INT76863

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 6.56
Pain Relevance 13.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
epidermis 10
neuronal 2
nerve 2
mesothelial cells 2
MCF-7 2
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 357 100.00 Very High Very High Very High
opiate 49 100.00 Very High Very High Very High
mu opioid receptor 39 100.00 Very High Very High Very High
Opioid receptor 1 6 100.00 Very High Very High Very High
Morphine 133 99.98 Very High Very High Very High
antagonist 87 99.96 Very High Very High Very High
c fibre 5 99.92 Very High Very High Very High
MU agonist 5 99.84 Very High Very High Very High
agonist 52 99.68 Very High Very High Very High
Hypoesthesia 2 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 4 100.00 Very High Very High Very High
Nervous System Injury 5 99.82 Very High Very High Very High
Hypesthesia 2 99.60 Very High Very High Very High
Psoriasis 15 99.56 Very High Very High Very High
Infection 12 99.54 Very High Very High Very High
Eczema 10 99.34 Very High Very High Very High
Immunodeficiency 6 98.48 Very High Very High Very High
Adhesions 8 96.86 Very High Very High Very High
Syndrome 2 94.60 High High
Anaplastic Astrocytoma 2 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of our study indicate that, in MCF-7 cells, MOR gene expression is downregulated by opioid agonists and upregulated by opioid antagonists.
Negative_regulation (downregulated) of Gene_expression (expression) of MOR gene in MCF-7 associated with mu agonist, antagonist and opioid
1) Confidence 0.57 Published 2008 Journal Biochem. Cell Biol. Section Abstract Doc Link 18523482 Disease Relevance 0.15 Pain Relevance 0.99
The same pattern was observed in psoriatic lesional skin, i.e., mu-opiate receptor expression was significantly downregulated and cytokeratin 16 expression upregulated.
Negative_regulation (downregulated) of Gene_expression (expression) of mu-opiate receptor in skin associated with psoriasis and opiate
2) Confidence 0.53 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 10692113 Disease Relevance 0.36 Pain Relevance 0.72
Firstly, we demonstrate that beta-endorphin concentrations between 16 and 1000 nM significantly downregulate mu-opiate receptor expression in epidermis of cultured human skin after 48 h.
Negative_regulation (downregulate) of Gene_expression (expression) of mu-opiate receptor in epidermis associated with opiate
3) Confidence 0.53 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 10692113 Disease Relevance 0.41 Pain Relevance 0.78
Lastly, evaluation of the mu opiate receptor expression was found to be diminished in the diabetics by 59.1 %.
Negative_regulation (diminished) of Gene_expression (expression) of opiate receptor
4) Confidence 0.50 Published 2002 Journal Acta Pharmacol. Sin. Section Body Doc Link 11866867 Disease Relevance 0 Pain Relevance 0
Using primers, a labeled Taq-Man probe derived from the human neuronal mu1 opiate receptor, and real-time RT-PCR to measure the expression of mu transcripts from Mytilus pedal ganglia, we observe, in animals placed in cold water from room temperature, an enhanced morphine and morphine 6 glucuronide level in addition to a decrease in mu opiate receptor gene expression.
Negative_regulation (decrease) of Gene_expression (expression) of opiate receptor in ganglia associated with opioid receptor 1, opiate and morphine
5) Confidence 0.50 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11869805 Disease Relevance 0.07 Pain Relevance 1.14
After 48 h incubation with Naloxone or beta-endorphin the expression of the mu-opiate receptor in epidermis was significantly downregulated compared with the control.
Negative_regulation (downregulated) of Gene_expression (expression) of opiate receptor in epidermis associated with narcan and opiate
6) Confidence 0.47 Published 1998 Journal J. Invest. Dermatol. Section Abstract Doc Link 9699733 Disease Relevance 0 Pain Relevance 0.64
In this study, it was demonstrated that SIV (SIVmac239) infection may result in gradual reduction of the MOR gene expression and Sp1 during a period of 48 h postinfection by analysis of quantitative real-time RT-PCR and Western blotting.
Negative_regulation (reduction) of Gene_expression (expression) of MOR gene associated with mu opioid receptor and infection
7) Confidence 0.44 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.71 Pain Relevance 0.36
The mechanism involved in the repression of the mu opioid receptor gene expression in CEM x174 cells infected by simian immunodeficiency virus.
Negative_regulation (repression) of Gene_expression (expression) of mu opioid receptor associated with repression, mu opioid receptor and immunodeficiency
