INT76875

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Context Info
Confidence 0.58
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 3.36
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adm) extracellular region (Adm) response to stress (Adm)
cytoplasm (Adm)
Anatomy Link Frequency
Plasma 5
connective tissue 2
neurons 1
brain 1
DRG 1
Adm (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 5 99.84 Very High Very High Very High
Inflammation 14 98.80 Very High Very High Very High
IPN 2 98.00 Very High Very High Very High
ischemia 3 97.80 Very High Very High Very High
spinal inflammation 8 96.56 Very High Very High Very High
Calcitonin gene-related peptide 4 96.56 Very High Very High Very High
anesthesia 12 95.36 Very High Very High Very High
antagonist 3 93.40 High High
gABA 1 92.48 High High
tetrodotoxin 6 92.24 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 5 99.84 Very High Very High Very High
Disease 18 99.68 Very High Very High Very High
INFLAMMATION 12 98.80 Very High Very High Very High
Inflammatory Pain 2 98.00 Very High Very High Very High
Cv Unclassified Under Development 3 97.80 Very High Very High Very High
Natriuresis 10 96.96 Very High Very High Very High
Low Back Pain 8 96.56 Very High Very High Very High
Injury 2 94.12 High High
Coronary Heart Disease 4 90.64 High High
Familial Mediterranean Fever 8 87.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma adrenomedullin (AM) concentrations increase during and after cardiopulmonary bypass (CPB).
Positive_regulation (increase) of AM in Plasma
1) Confidence 0.58 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12933380 Disease Relevance 0 Pain Relevance 0
The hazards for the time to the first serious complication depending on the initial ProADM level or the time-updated ProADM level, were increased by 2.23 (95% CI 1.91 to 2.61) and 2.44 (95% CI 2.08 to 2.85) per two-fold increase in ProADM.
Positive_regulation (increase) of ProADM
2) Confidence 0.47 Published 2010 Journal Crit Care Section Body Doc Link PMC2911752 Disease Relevance 0 Pain Relevance 0
Plasma adrenomedullin (AM) concentrations increase during and after cardiopulmonary bypass (CPB).
Positive_regulation (increase) of adrenomedullin in Plasma
3) Confidence 0.42 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12933380 Disease Relevance 0 Pain Relevance 0
Increased tissue levels of AM appear to be a potential defence against ESWL induced ischemia.
Positive_regulation (Increased) of AM associated with ischemia
4) Confidence 0.41 Published 2003 Journal Urol. Res. Section Abstract Doc Link 12830337 Disease Relevance 0.34 Pain Relevance 0.17
Percent rise in AM during CPB relative to control period correlated with that of plasma brain natriuretic peptide (r = 0.57, P < 0.01).
Positive_regulation (rise) of AM in brain associated with natriuresis
5) Confidence 0.40 Published 2001 Journal Acta Med. Okayama Section Abstract Doc Link 11512567 Disease Relevance 0.24 Pain Relevance 0.08
Plasma AM levels increased significantly 10 min before the end of CPB and decreased 24 h after operation.
Positive_regulation (increased) of AM in Plasma
6) Confidence 0.40 Published 2001 Journal Acta Med. Okayama Section Abstract Doc Link 11512567 Disease Relevance 0.22 Pain Relevance 0.10
We investigated the role of the hepatosplanchnic and cerebral circulations in the increase of plasma AM and investigated whether tissue hypoxygenation is a cause of the AM increase seen during CPB.
Spec (whether) Positive_regulation (increase) of AM in plasma
7) Confidence 0.39 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12933380 Disease Relevance 0 Pain Relevance 0.07
We investigated the role of the hepatosplanchnic and cerebral circulations in the increase of plasma AM and investigated whether tissue hypoxygenation is a cause of the AM increase seen during CPB.
Spec (investigated) Positive_regulation (increase) of AM in plasma
8) Confidence 0.39 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12933380 Disease Relevance 0 Pain Relevance 0.06
Plasma AM levels were elevated in connective tissue diseases and vasculitic disorders.
Positive_regulation (elevated) of AM in connective tissue associated with disease
9) Confidence 0.23 Published 2008 Journal Joint Bone Spine Section Abstract Doc Link 18394945 Disease Relevance 1.05 Pain Relevance 0.47
Previous reports of elevated levels of AM in connective tissue disorders and vasculitic diseases are probably disease specific, and AM does not seem to be a common component of inflammatory rheumatic disorders.


Positive_regulation (elevated) of AM in connective tissue
10) Confidence 0.23 Published 2008 Journal Joint Bone Spine Section Body Doc Link 18394945 Disease Relevance 0.11 Pain Relevance 0
In addition, hypobaria modulates alternative splicing of the AM gene resulting in a higher production of AM.
Positive_regulation (resulting) of AM
11) Confidence 0.07 Published 2008 Journal Brain Pathol. Section Abstract Doc Link 18371176 Disease Relevance 0.44 Pain Relevance 0.17
In contrast, parvocellular (type II) neurons depolarized following AM receptor activation.
Positive_regulation (activation) of AM in neurons
12) Confidence 0.01 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12388465 Disease Relevance 0.06 Pain Relevance 0.39
Our results indicate that AM increases Isc (short-circuit current) for Cl- secretion (100 nM:170.0 +/- 41.2%, 1 microM:193.8 +/- 45.5%, 100% Isc:28.2 +/- 3.1 microA/cm2) with an initial small decrease of Isc, inhibiting Na+ absorption.
Positive_regulation (increases) of AM
13) Confidence 0.01 Published 1998 Journal Peptides Section Abstract Doc Link 9700753 Disease Relevance 0 Pain Relevance 0.23
Taken together, our results suggest that the upregulation of AM in DRG neurons contributes to the development of inflammatory pain, and this effect is mediated, at least in part, by enhancing the expression and release of CGRP.
Positive_regulation (upregulation) of AM in DRG associated with dorsal root ganglion, ipn and calcitonin gene-related peptide
14) Confidence 0.01 Published 2009 Journal Pain Section Abstract Doc Link 19683388 Disease Relevance 0.89 Pain Relevance 0.98

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