INT76960

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.46
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)
Anatomy Link Frequency
Liver 1
Ctnnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 9 87.28 High High
aspirin 3 50.00 Quite Low
Paracetamol 1 45.40 Quite Low
COX2 3 25.00 Low Low
Central nervous system 9 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intestinal Cancer 13 98.88 Very High Very High Very High
Cancer 87 97.84 Very High Very High Very High
Metastasis 76 94.96 High High
Adenoma 4 88.96 High High
Stress 1 87.32 High High
Liver Cancer 1 87.04 High High
Adhesions 11 86.00 High High
Targeted Disruption 6 81.48 Quite High
Colon Cancer 1 74.12 Quite High
Apoptosis 5 72.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice.
Negative_regulation (loss) of beta-catenin in Liver
1) Confidence 0.57 Published 2006 Journal Hepatology Section Title Doc Link 16557553 Disease Relevance 0.44 Pain Relevance 0
Finally, aspirin produced a decrease in intracellular beta-catenin levels, suggesting that modulation of this protein is associated with tumor prevention.
Negative_regulation (decrease) of beta-catenin
2) Confidence 0.54 Published 1998 Journal Surgery Section Body Doc Link 9706142 Disease Relevance 0.07 Pain Relevance 0
There was a > or = 50% decrease in beta-catenin (P = 0.001) and diminishing Bcl-2 (P = 0.019) in small intestinal tumors harvested between 2 and 4 days of treatment when compared with untreated controls.
Negative_regulation (decrease) of beta-catenin associated with intestinal cancer
3) Confidence 0.39 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.94 Pain Relevance 0.26
There was a > or = 50% decrease in beta-catenin (P = 0.001) and diminishing Bcl-2 (P = 0.019) in small intestinal tumors harvested between 2 and 4 days of treatment when compared with untreated controls.
Negative_regulation (diminishing) of beta-catenin associated with intestinal cancer
4) Confidence 0.39 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.94 Pain Relevance 0.27
The loss of function in E-cadherin through the disruption of alpha-catenin and/or beta-catenin is well known [1].
Negative_regulation (disruption) of beta-catenin
5) Confidence 0.02 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 1.07 Pain Relevance 0

General Comments

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