INT76864

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.62
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sds) lyase activity (Sds) cellular amino acid metabolic process (Sds)
cytoplasm (Sds)
Anatomy Link Frequency
plasma 2
liver 2
Sds (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 14 100.00 Very High Very High Very High
Bile 2 79.00 Quite High
Disease Link Frequency Relevance Heat
Nephrotoxicity 1 93.88 High High
Toxicity 6 87.12 High High
Injury 1 78.44 Quite High
Hepatotoxicity 1 65.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Either simultaneous or 2 h delayed treatment with 5beta-S significantly decreased the APAP-induced SDH increase while only the simultaneous pretreatment prevented the BUN elevation. 5beta-S alone did not increase liver glutathione content.
Negative_regulation (decreased) of Positive_regulation (increase) of SDH in liver associated with paracetamol
1) Confidence 0.43 Published 2004 Journal Toxicology Section Abstract Doc Link 15363587 Disease Relevance 0.24 Pain Relevance 1.01
CFB pretreatment also diminished elevation in plasma SDH activity produced by CHCl3 in CD-1 mice, while BUN was significantly elevated in both groups, indicating that CFB did not protect against CHCl3-induced nephrotoxicity.
Negative_regulation (diminished) of Positive_regulation (elevation) of SDH in plasma associated with nephrotoxicity
2) Confidence 0.39 Published 1998 Journal Toxicology Section Abstract Doc Link 9699788 Disease Relevance 0.38 Pain Relevance 0.20

General Comments

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