INT7692

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1981
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 71
Total Number 73
Disease Relevance 20.34
Pain Relevance 32.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PENK) extracellular region (PENK)
Anatomy Link Frequency
striatum 4
PVN 4
caudate-putamen 2
brain 2
hippocampus 2
PENK (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 335 100.00 Very High Very High Very High
Nerve growth factor 8 100.00 Very High Very High Very High
Spinal cord 9 99.98 Very High Very High Very High
cytokine 5 99.98 Very High Very High Very High
substance P 27 99.92 Very High Very High Very High
agonist 12 99.92 Very High Very High Very High
dexamethasone 18 99.72 Very High Very High Very High
Hippocampus 11 99.68 Very High Very High Very High
Dynorphin 22 99.64 Very High Very High Very High
Acupuncture 63 99.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 78 100.00 Very High Very High Very High
Stress 59 100.00 Very High Very High Very High
Parkinson's Disease 49 99.76 Very High Very High Very High
Epilepsy 12 99.74 Very High Very High Very High
Psoriasis 11 99.28 Very High Very High Very High
Cognitive Disorder 14 99.24 Very High Very High Very High
Cold Sores 2 99.24 Very High Very High Very High
INFLAMMATION 8 99.16 Very High Very High Very High
Herpes Simplex Virus 2 99.14 Very High Very High Very High
Convulsion 1 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential effects were induced by agonists of the group II mGluRs, viz. (2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine administered intraventricularly (3 times at 0.1-0.2 microg/4 microl, 3 h apart) increased both the normal and haloperidol-increased proenkephalin mRNA level, whereas (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate injected intrastriatally (3 times at 15 microg/0.5 microl, 3 h apart) was ineffective.
Positive_regulation (increased) of proenkephalin associated with agonist
1) Confidence 0.70 Published 2003 Journal Neuroscience Section Abstract Doc Link 14622918 Disease Relevance 0.13 Pain Relevance 0.30
The proenkephalin mRNA level measured by in situ hybridization in the striatum was increased by pretreatments with haloperidol (1.5 mg/kg s.c., three times, 3 h apart).
Positive_regulation (increased) of proenkephalin in striatum
2) Confidence 0.70 Published 2003 Journal Neuroscience Section Abstract Doc Link 14622918 Disease Relevance 0.26 Pain Relevance 0.34
Triple (3 h apart), bilateral, intrastriatal administration of selective antagonists of mGluR1: (S)-(+)-alpha-amino-4-carboxy-2-methylbenzeneacetic acid (3 x 5 microg/0.5 microl) or 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate (3 x 2.5 microg/0.5 microl), reversed the haloperidol-induced increases in proenkephalin mRNA levels in the rostral and central regions of the striatum.
Positive_regulation (increases) of proenkephalin in striatum associated with antagonist
3) Confidence 0.70 Published 2003 Journal Neuroscience Section Abstract Doc Link 14622918 Disease Relevance 0.23 Pain Relevance 0.38
Dexamethasone treatment, which increased enkephalin levels, also decreased catecholamine levels.
Positive_regulation (increased) of enkephalin
4) Confidence 0.70 Published 2008 Journal Life Sci. Section Body Doc Link 18706432 Disease Relevance 0.08 Pain Relevance 0
Receptor-mediated induction of the human proenkephalin gene has been mapped to an imperfect palindrome located between -104 and -86, upstream of the transcriptional start site.
Positive_regulation (induction) of proenkephalin gene
5) Confidence 0.69 Published 1994 Journal Biochemistry Section Abstract Doc Link 7918415 Disease Relevance 0 Pain Relevance 0.07
Furthermore the data demonstrates a steroid-sensitive stress mediated increase in proenkephalin A mRNA which provides additional evidence for a role of the endogenous opiates in the hypothalamic neuroendocrine response to stress.
Positive_regulation (increase) of proenkephalin A associated with stress and opiate
6) Confidence 0.67 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2789345 Disease Relevance 0.52 Pain Relevance 0.18
However, the temporal delay between the elevation of the intracellular cAMP content and the increase in nerve growth factor and proenkephalin mRNAs prompted us to investigate whether additional mechanisms associated with the second messenger were operative in the regulation of the expression of these two genes.
Positive_regulation (increase) of proenkephalin in nerve associated with nerve growth factor
7) Confidence 0.67 Published 1989 Journal Pharmacol. Res. Section Abstract Doc Link 2698474 Disease Relevance 0 Pain Relevance 0.29
Inhibition of L-type Ca2+ channels blocks forskolin-mediated induction of proenkephalin.
