INT76958

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 5.48
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)
Anatomy Link Frequency
skin 3
liver 1
hepatocyte 1
colon 1
stem cell 1
Ctnnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 1 87.60 High High
Pain 1 86.08 High High
cINOD 6 80.08 Quite High
chemokine 3 77.88 Quite High
COX-2 inhibitor 2 76.00 Quite High
aspirin 3 50.00 Quite Low
Paracetamol 2 44.80 Quite Low
COX2 1 25.00 Low Low
metalloproteinase 1 13.04 Low Low
agonist 6 5.60 Low Low
Disease Link Frequency Relevance Heat
Aberrant Crypt Foci 6 99.84 Very High Very High Very High
Liver Cancer 2 99.16 Very High Very High Very High
Polyps 5 99.12 Very High Very High Very High
Cancer 74 98.44 Very High Very High Very High
Targeted Disruption 168 98.08 Very High Very High Very High
Adenoma 4 96.60 Very High Very High Very High
Intestinal Cancer 5 94.48 High High
Colon Cancer 14 93.92 High High
Metastasis 3 90.08 High High
Lung Cancer 32 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apc mutation increases cytoplasmic beta-catenin, a regulatory protein associated with the cytoskeleton.
Positive_regulation (increases) of beta-catenin
1) Confidence 0.64 Published 1998 Journal Surgery Section Body Doc Link 9706142 Disease Relevance 0.09 Pain Relevance 0
The presence of genetic alterations resulting in constitutive beta-catenin stabilization in human and murine liver tumors also implicates this pathway in hepatocyte proliferation.
Positive_regulation (stabilization) of beta-catenin in hepatocyte associated with liver cancer
2) Confidence 0.46 Published 2006 Journal Hepatology Section Abstract Doc Link 16557553 Disease Relevance 0.38 Pain Relevance 0
Conditional knockout mice were born at the expected Mendelian ratio and developed normally to adulthood, indicating beta-catenin is dispensable for essential liver function under normal breeding conditions.
Positive_regulation (dispensable) of beta-catenin in liver associated with targeted disruption
3) Confidence 0.46 Published 2006 Journal Hepatology Section Abstract Doc Link 16557553 Disease Relevance 0.52 Pain Relevance 0
This effect occurred despite loss of Apc heterozygosity and beta-catenin activation.
Positive_regulation (activation) of beta-catenin
4) Confidence 0.37 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18451151 Disease Relevance 0.93 Pain Relevance 0.07
Importantly, mPGES-1 deletion also blocked the nuclear accumulation of beta-catenin in ACF, confirming that beta-catenin is a critical target of PGE(2) procarcinogenic signaling in the colon.
Positive_regulation (accumulation) of beta-catenin in colon associated with aberrant crypt foci
5) Confidence 0.27 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18451151 Disease Relevance 0.90 Pain Relevance 0.17
The proangiogenic protein vascular derived endothelial growth factor was decreased in polyps treated with rofecoxib, whereas membrane-associated beta-catenin increased in rofecoxib-treated polyps.
Positive_regulation (increased) of beta-catenin associated with polyps
6) Confidence 0.12 Published 2003 Journal Am. J. Clin. Oncol. Section Abstract Doc Link 12902858 Disease Relevance 0.90 Pain Relevance 0.13
In normal cycling hairs, the beta-catenin pathway is activated as quiescent hair follicle stem cells enter cycle to become active progenitors, whereas suppression of Wnt signaling is thought to take place in the quiescent multipotent stem cells.
Positive_regulation (activated) of beta-catenin in multipotent stem cells
7) Confidence 0.11 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.10 Pain Relevance 0
The striking similarities between their gene expression programs and the fact that TERT expression phenocopies beta-catenin in skin suggest the possibility that TERT impinges upon the Wnt pathway (see Text S1 and Table S10 for additional details).
Positive_regulation (phenocopies) of beta-catenin in skin
8) Confidence 0.11 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.09 Pain Relevance 0
Interestingly, the effects of conditional beta-catenin activation in skin closely mimic those of TERT.
Positive_regulation (activation) of beta-catenin in skin
9) Confidence 0.10 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.08 Pain Relevance 0
Wnt is a secreted morphogen that initiates a signaling cascade leading to stabilization of beta-catenin, a protein that transactivates promoters bound by the transcription factors TCF or LEF1 [44].
Positive_regulation (stabilization) of beta-catenin
10) Confidence 0.10 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0 Pain Relevance 0
Activation of a beta-catenin-estrogen receptor fusion protein in skin initiated a new anagen cycle [45].
Positive_regulation (Activation) of beta-catenin in skin
11) Confidence 0.10 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.08 Pain Relevance 0
For example, by stabilizing the transcriptional activator beta-catenin, secreted Wnt glycoproteins transduce signals that are required for hair follicle development and differentiation, stem cell activation and stem cell maintenance [12–15].
Positive_regulation (stabilizing) of beta-catenin in stem cell
12) Confidence 0.10 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.09 Pain Relevance 0
This, in turn, results in reduced levels of the cytoplasmic dishevelled protein that activates destruction of the beta-catenin complex.
Positive_regulation (activates) of beta-catenin
13) Confidence 0.03 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.42 Pain Relevance 0
and breast, and that this effect was linked to increased beta-catenin and c-Myc
Positive_regulation (increased) of beta-catenin
14) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 0.91 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox