INT76890

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Context Info
Confidence 0.65
First Reported 1998
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 42
Total Number 46
Disease Relevance 13.91
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FGFR2) Golgi apparatus (FGFR2) cytoplasmic membrane-bounded vesicle (FGFR2)
plasma membrane (FGFR2) nucleus (FGFR2) cell-cell signaling (FGFR2)
Anatomy Link Frequency
cartilage 5
chondrocytes 4
keratinocyte 2
plasma 1
fibroblast 1
FGFR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Snapping jaw 23 95.88 Very High Very High Very High
Chronic pancreatitis 6 95.56 Very High Very High Very High
dexamethasone 1 93.32 High High
metalloproteinase 11 92.56 High High
Pain 18 84.28 Quite High
alcohol 1 78.12 Quite High
COX-2 inhibitor 6 76.08 Quite High
lidocaine 1 68.64 Quite High
Inflammation 94 41.72 Quite Low
Crohn's disease 10 31.56 Quite Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 8 100.00 Very High Very High Very High
Injury 156 99.96 Very High Very High Very High
Wound Healing 369 99.68 Very High Very High Very High
Breast Cancer 155 99.24 Very High Very High Very High
Adamantinoma 93 99.24 Very High Very High Very High
Eosinophilic Esophagitis 212 99.08 Very High Very High Very High
Hypoxia 15 97.88 Very High Very High Very High
Gastroesophageal Reflux Disease 72 97.16 Very High Very High Very High
Metastasis 73 96.44 Very High Very High Very High
Temporomandibular Joint Syndrome 23 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The recombined allele was identified using primers FGFR2F5 and FGFR2rec (5?
Gene_expression (using) of FGFR2
1) Confidence 0.65 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.14 Pain Relevance 0
The recombined allele was identified using primers FGFR2F5 and FGFR2rec (5?
Gene_expression (using) of FGFR2
2) Confidence 0.65 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.14 Pain Relevance 0
Genotyping PCR for the Fgfr2 floxed allele was performed using primers FGFR2F5 (5?
Gene_expression (using) of FGFR2
3) Confidence 0.65 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.13 Pain Relevance 0
Using antibodies for FGFR1 (flg) and FGFR2 (bek), we found expression of these proteins in cell membranes throughout the intact neural retina (Figures 5A,D).
Gene_expression (expression) of bek in neural retina
4) Confidence 0.58 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684558 Disease Relevance 0 Pain Relevance 0
Other variables including estrogen receptor (ER), progesterone receptor (PR), and epidermal growth factor receptor-2 (HER2) expression vary widely among breast cancer patients and thus are routinely assessed as a component of standard care for determining the most effective treatment.
Gene_expression (expression) of factor receptor-2 associated with breast cancer
5) Confidence 0.50 Published 2010 Journal Current Genomics Section Body Doc Link PMC2878980 Disease Relevance 1.09 Pain Relevance 0.04
Here we evaluate the differentiation capacity of hES cells into hepatocytes. hES cells were subjected to suspension culture for 5 days, and then cultured onto poly-amino-urethane (PAU)-coated, nonwoven polytetrafluoroethylene (PTFE) fabric in the presence of fibroblast growth factor-2 (bFGF) (100 ng/ml) for 3 days, then with deleted variant of hepatocyte growth factor (dHGF) (100 ng/ml) and 1% dimethyl sulfoxide (DMSO) for 8 days, and finally with dexamethasone (10(-7) M) for 3 days.
Gene_expression (presence) of fibroblast growth factor-2 in hepatocyte associated with dexamethasone
6) Confidence 0.42 Published 2006 Journal Cell Transplant Section Abstract Doc Link 16898227 Disease Relevance 0 Pain Relevance 0.12
Several FGFs, including FGF-1, -2, -3, -4, -5, -6, and -7, and several FGFR variants, among them the 2 immunoglobulin-like form and the IIIc splice variant of FGFR-1 and the keratinocyte growth factor receptor, a splice variant of FGFR-2, are expressed in human pancreatic cancer cell lines and are overexpressed in human pancreatic cancers or in the pancreas of chronic pancreatitis and, therefore, may play important roles in the pathobiology of these pancreatic diseases.
