INT7695

Context Info Confidence 0.30 First Reported 1991 Last Reported 2009 Negated 1 Speculated 0 Reported most in Abstract Documents 13 Total Number 13 Disease Relevance 1.51 Pain Relevance 6.51

oxidoreductase activity (Fdft1) endoplasmic reticulum (Fdft1) transferase activity, transferring alkyl or aryl (other than methyl) groups (Fdft1)

Anatomy Link Frequency striatum 2 pituitary 1 astrocytes 1 nociceptors 1 hippocampus 1 Fdft1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Somatostatin 94 100.00 Calcitonin gene-related peptide 37 99.82 substance P 33 99.64 Neuropeptide 16 99.36 tetrodotoxin 2 99.02 Hippocampus 19 98.68 Clonidine 10 98.56 nociceptor 4 98.02 unmyelinated 1 97.78 antagonist 2 95.92

Disease Link Frequency Relevance Heat Urological Neuroanatomy 9 99.44 Nociception 25 90.16 Neurogenic Inflammation 2 87.76 Pain 24 82.32 Stress 12 56.56 Hyperalgesia 1 46.80 Polycystic Ovary Syndrome 7 5.00 Body Weight 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, a single electrical stimulus increased PE mRNA in ventral striatum and SS mRNA in cingulate cortex and olfactory tubercle.

Positive_regulation (increased) of SS mRNA in striatum associated with somatostatin

1) Confidence 0.30 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684628 Disease Relevance 0.08 Pain Relevance 0.44

In situ hybridization analysis, one day after the last kindling stimulation, showed significant elevations of SS mRNA in CA1, CA2 and dentate gyrus of hippocampus and of PE mRNA in olfactory cortex that were specific to kindling.

Positive_regulation (elevations) of SS mRNA in olfactory cortex associated with somatostatin and hippocampus

2) Confidence 0.23 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684628 Disease Relevance 0.09 Pain Relevance 0.44

Blot analysis of total RNA showed increases in SS mRNA in striatum, frontal cortex and hippocampus of animals receiving only a single stimulation as well as kindled animals--the increase occurred 1-3 days following stimulation and levels were back to basal by 1 week.

Positive_regulation (increases) of SS mRNA in hippocampus associated with somatostatin, urological neuroanatomy and hippocampus

3) Confidence 0.20 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684628 Disease Relevance 0.10 Pain Relevance 0.34

In this study, we have extended this analysis by looking at the time course of changes in SS and PE mRNAs at various times after kindling, in comparison with a single non-convulsive stimulation.

Positive_regulation (changes) of SS associated with somatostatin

4) Confidence 0.20 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684628 Disease Relevance 0.09 Pain Relevance 0.32

Depolarizing stimuli, such as 56 mM K+ concentration for 24 hours, elicited an increase in immunoreactive somatostatin (IR-SS) release to the media and SS mRNA levels, suggesting that somatostatin secretion can be coupled to SS mRNA accumulation.

Positive_regulation (accumulation) of SS mRNA associated with somatostatin

5) Confidence 0.18 Published 1993 Journal J Pediatr Endocrinol Section Abstract Doc Link 7920985 Disease Relevance 0 Pain Relevance 0.32

In contrast, Na+ channel blockade by tetrodotoxin (TTX) did not modify the 24 h potassium-induced increase in SS mRNA.

Positive_regulation (increase) of SS mRNA associated with tetrodotoxin

6) Confidence 0.15 Published 1993 Journal J Pediatr Endocrinol Section Abstract Doc Link 7920985 Disease Relevance 0 Pain Relevance 0.31

In control animals, a differential distribution of neuropeptide was found; SP and CGRP content increased from C4 to C7 in contrast to SS content, which decreased from C4 to C7.

Positive_regulation (increased) of SS associated with somatostatin, neuropeptide, calcitonin gene-related peptide and substance p

7) Confidence 0.14 Published 1991 Journal Brain Res. Section Abstract Doc Link 1723340 Disease Relevance 0.25 Pain Relevance 1.15

For some statistical software, the default SS will have to be changed to 'Type I' before the analysis is carried out.

Positive_regulation (changed) of SS

8) Confidence 0.13 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2496911 Disease Relevance 0 Pain Relevance 0

Acute administration of CLO significantly decreased hypothalamic GHRH content [leaving unaltered GHRH messenger RNA (mRNA) levels] and increased plasma GH levels; hypothalamic SS content/mRNA levels and pituitary GH content/mRNA levels remained unchanged.

Neg (unchanged) Positive_regulation (unchanged) of SS in pituitary associated with somatostatin and clonidine

9) Confidence 0.08 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 0.82

Blot analysis of total RNA showed increases in SS mRNA in striatum, frontal cortex and hippocampus of animals receiving only a single stimulation as well as kindled animals--the increase occurred 1-3 days following stimulation and levels were back to basal by 1 week.

Positive_regulation (increases) of SS mRNA in frontal cortex associated with somatostatin, urological neuroanatomy and hippocampus

10) Confidence 0.07 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684628 Disease Relevance 0.10 Pain Relevance 0.34

Blot analysis of total RNA showed increases in SS mRNA in striatum, frontal cortex and hippocampus of animals receiving only a single stimulation as well as kindled animals--the increase occurred 1-3 days following stimulation and levels were back to basal by 1 week.

Positive_regulation (increases) of SS mRNA in striatum associated with somatostatin, urological neuroanatomy and hippocampus

11) Confidence 0.07 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684628 Disease Relevance 0.10 Pain Relevance 0.34

SS mRNA and peptide decreased over this developmental time course in cerebellar astrocytes; the time course of changes in SS mRNA paralleled that for rat cerebellum.

Positive_regulation (changes) of SS mRNA in astrocytes associated with somatostatin

12) Confidence 0.03 Published 1992 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1355015 Disease Relevance 0 Pain Relevance 0.50

After peripheral noxious stimulation of unmyelinated nociceptors the release of calcitonin gene-related peptide (CGRP) [7], substance P (SP) [8] and somatostatin (SS) [4,9] is increased although it remains largely unchanged after innocuous stimulation or stimulation of large myelinated fibres [8,9].

Positive_regulation (increased) of SS in nociceptors associated with nociceptor, somatostatin, unmyelinated, substance p and calcitonin gene-related peptide

13) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.71 Pain Relevance 1.19

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