INT76884

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 22
Total Number 26
Disease Relevance 12.84
Pain Relevance 4.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cp) extracellular space (Cp) oxidoreductase activity (Cp)
extracellular region (Cp)
Anatomy Link Frequency
neuronal 1
ventricular zone 1
brain blood vessels 1
astrocyte 1
cortex 1
Cp (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 95 100.00 Very High Very High Very High
Inflammation 324 98.34 Very High Very High Very High
chemokine 31 97.82 Very High Very High Very High
fibrosis 22 95.44 Very High Very High Very High
Demyelination 32 94.84 High High
GABAergic 34 91.72 High High
gABA 20 87.04 High High
cytokine 34 79.28 Quite High
Central nervous system 121 72.56 Quite High
Bile 16 45.28 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 130 100.00 Very High Very High Very High
Infection 90 99.42 Very High Very High Very High
Disease 114 99.10 Very High Very High Very High
Neurodegenerative Disease 49 98.50 Very High Very High Very High
INFLAMMATION 350 98.34 Very High Very High Very High
Demyelinating Disease 49 97.88 Very High Very High Very High
Meningitis 40 97.84 Very High Very High Very High
Targeted Disruption 8 96.68 Very High Very High Very High
Primary Sclerosing Cholangitis 60 96.24 Very High Very High Very High
Fibrosis 20 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accentuated iron accumulation in Cp-/-animals seems to correlate with neurodegeneration in this genotype, at least as evaluated by the fluorescent marker Fluoro Jade B (FJB, Fig. 6D).
Positive_regulation (accumulation) of Cp
1) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.26 Pain Relevance 0.19
We then postulated that induction of Cp might be a potent neuroprotective mechanism during acute inflammation.
Positive_regulation (induction) of Cp associated with inflammation
2) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.33 Pain Relevance 0.05
Implementing trainees reported positive effects of CP for themselves, patients, and physicians.
Positive_regulation (effects) of CP
3) Confidence 0.58 Published 2008 Journal Implement Sci Section Body Doc Link PMC2270865 Disease Relevance 0 Pain Relevance 0
Cp is not required for LPS mediated iron (III) deposition, but this protein seems to play a role avoiding precipitated iron unbalance.
Neg (not) Positive_regulation (required) of Cp
4) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.86 Pain Relevance 0.18
S. pneumoniae infection was used to test a possible role of Cp in this context.
Spec (possible) Positive_regulation (role) of Cp associated with infection
5) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.85 Pain Relevance 0.15
Nevertheless, Cp was strongly induced in brain blood vessels of infected Cp+/+ mice (Fig. 7B).
Positive_regulation (induced) of Cp in brain blood vessels
6) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.78 Pain Relevance 0.13
Because iron unbalance is implicated in demyelinating and neurodegenerative diseases [33], [34] and aceruloplasminemia leads to brain, liver and pancreas iron accumulation with concomitant neuronal damages [35], [36], Cp is a putative candidate to mediate neuroprotection during inflammation.
Positive_regulation (accumulation) of Cp in neuronal associated with inflammation, neurodegenerative disease and demyelinating disease
7) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.91 Pain Relevance 0.16
Iron accumulation in human disease and murine models led to the inference that Cp is important to release iron from the cellular pool, especially mediated by a membrane glycosylphosphatidylinositol-form of this ferroxidase [39].
Positive_regulation (important) of Cp associated with disease
8) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.89 Pain Relevance 0.15
Microglial and endothelial induction of Cp is a natural neuroprotective mechanism during inflammation, because Cp-deficient mice exhibited increased iron accumulation and demyelination when exposed to LPS and neurovascular reactivity to pneumococcal meningitis.
Positive_regulation (induction) of Cp associated with demyelination, inflammation and pneumococcal meningitis
9) Confidence 0.46 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1819560 Disease Relevance 0.69 Pain Relevance 0.17
According to these trainees, the main barriers to implementation included the scarcity of program resources and the need to prioritize services more basic than CP, in some cases because CP was realistically suited to the context in which they operated (e.g., underserved patients without access to care, much less high degrees of involvement in consultations.)
Positive_regulation (suited) of CP
10) Confidence 0.42 Published 2008 Journal Implement Sci Section Body Doc Link PMC2270865 Disease Relevance 0 Pain Relevance 0
Two major themes emerged in the trainee interviews related to delivering the intervention to patients: the sense of trainee satisfaction due to the perceived value of the CP intervention to patients; and the adaptations made by trainees as they implemented CP.
Positive_regulation (implemented) of CP
11) Confidence 0.42 Published 2008 Journal Implement Sci Section Body Doc Link PMC2270865 Disease Relevance 0.08 Pain Relevance 0
A primary finding of our interviews was that 14 of 18 respondents did implement CP after only a single day of training, and with no other technical assistance from CP developers and trainers.
Positive_regulation (implement) of CP
12) Confidence 0.42 Published 2008 Journal Implement Sci Section Body Doc Link PMC2270865 Disease Relevance 0 Pain Relevance 0
increased CP significantly in the astrocyte and mixed glial cultures.


Positive_regulation (increased) of CP in astrocyte
13) Confidence 0.16 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.47 Pain Relevance 0
Experimental CP was induced by repeated administration of cerulein and lipopolysaccharide for 6 weeks.
Positive_regulation (induced) of CP associated with chronic pancreatitis
14) Confidence 0.11 Published 2006 Journal Antioxid. Redox Signal. Section Abstract Doc Link 16987036 Disease Relevance 1.11 Pain Relevance 0.76
Median CXCL13-mRNA levels in AIPC were also significantly higher than in the other groups, with a 21-fold increase compared to CP (p?
Positive_regulation (increase) of CP associated with chronic pancreatitis
15) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.16 Pain Relevance 0.53
Median CXCR5-mRNA levels in AIPC showed a 4.1-fold increase in comparison with CP (p?
Positive_regulation (increase) of CP associated with chronic pancreatitis
16) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.08 Pain Relevance 0.49
Pancreatic leakages were detected in 3 (18.8% [3/16]) patients who underwent PHRSD and in 3 patients (21.4% [3/14]) who underwent CP.
Positive_regulation (underwent) of CP
17) Confidence 0.10 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800014 Disease Relevance 0.92 Pain Relevance 0
It has to be underlined, however, that the OD shift induced by MD in adult animals with reduced intracortical inhibition (Harauzov et al., 2010) is smaller than that induced during the CP.
Positive_regulation (induced) of CP
18) Confidence 0.07 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2854574 Disease Relevance 0 Pain Relevance 0.03
Indeed, Fagiolini and Hensch (2000) have shown that precocious enhancement of IGI by the early administration of diazepam to the visual cortex accelerates the opening of the CP (Figure 1).
Positive_regulation (accelerates) of CP in cortex
19) Confidence 0.07 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2854574 Disease Relevance 0.29 Pain Relevance 0.13
AIMS: Our primary aim was to assess the correlation and concordance of combined EUS and secretin ePFT bicarbonate results in suspected minimal change CP.
Positive_regulation (results) of CP
20) Confidence 0.05 Published 2010 Journal Dig. Dis. Sci. Section Body Doc Link 20101462 Disease Relevance 0.09 Pain Relevance 0

General Comments

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