Gene_expression (expressed) of FGFR-2 in keratinocyte associated with pancreatitis, pancreatic cancer and chronic pancreatitis
7) Confidence 0.40 Published 1998 Journal Pancreas Section Abstract Doc Link 9700949 Disease Relevance 0.61 Pain Relevance 0.24
The regulated genes include DUSP1, DUSP2, DUSP8, MAP3K8, MAP4K4, FGF13, FGFR2 and FOS.
Gene_expression (include) of FGFR2
8) Confidence 0.40 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.50 Pain Relevance 0
To analyze KGF and KGFR expression, the cells were further incubated in collagen-coated chamber slides (Lab-Tek, Nalge Nunc International, Naperville, IL, USA) for 2 more days.
Spec (analyze) Gene_expression (expression) of KGFR
9) Confidence 0.38 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.13 Pain Relevance 0
Cell proliferation and expression of KGF and KGFR in tracheal cartilage after surgery
Gene_expression (expression) of KGFR in cartilage
10) Confidence 0.38 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.18 Pain Relevance 0
For this purpose, we examined immunohistochemically the expression of KGF and KGFR in relation to proliferative activity in a rat model of regenerating tracheal cartilage.
Spec (examined) Gene_expression (expression) of KGFR in cartilage
11) Confidence 0.38 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.16 Pain Relevance 0
FGFR2-IIIb/KGFR is expressed in various epithelia and plays important roles in epithelial homeostasis and regeneration.
Gene_expression (expressed) of KGFR
12) Confidence 0.38 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.08 Pain Relevance 0
Finch et al. [8] reported that KGF and KGFR are expressed on the cartilage of limbs, ribs, larynx, and trachea from embryonic stage, it is possible that the use of KGF with these growth factors may have enhancing, competitive, or other specific effects on the hyaline cartilage.
Gene_expression (expressed) of KGFR in trachea associated with osteoarthritis
13) Confidence 0.38 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.26 Pain Relevance 0.10
Expression of KGF and KGFR in primary cultured chondrocytes
Gene_expression (Expression) of KGFR in chondrocytes
14) Confidence 0.38 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.08 Pain Relevance 0
EoE subjects had statistically significant increased FGFR2 expression compared to HC (14×, p < 0.05) (Figure 1a).
Gene_expression (expression) of FGFR2 associated with eosinophilic esophagitis
15) Confidence 0.35 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.95 Pain Relevance 0
Recently, Mulder et al. found increased FGF-9 and FGF-Receptor expression levels in tissue from EoE subjects (n = 7) compared to HC (n = 7) and GERD (n = 7).
Gene_expression (expression) of FGF-Receptor associated with gastroesophageal reflux disease and eosinophilic esophagitis
16) Confidence 0.35 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.99 Pain Relevance 0
In the present study, KGFR was expressed in the perichondrium during wound healing but not under normal physiological condition.
Neg (not) Gene_expression (expressed) of KGFR in perichondrium associated with wound healing
17) Confidence 0.33 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.31 Pain Relevance 0
The perichondrial cells were almost negative for KGFR.
Neg (negative) Gene_expression (negative) of KGFR
18) Confidence 0.33 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.14 Pain Relevance 0
On the other hand, KGFR was detected only in the plasma membrane of chondrocytes in the tracheal (Fig. 3B) and nasal septum (data not shown) cartilage.
Gene_expression (detected) of KGFR in plasma
19) Confidence 0.30 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.11 Pain Relevance 0
The other sections were used for immunohistochemical analysis of KGF, KGFR, and PCNA expression in the wound healing area.


Gene_expression (expression) of KGFR associated with wound healing
20) Confidence 0.30 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.33 Pain Relevance 0

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