INT76815

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Context Info
Confidence 0.12
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.81
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
urinary bladder 2
neurons 2
nerve 2
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 249 100.00 Very High Very High Very High
calcitonin gene related peptide 11 100.00 Very High Very High Very High
Neuropeptide 5 100.00 Very High Very High Very High
Spinal cord 4 99.68 Very High Very High Very High
Inflammation 30 99.20 Very High Very High Very High
allodynia 6 97.32 Very High Very High Very High
interstitial cystitis 2 94.24 High High
antagonist 5 93.84 High High
Sciatic nerve 3 93.64 High High
withdrawal 1 93.60 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 6 99.82 Very High Very High Very High
Cystitis 15 99.56 Very High Very High Very High
INFLAMMATION 35 99.20 Very High Very High Very High
Neuropathic Pain 8 97.32 Very High Very High Very High
Abnormal Reflex 3 95.84 Very High Very High Very High
Syndrome 1 94.64 High High
Overactive Bladder 7 94.48 High High
Interstitial Cystitis 2 94.24 High High
Ganglion Cysts 85 91.20 High High
Pain 9 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also used immunocytochemistry to analyze nerve injury-induced changes in substance P (SP) and NK-1 (SP) receptor expression in the spinal cord.
Regulation (changes) of Gene_expression (expression) of SP in nerve associated with nervous system injury, spinal cord and substance p
1) Confidence 0.12 Published 1998 Journal Pain Section Abstract Doc Link 9696476 Disease Relevance 1.29 Pain Relevance 1.06
In addition, changes in SP expression following cystitis may contribute to the altered visceral sensation (allodynia) and/or urinary bladder hyperreflexia in the clinical syndrome, interstitial cystitis [4].
Regulation (changes) of Gene_expression (expression) of SP in urinary bladder associated with allodynia, syndrome, abnormal reflex, cystitis, interstitial cystitis and substance p
2) Confidence 0.06 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 1.97 Pain Relevance 0.83
In contrast, expression levels of mRNA for the Runx1-independent neuropeptides CGRP and Substance P/Tachykinin 1 (SP/Tac1) were little changed (Figure 3B), consistent with past results [16,17].
Neg (little) Regulation (changed) of Gene_expression (expression) of SP associated with calcitonin gene related peptide, neuropeptide and substance p
3) Confidence 0.06 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.55 Pain Relevance 1.11
Effects of SP analogs on single neurons
Regulation (Effects) of Gene_expression (analogs) of SP in neurons associated with substance p
4) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.65

General Comments

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