INT7691

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Context Info
Confidence 0.43
First Reported 1992
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 0.41
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Rnase1)
Rnase1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 66 71.40 Quite High
Glutamate receptor 1 62.72 Quite High
lidocaine 2 58.60 Quite High
algil 2 58.16 Quite High
anesthesia 2 55.08 Quite High
corticosteroid 35 50.00 Quite Low
cva 2 47.92 Quite Low
monoamine 4 28.56 Quite Low
Enkephalin 3 25.00 Low Low
dexamethasone 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 38 85.52 High High
INFLAMMATION 64 71.40 Quite High
Exencephaly /

Neural Tube Defects

2 69.84 Quite High
Coronary Heart Disease 1 69.00 Quite High
Dislocations 1 53.92 Quite High
Diabetes Mellitus 51 50.00 Quite Low
Apoptosis 30 50.00 Quite Low
Lung Injury 11 50.00 Quite Low
Malignant Neoplastic Disease 4 49.96 Quite Low
Hemorrhage 2 47.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RNase resistance is afforded by the inclusion of RNase inhibitors during steps in which mRNA is vulnerable to RNase digestion, alleviating the need to maintain RNase-free conditions during experiments.
Negative_regulation (inhibitors) of RNase
1) Confidence 0.43 Published 1996 Journal J. Neurosci. Methods Section Abstract Doc Link 8815311 Disease Relevance 0 Pain Relevance 0.03
We describe here a protocol developed to detect specific mRNAs by in situ hybridization using tissue sections that were not treated to inactivate RNase and were stored in cryoprotectant solution for several years.
Negative_regulation (inactivate) of RNase
2) Confidence 0.28 Published 1992 Journal Brain Res. Section Abstract Doc Link 1354996 Disease Relevance 0 Pain Relevance 0
To prevent possible RNase contamination from mounting the tissue sections onto gelatin coated slides, the in situ hybridization was performed in sterile culture dishes.
Spec (possible) Negative_regulation (prevent) of RNase
3) Confidence 0.28 Published 1992 Journal Brain Res. Section Abstract Doc Link 1354996 Disease Relevance 0 Pain Relevance 0
l of an RNase inhibitor (RNA Guard; Amersham Pharmacia, Uppsala, Sweden) was added to each sample.


Negative_regulation (inhibitor) of RNase
4) Confidence 0.13 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.12 Pain Relevance 0.06
U/uL RNase inhibitor, and 50?
Negative_regulation (inhibitor) of RNase
5) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.22 Pain Relevance 0.07
Deprenyl was somewhat more effective in inhibition of RNase activity of GAPDH than isatin, and during their combined addition the effect of RNase inhibition was somewhat less pronounced than in the case of independent action of deprenyl (Medvedev et al 2006).
Negative_regulation (inhibition) of RNase
6) Confidence 0.05 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721300 Disease Relevance 0 Pain Relevance 0.12
Deprenyl was somewhat more effective in inhibition of RNase activity of GAPDH than isatin, and during their combined addition the effect of RNase inhibition was somewhat less pronounced than in the case of independent action of deprenyl (Medvedev et al 2006).
Negative_regulation (inhibition) of RNase
7) Confidence 0.05 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721300 Disease Relevance 0 Pain Relevance 0.11
RNase was inactivated, and the protected RNA was precipitated using RNAse inactivation buffer (Ambion, Austin, TX).
Negative_regulation (inactivated) of RNase
8) Confidence 0.02 Published 2009 Journal Respir Res Section Body Doc Link PMC2802354 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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