INT76836

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Context Info
Confidence 0.55
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 2.65
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ednra) plasma membrane (Ednra) signal transducer activity (Ednra)
Anatomy Link Frequency
neuronal 2
plasma 1
paw 1
lung 1
cerebellum 1
Ednra (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 3 100.00 Very High Very High Very High
Hyperalgesia 14 99.96 Very High Very High Very High
Inflammation 16 97.92 Very High Very High Very High
Glutamate 196 96.92 Very High Very High Very High
Neurotransmitter 36 96.48 Very High Very High Very High
Pain 1 94.68 High High
qutenza 8 93.40 High High
Substantia nigra 4 91.16 High High
Thalamus 12 90.32 High High
antagonist 13 89.84 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 18 99.96 Very High Very High Very High
INFLAMMATION 13 97.92 Very High Very High Very High
Pneumonia 2 95.98 Very High Very High Very High
Hyperoxia 54 95.34 Very High Very High Very High
Pain 1 94.68 High High
Neuropathic Pain 1 94.00 High High
Poisoning 8 93.32 High High
Stress 17 91.08 High High
Injury 4 88.08 High High
Cancer 53 81.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the case of inflammatory hyperalgesia, some previous papers have pointed towards the involvement of ETB receptors, although the stimulation of ETA receptors seems to participate in the development of the inflammatory reaction.
Positive_regulation (stimulation) of ETA associated with hyperalgesia and inflammation
1) Confidence 0.55 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14661069 Disease Relevance 1.02 Pain Relevance 0.78
Since hyperoxia also leads to lung inflammation, it is possible that the diminished airway responses are due to the decreased density of the ETB receptors, whereas the enhanced parenchymal responsiveness may be attributed (at least in part) to the upregulation of the ETA receptors in the lung tissue.
Positive_regulation (upregulation) of ETA in lung associated with inflammation, hyperoxia and pneumonia
2) Confidence 0.17 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.50 Pain Relevance 0.13
The selective endothelin ET(B) receptor agonists sarafotoxin S6c (< or = 30 pmol/paw) and IRL 1620 (i.e., Suc[Glu9,Ala11,15]endothelin-1-(10-21); < or = 100 pmol/paw) failed to induce hyperalgesia.
Neg (failed) Positive_regulation (induce) of endothelin ET in paw associated with hyperalgesia and agonist
3) Confidence 0.12 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9698200 Disease Relevance 0.53 Pain Relevance 0.79
On average, as determined within 1 min after the first membrane current change was detected, the increase in plasma transmembrane current due to ET was ?
Positive_regulation (increase) of ET in plasma
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0.03
To analyze the effect of ET on neurotransmission (i.e. neuronal network activity and neurotransmitter release), we used cerebellar slices cultured for 2–3 weeks in vitro, which form a simplified cerebellar neuronal network, and are thin enough (few layers of neurons) to allow access of ET to all the neurons present in the slice, which is not the case in acute slices.
Positive_regulation (access) of ET in neuronal associated with neurotransmitter
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.06 Pain Relevance 0.26
The TTX experiments suggest that the ET-stimulated increase in synaptic activity is due to an enhanced activity in the neuronal network.
Positive_regulation (increase) of ET in neuronal
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0.37
The marked staining observed in the cerebellum is consistent with the previous reports that the cerebellum is a predilection site for the induction of ET damage [4], [18], [22].
Positive_regulation (induction) of ET in cerebellum
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.18 Pain Relevance 0.30
Data from our previous study revealed that pharmacological
               levels of leptin (50 and 100 nM) compromised cardiac contractile function and
               intracellular Ca2+ homeostasis through an ET-1 receptor-/NADPH
               oxidase-dependent accumulation of reactive oxygen species [22]. 
Positive_regulation (accumulation) of ET-1 receptor
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.17 Pain Relevance 0
Recombinant scFv(FRP5)-ETA was produced as an experimental drug under Good Manufacturing Practice conditions and was kindly provided by Ciba Geigy AG (Basel, Switzerland).
Positive_regulation (provided) of ETA
9) Confidence 0.02 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1242130 Disease Relevance 0.20 Pain Relevance 0.07

General Comments

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