8) Confidence 0.44 Published 2009 Journal J. Leukoc. Biol. Section Title Doc Link 19164126 Disease Relevance 0.67 Pain Relevance 0.39
As the highest relative expression levels are in transformed neuronal cell lines, MOR1K expression is likely to be suppressed in native cellular conditions.
Negative_regulation (suppressed) of Gene_expression (expression) of MOR1K in neuronal
9) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0.49 Pain Relevance 0.45
These results indicate that re-initiation in MOR gene expression could play an important role in OPRM1 regulation.
Negative_regulation (initiation) of Gene_expression (expression) of MOR gene associated with mu opioid receptor
10) Confidence 0.43 Published 2010 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19438807 Disease Relevance 0 Pain Relevance 0.40
beta-endorphin stimulates cytokeratin 16 expression and downregulates mu-opiate receptor expression in human epidermis.
Negative_regulation (downregulates) of Gene_expression (expression) of mu-opiate receptor in epidermis associated with opiate
11) Confidence 0.39 Published 2000 Journal J. Invest. Dermatol. Section Title Doc Link 10692113 Disease Relevance 0.33 Pain Relevance 0.68
In contrast, MOR expression was suppressed by RAR agonist and by RXR antagonist.
Negative_regulation (suppressed) of Gene_expression (expression) of MOR associated with antagonist, agonist and mu opioid receptor
12) Confidence 0.38 Published 2005 Journal J. Neurovirol. Section Abstract Doc Link 16036794 Disease Relevance 0.31 Pain Relevance 0.91
MOR1K expression and binding pattern
Negative_regulation (pattern) of Gene_expression (expression) of MOR1K
13) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0.33 Pain Relevance 0.65
This study aimed to investigate whether human mesothelial cells express MOR-1; if so, such could constitute a site of action for morphine in adhesion prevention. 2 Cells from Met-5A, a human mesothelial cell line were seeded and prepared for immunocytochemistry and Western blotting. 3 Immunocytochemistry showed MOR-1 expression in mesothelial cells, predominantly in the nuclei.
Negative_regulation (showed) of Gene_expression (expression) of MOR-1 in mesothelial cells associated with adhesions and morphine
14) Confidence 0.37 Published 2009 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 19740087 Disease Relevance 0.56 Pain Relevance 0.48
A RT-PCR was then performed on the endothelium to measure mu opiate receptor expression.
Negative_regulation (measure) of Gene_expression (expression) of opiate receptor in endothelium
15) Confidence 0.36 Published 2002 Journal Acta Pharmacol. Sin. Section Body Doc Link 11866867 Disease Relevance 0 Pain Relevance 0
In contrast, morphine decreases mu opioid receptor expression by 90% in a dose dependent fashion.
Negative_regulation (decreases) of Gene_expression (expression) of mu opioid receptor associated with mu opioid receptor and morphine
16) Confidence 0.36 Published 2001 Journal Int. J. Mol. Med. Section Abstract Doc Link 11445868 Disease Relevance 0.16 Pain Relevance 0.77
CONCLUSION: These observations suggest that compound 3 inhibits MLR through mu-opioid receptor present on cells.


Negative_regulation (inhibits) of Gene_expression (present) of mu-opioid receptor
17) Confidence 0.24 Published 2001 Journal Neuroimmunomodulation Section Body Doc Link 11752886 Disease Relevance 0 Pain Relevance 0
Furthermore, NRSF knockdown significantly blocked nerve injury-induced downregulations of MOP and Na(v)1.8 gene expressions, C-fiber hypoesthesia, and the losses of peripheral morphine analgesia and Na(v)1.8-selective blocker-induced hypoesthesia.
Negative_regulation (downregulations) of Gene_expression (expressions) of MOP in nerve associated with c fibre, nervous system injury, hypoesthesia, opioid receptor, analgesia and morphine
18) Confidence 0.17 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20357131 Disease Relevance 0.92 Pain Relevance 1.31
While the MOR selective antagonist ?
Negative_regulation (While) of Gene_expression (selective) of MOR associated with antagonist and opioid receptor
19) Confidence 0.15 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0.08 Pain Relevance 1.29
Similarly to DAMGO, H2S induces a loss of cell surface expression of MOR as monitored by confocal microscopy and cell membrane fractioning technique.
Negative_regulation (loss) of Gene_expression (expression) of MOR associated with opioid receptor
20) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.63

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