INT76924

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 71
Total Number 74
Disease Relevance 41.21
Pain Relevance 19.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc17a5) cytoplasmic membrane-bounded vesicle (Slc17a5) plasma membrane (Slc17a5)
transmembrane transport (Slc17a5) lysosome (Slc17a5)
Anatomy Link Frequency
liver 12
plasma 5
fat 2
monocyte 2
white blood cell 1
Slc17a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 895 99.82 Very High Very High Very High
Inflammation 272 99.54 Very High Very High Very High
withdrawal 9 99.24 Very High Very High Very High
ischemia 198 98.76 Very High Very High Very High
imagery 12 98.38 Very High Very High Very High
headache 5 95.16 Very High Very High Very High
Potency 417 92.84 High High
aspirin 6 92.72 High High
analgesia 3 92.20 High High
Analgesic 23 91.56 High High
Disease Link Frequency Relevance Heat
Disease 100 100.00 Very High Very High Very High
Urological Neuroanatomy 21 100.00 Very High Very High Very High
Rickettsiaceae Infection 50 99.98 Very High Very High Very High
Jaundice 65 99.92 Very High Very High Very High
INFLAMMATION 280 99.90 Very High Very High Very High
Gastrointestinal Stromal Tumor 42 99.64 Very High Very High Very High
Meningism 12 99.60 Very High Very High Very High
Necrosis 167 99.18 Very High Very High Very High
Hepatotoxicity 466 99.00 Very High Very High Very High
Cv Unclassified Under Development 240 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mild elevation of liver enzymes (AST and ALT elevated >1-fold in 81% and 75%, respectively) was the most frequent laboratory finding.
Positive_regulation (elevation) of AST in liver
1) Confidence 0.70 Published 2007 Journal Eur. J. Clin. Microbiol. Infect. Dis. Section Abstract Doc Link 17554571 Disease Relevance 0.96 Pain Relevance 0.10
Elevation of serum ALT and AST activities, decrease of reduced glutathione levels and histopathological liver changes were observed to the same extents in both APAP-treated groups.
Positive_regulation (Elevation) of AST in liver associated with paracetamol
2) Confidence 0.61 Published 2009 Journal Toxicology Section Abstract Doc Link 19576946 Disease Relevance 0.22 Pain Relevance 0.71
Three hours after TBE or K/X administration, AST activity increased three- to fourfold above that in untreated and saline-injected control animals, and remained high at six hours.
Positive_regulation (increased) of AST
3) Confidence 0.47 Published 2002 Journal Comp. Med. Section Abstract Doc Link 11900415 Disease Relevance 0.22 Pain Relevance 0.30
Mild elevation of liver enzymes (AST and ALT elevated >1-fold in 81% and 75%, respectively) was the most frequent laboratory finding.
Positive_regulation (elevated) of AST in liver
4) Confidence 0.47 Published 2007 Journal Eur. J. Clin. Microbiol. Infect. Dis. Section Abstract Doc Link 17554571 Disease Relevance 0.96 Pain Relevance 0.09
Similarly, sodium sulphate (200 mg/kg) administered alone to PCM-treated mice had no effect on the high mortality rate or the elevation in plasma AST and ALT activities observed in these animals.
Positive_regulation (elevation) of AST in plasma associated with paracetamol
5) Confidence 0.44 Published 1998 Journal Inflammopharmacology Section Abstract Doc Link 17657622 Disease Relevance 0.14 Pain Relevance 0.69
On the other hand, APAP induced increases in plasma AST and ALT levels in the highest dose group only, and the DNA damage in the liver increased at the same dose.
Positive_regulation (increases) of AST in plasma associated with paracetamol
6) Confidence 0.44 Published 2008 Journal J Toxicol Sci Section Abstract Doc Link 19043273 Disease Relevance 0.09 Pain Relevance 0.38
As a result, pretreated with ASE prior to the administration of APAP significantly prevented the increases of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-alpha) levels in serum, and glutathione (GSH) depletion, malondialdehyde (MDA) accumulation in liver tissue.
Positive_regulation (increases) of AST in liver associated with necrosis, paracetamol and cancer
7) Confidence 0.41 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19801828 Disease Relevance 0.53 Pain Relevance 0.57
However, at higher doses of sunitinib in group D, both the AST and ALT levels were significantly increased (Figure 1).
