INT76834

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.76
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
plasma 2
blood 2
paw 2
Edn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 6 99.58 Very High Very High Very High
agonist 5 98.64 Very High Very High Very High
qutenza 8 98.56 Very High Very High Very High
antagonist 14 92.12 High High
guanethidine 2 87.12 High High
anesthesia 3 78.88 Quite High
Inflammation 15 78.56 Quite High
IPN 2 63.12 Quite High
nociceptor 2 60.36 Quite High
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Hyperalgesia 9 99.58 Very High Very High Very High
Nociception 4 92.96 High High
Hypoxia 3 91.76 High High
Paralysis 6 87.08 High High
INFLAMMATION 9 78.56 Quite High
Hyperoxia 162 58.20 Quite High
Arthropathy 2 58.16 Quite High
Lung Injury 15 50.00 Quite Low
Body Weight 3 16.60 Low Low
Toxicity 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Measurement of ET-1 levels in blood
Negative_regulation (Measurement) of Gene_expression (levels) of ET-1 in blood
1) Confidence 0.43 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.24 Pain Relevance 0.06
The ET-1 level in the plasma was then determined by an Elisa technique (Human Endothelin Immunoassay, Catalog number QET00B, R&D Systems Inc.
Spec (determined) Negative_regulation (determined) of Gene_expression (level) of ET-1 in plasma
2) Confidence 0.43 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.16 Pain Relevance 0.08
Hyperalgesia induced by 5-HT was abolished by simultaneous injection of endothelin-1 or the endothelin ET(B) receptor agonist IRL 1620 (each at 30 pmol/paw).
Negative_regulation (abolished) of Gene_expression (injection) of endothelin-1 in paw associated with hyperalgesia and agonist
3) Confidence 0.41 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9698200 Disease Relevance 0.81 Pain Relevance 0.95
Following ET-1 injection, Zrs was measured at 30 s, and then at 1-min intervals until 6 min, and at 2 min intervals until 20 min.
Negative_regulation (measured) of Gene_expression (injection) of ET-1
4) Confidence 0.37 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0 Pain Relevance 0
The OVA challenge-induced IFN-gamma and ET-1 productions were inhibited in IL-18(-/-) immunized mice, as well as ET-1 production in IFN-gamma(-/-) immunized mice.
Negative_regulation (inhibited) of Gene_expression (productions) of ET-1
5) Confidence 0.30 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17194566 Disease Relevance 0.27 Pain Relevance 0.39
The OVA challenge-induced IFN-gamma and ET-1 productions were inhibited in IL-18(-/-) immunized mice, as well as ET-1 production in IFN-gamma(-/-) immunized mice.
Negative_regulation (inhibited) of Gene_expression (production) of ET-1
6) Confidence 0.30 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17194566 Disease Relevance 0.28 Pain Relevance 0.39

General Comments

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