction of colitis.
Positive_regulation (after) of Gene_expression (expressed) of NK-1R in T cells associated with colitis and cinod
14) Confidence 0.41 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14500676 Disease Relevance 0.71 Pain Relevance 0.71
NF-kappaB activity is correlated with bladder cancer [50-52] and bladder urothelial cells respond to insults with a translocation of NF-kappaB [53] leading ultimately to an increased NK1R expression [54].
Positive_regulation (increased) of Gene_expression (expression) of NK1R in urothelial cells associated with bladder cancer
15) Confidence 0.36 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.51 Pain Relevance 0.28

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