Positive_regulation (increased) of AST
8) Confidence 0.39 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.42 Pain Relevance 0.53
Mice treated with increasing doses of sunitinib showed a gradual elevation of AST serum concentration (range 204.64 - 290.28 U/L) following rising sunitinib doses.
Positive_regulation (elevation) of AST
9) Confidence 0.39 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.07 Pain Relevance 0.38
BUN and serum creatinine, ALT and AST levels which were increased significantly following AA treatment decreased significantly after pretreatment with either vitamin E, melatonin or NAC; however, they were not reduced to control levels.
Positive_regulation (increased) of AST associated with paracetamol
10) Confidence 0.39 Published 2003 Journal J. Pineal Res. Section Abstract Doc Link 12823615 Disease Relevance 0.50 Pain Relevance 0.67
A significant increase in the AST value with respect to control was also observed.
Positive_regulation (increase) of AST
11) Confidence 0.39 Published 2008 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 19230593 Disease Relevance 0 Pain Relevance 0.63
A significant increase in the AST value with respect to control was also observed.
Positive_regulation (increase) of AST
12) Confidence 0.39 Published 2009 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 19462927 Disease Relevance 0 Pain Relevance 0.63
A significant elevation (p<0.001) of the levels of AST and ALT was observed in mice toxicated with APAP.
Positive_regulation (elevation) of AST associated with paracetamol
13) Confidence 0.37 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19109935 Disease Relevance 0.68 Pain Relevance 0.70
However, a significant inhibition (p<0.05) in the elevation of AST and ALT was observed in mice that received UBG and GIBG compared with APAP-treated mice.
Positive_regulation (elevation) of AST associated with paracetamol
14) Confidence 0.37 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19109935 Disease Relevance 0.68 Pain Relevance 0.77
The more frequent use of routine CT and MRI scanning, as well as endoscopy, in the diagnosis of sinus disease has led to an increase in the early diagnosis of ISSD.
Positive_regulation (increase) of ISSD in sinus associated with disease and imagery
15) Confidence 0.36 Published 2002 Journal Ann. Otol. Rhinol. Laryngol. Section Abstract Doc Link 11991583 Disease Relevance 1.52 Pain Relevance 0.21
However, a large increase in AST concentrations were observed at the higher doses of sunitinib coadministered with paracetamol which was statistically significant at 100 mg/kg (p < 0.01) and 140 mg/kg (p < 0.001) doses.
Positive_regulation (increase) of AST associated with paracetamol
16) Confidence 0.34 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.05 Pain Relevance 0.47
The extract had no significant effect on the increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin in CCl(4) treated animals (p > 0.05).
Positive_regulation (increased) of AST
17) Confidence 0.34 Published 2006 Journal Phytother Res Section Abstract Doc Link 16619345 Disease Relevance 0.18 Pain Relevance 0.65
In mice, acetaminophen (500 mg/kg, p.o.) caused fulminant liver damage characterized by centrilobular necrosis with inflammatory cell infiltration, an increase in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, a decrease in hepatic glutathione (GSH) and 50% mortality.
Positive_regulation (increase) of AST in liver associated with necrosis, paracetamol, inflammation and hepatotoxicity
18) Confidence 0.31 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15763370 Disease Relevance 0.55 Pain Relevance 0.55
Pretreatment with alpha- and beta-amyrin (50 and 100 mg/kg, i.p. at 48, 24, and 2 h before acetaminophen) attenuated the acetaminophen-induced acute increase in serum ALT and AST activities, replenished the depleted hepatic GSH, and considerably reduced the histopathological alterations in a manner similar to N-acetylcysteine, a sulfhydryls donor.
Positive_regulation (increase) of AST associated with paracetamol
19) Confidence 0.31 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15763370 Disease Relevance 0.60 Pain Relevance 0.56
The results showed that the extract induced significant effects: an increase in the activities of AST (p< 0.001) and ALT (p< 0.02), an increase in the mean corpuscular haemoglobin concentration (MCHC) (p< 0.01), and the monocyte count (p< 0.01).
Positive_regulation (increase) of AST in monocyte
20) Confidence 0.31 Published 2001 Journal Int J Environ Health Res Section Abstract Doc Link 11260789 Disease Relevance 0.29 Pain Relevance 0.09

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