Positive_regulation (induction) of proenkephalin
8) Confidence 0.67 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12877986 Disease Relevance 0 Pain Relevance 0.08
An analysis of prolactin-secreting microadenomas showed an increase in the proenkephalin A system.
Positive_regulation (increase) of proenkephalin A
9) Confidence 0.67 Published 1999 Journal J. Chromatogr. B Biomed. Sci. Appl. Section Abstract Doc Link 10491985 Disease Relevance 0 Pain Relevance 0.48
Unilateral implants of cholesterol directly over the PVN had no effect on either basal or stress-induced increase of CRF and proenkephalin A message.
Positive_regulation (increase) of proenkephalin A in PVN associated with stress
10) Confidence 0.67 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2789345 Disease Relevance 0.42 Pain Relevance 0.15
The endogenous proenkephalin mRNA was induced in parallel with the transgene as demonstrated by in situ hybridization; the immediate-early gene c-fos was also regulated in parallel with the transgene.
Positive_regulation (induced) of proenkephalin
11) Confidence 0.67 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7996174 Disease Relevance 0.82 Pain Relevance 0.70
Application of N-methyl-D-aspartate on to the dendrites of hippocampal granule cells dramatically decreased prodynorphin messenger RNA levels in the affected cells while increasing proenkephalin messenger RNA levels.
Positive_regulation (increasing) of proenkephalin in hippocampal granule cells
12) Confidence 0.67 Published 1994 Journal Neuroscience Section Abstract Doc Link 7969920 Disease Relevance 0 Pain Relevance 0.14
T helper 2 cytokines induce preproenkephalin mRNA expression and proenkephalin A in human peripheral blood mononuclear cells.
Positive_regulation (induce) of proenkephalin A in blood associated with cytokine
13) Confidence 0.67 Published 1997 Journal J. Neuroimmunol. Section Title Doc Link 9357452 Disease Relevance 0 Pain Relevance 0.65
Treatment of cultured Leydig cells with hCG or a cAMP analog leads to a rapid increase in proenkephalin-mRNA levels.
Positive_regulation (increase) of proenkephalin in Leydig cells
14) Confidence 0.67 Published 1989 Journal Mol. Endocrinol. Section Abstract Doc Link 2560809 Disease Relevance 0 Pain Relevance 0.08
NE or dbcAMP for 1-48 h transiently elevated proenkephalin A mRNA 1.5-4.5 times compared to control.
Positive_regulation (elevated) of proenkephalin A
15) Confidence 0.67 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2542716 Disease Relevance 0.08 Pain Relevance 0.41
These data suggest that noradrenergic pathways are not involved in maintaining basal levels of CRF mRNA and that the noradrenergic input through the VNAB does not mediate the accumulation of CRF and proenkephalin A mRNAs in response to these stressors.
Positive_regulation (accumulation) of proenkephalin A
16) Confidence 0.67 Published 1991 Journal Brain Res. Section Abstract Doc Link 1655164 Disease Relevance 0.48 Pain Relevance 0.16
Unilateral injections of 6-hydroxydopamine (6-OHDA) cause significant bilateral increases in striatal proenkephalin (PEK) mRNA in rat brain.
Positive_regulation (increases) of proenkephalin in brain
17) Confidence 0.67 Published 1991 Journal Brain Res. Bull. Section Abstract Doc Link 1756390 Disease Relevance 0 Pain Relevance 0.11
The increased level of proenkephalin and prodynorphin opioid peptides in brain structures, essential for the appearance of spike-wave discharges, suggests that these opioid systems, but not proopiomelanocortin one, may play a role in absence epilepsy.
Positive_regulation (increased) of proenkephalin in spike associated with absence epilepsy and opioid
18) Confidence 0.67 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630600 Disease Relevance 0.84 Pain Relevance 0.54
Injection of 50 microM NMDA in vivo on to the granule cells of the dentate gyrus results in a highly localized increase in Penk mRNA levels 24 h later, while vehicle has no effect.
Positive_regulation (increase) of Penk in dentate gyrus
19) Confidence 0.67 Published 1994 Journal Neuroreport Section Abstract Doc Link 7948847 Disease Relevance 0 Pain Relevance 0.08
Proenkephalin mRNA increased in the hippocampus during seizure just after an increase in c-fos and c-jun expression was detected.
Positive_regulation (increased) of Proenkephalin in hippocampus associated with convulsion and hippocampus
20) Confidence 0.67 Published 1989 Journal Science Section Abstract Doc Link 2512642 Disease Relevance 0.10 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox