INT76860

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Context Info
Confidence 0.65
First Reported 1997
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 32
Total Number 38
Disease Relevance 37.14
Pain Relevance 9.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (HSPG2) small molecule metabolic process (HSPG2) extracellular region (HSPG2)
plasma membrane (HSPG2) extracellular matrix organization (HSPG2) lipid metabolic process (HSPG2)
Anatomy Link Frequency
endothelial cells 3
external 1
periodontium 1
platelets 1
oocytes 1
HSPG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hyperalgesia 1 100.00 Very High Very High Very High
rheumatoid arthritis 506 99.68 Very High Very High Very High
Inflammation 116 99.62 Very High Very High Very High
antiepileptic Drug 24 99.54 Very High Very High Very High
Arthritis 250 99.40 Very High Very High Very High
nociceptor 1 98.56 Very High Very High Very High
corticosteroid 84 97.76 Very High Very High Very High
carbamazepine 115 97.68 Very High Very High Very High
Central nervous system 9 97.56 Very High Very High Very High
opioid receptor 2 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Staphylococcus Infection 987 100.00 Very High Very High Very High
Bullous Skin Disease 768 100.00 Very High Very High Very High
Syndrome 305 100.00 Very High Very High Very High
Urticaria 3 100.00 Very High Very High Very High
Hyperalgesia 1 100.00 Very High Very High Very High
Acute Generalized Exanthematous Pustulosis 66 99.78 Very High Very High Very High
Rheumatoid Arthritis 596 99.68 Very High Very High Very High
Hepatotoxicity 15 99.64 Very High Very High Very High
Alzheimer's Dementia 9 99.64 Very High Very High Very High
INFLAMMATION 130 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reductions in MFI values for p-AKT, p-p38, p-JNK, p-PLC?
Gene_expression (Reductions) of PLC
1) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0 Pain Relevance 0.47
They elicited Ca(2+)-activated Cl(-) currents in oocytes coexpressing these receptors with the Gbetagamma-activated form of phospholipase C (PLC)-beta2 but not with PLC-beta1.
Neg (not) Gene_expression (coexpressing) of PLC in oocytes
2) Confidence 0.65 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15151902 Disease Relevance 0.14 Pain Relevance 0.20
Also, in a behavioral model, cAMP produced mechanical hyperalgesia (tenderness) through Epac, PLC/PLD, and PKCepsilon.
Gene_expression (produced) of PLC associated with hyperalgesia
3) Confidence 0.65 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15987941 Disease Relevance 0.53 Pain Relevance 0.38
Yoon et al. [24] reviewed 46 patients having PLC reconstruction, comparing the clinical results of PLC sling procedure with an anatomical PLC reconstruction.
Gene_expression (reconstruction) of PLC
4) Confidence 0.59 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2896579 Disease Relevance 0.92 Pain Relevance 0
Following McGuire’s technique [9], a single femoral tunnel was performed on four patients, while in the remaining six patients, the reconstruction of the PLC was performed with a double femoral tunnel, as described by Arciero [10] (Figs. 1, 2).Fig. 1Single femoral tunnel technique, as described by McGuireFig. 2Double femoral tunnel following Arciero’s technique
Gene_expression (reconstruction) of PLC
5) Confidence 0.59 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2896579 Disease Relevance 0.44 Pain Relevance 0.13
In a biomechanical study, Markolf et al. [13] observed that, using two different surgical PLC reconstructions (FCL + PT versus FCL + PFL), the amount of external rotation was equivalent in both techniques.
Gene_expression (reconstructions) of PLC in external
6) Confidence 0.59 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2896579 Disease Relevance 0.38 Pain Relevance 0
Recently, mutations in the gene Perlecan (HSPG2) encoding the protein heparan sulfate proteoglycan 2, have been found to be responsible for this condition.
Gene_expression (encoding) of Perlecan
7) Confidence 0.58 Published 2003 Journal BMC Neurol Section Body Doc Link PMC166146 Disease Relevance 1.07 Pain Relevance 0
Levetiracetam is not known to produce SJS, EM or TEN when administered alone or with concurrent radiation therapy.
Gene_expression (produce) of SJS associated with syndrome and bullous skin disease
8) Confidence 0.52 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2894848 Disease Relevance 0.94 Pain Relevance 0.27
These mutations result in significant reduction in the production of the wild-type (normal) protein encoded by Perlecan (figure 2).
Gene_expression (production) of Perlecan
9) Confidence 0.45 Published 2003 Journal BMC Neurol Section Body Doc Link PMC166146 Disease Relevance 0.79 Pain Relevance 0.16
Similarly the level of HSPG expression was lowest in normal synovia and increased in OA, followed by RA and PsA.
Gene_expression (expression) of HSPG associated with rheumatoid arthritis, osteoarthritis and arthritis
10) Confidence 0.36 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 1.72 Pain Relevance 0.78
There was no obvious difference between the different types of chronic inflammation in terms of their HSPG expression, since RA and PsA showed an identical pattern.
Gene_expression (expression) of HSPG associated with inflammation, rheumatoid arthritis and arthritis
11) Confidence 0.36 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 1.60 Pain Relevance 0.74
The major difference in HSPG expression between the synovial samples appeared related to the degree of histological inflammation (tables 1 and 2).
Gene_expression (expression) of HSPG associated with inflammation
12) Confidence 0.36 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 1.64 Pain Relevance 0.72
The chronology of administration of a culprit drug, or time between first administration and development of SJS/TEN, is between 1 and 4 weeks in the majority of cases.
Gene_expression (development) of SJS associated with staphylococcus infection and bullous skin disease
13) Confidence 0.35 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.47 Pain Relevance 0.08
It should be noted, however, that the Nikolsky sign is not specific for SJS/TEN.
Neg (not) Gene_expression (specific) of SJS associated with staphylococcus infection and bullous skin disease
14) Confidence 0.35 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.44 Pain Relevance 0.12
Subsequently, a strong association between SJS/TEN and HLA-B*5801 was found in Japanese patients [34], Thai patients [32], and also, to a lesser extent (55% of cases), in patients of European origin [36].


Gene_expression (/) of SJS associated with staphylococcus infection and bullous skin disease
15) Confidence 0.35 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.00 Pain Relevance 0.40
This is in agreement with our earlier study showing more intense staining of this HSPG in synovial endothelial cells of longstanding RA compared to normal.14 Cells within the sublining connective tissue were positive for syndecan-3.
Gene_expression (staining) of HSPG in endothelial cells associated with rheumatoid arthritis
16) Confidence 0.31 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 1.00 Pain Relevance 0.39
Both are rare, with TEN and SJS affecting approximately 1or 2/1,000,000 annually, and are considered medical emergencies as they are potentially fatal.
Gene_expression (affecting) of SJS associated with staphylococcus infection, emergencies and bullous skin disease
17) Confidence 0.30 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC3018455 Disease Relevance 1.38 Pain Relevance 0
Pathomechanism of SJS/TEN
Gene_expression (/) of SJS associated with staphylococcus infection and bullous skin disease
18) Confidence 0.30 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.27 Pain Relevance 0.36
Pathomechanism of SJS/TEN
Gene_expression (Pathomechanism) of SJS associated with staphylococcus infection and bullous skin disease
19) Confidence 0.30 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.27 Pain Relevance 0.36
Mockenhaupt et al. were able to show that almost all cases of SJS/TEN developed within 63 days of starting use of antiepileptic drugs, and that the risk of developing SJS/TEN per 10 000 new users was significantly increased for carbamazepine (1.4 cases per 10 000 users), lamotrigine (2.5), phenobarbital (8.1) and phenytoine (8.3).
Gene_expression (developing) of SJS associated with staphylococcus infection, lamotrigine, bullous skin disease, antiepileptic drug and carbamazepine
20) Confidence 0.30 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.18 Pain Relevance 0.40

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