INT7697

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Context Info
Confidence 0.68
First Reported 1981
Last Reported 2006
Negated 0
Speculated 2
Reported most in Abstract
Documents 22
Total Number 24
Disease Relevance 2.30
Pain Relevance 9.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adra1a) plasma membrane (Adra1a) cellular_component (Adra1a)
response to stress (Adra1a) signal transducer activity (Adra1a)
Anatomy Link Frequency
nerve 3
ASM 1
Tail 1
spinal cord 1
thoracic 1
Adra1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 42 100.00 Very High Very High Very High
antagonist 32 100.00 Very High Very High Very High
GABAergic 4 100.00 Very High Very High Very High
agonist 37 99.96 Very High Very High Very High
Pain 19 99.92 Very High Very High Very High
noradrenaline 9 99.84 Very High Very High Very High
depression 2 99.64 Very High Very High Very High
Calcium channel 6 99.50 Very High Very High Very High
tolerance 1 96.56 Very High Very High Very High
adenocard 2 94.90 High High
Disease Link Frequency Relevance Heat
Pain 17 99.92 Very High Very High Very High
Depression 2 99.64 Very High Very High Very High
Nervous System Injury 2 98.32 Very High Very High Very High
Nociception 1 98.28 Very High Very High Very High
Hypersensitivity 1 97.48 Very High Very High Very High
Hyperalgesia 9 92.08 High High
Heart Rate Under Development 3 90.24 High High
Bordatella Infection 1 81.72 Quite High
Ganglion Cysts 1 80.68 Quite High
Clostridium Infection 1 71.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present findings show that sialagogue responses to sympathomimetic agents are mediated by alpha-1 adrenoceptor activation in both innervated and denervated submaxillary glands.
Positive_regulation (activation) of alpha-1 adrenoceptor in submaxillary glands
1) Confidence 0.68 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6323688 Disease Relevance 0 Pain Relevance 0.15
It is proposed that the excitatory action of norepinephrine is independent of smooth muscle activity, and is mediated by activation of alpha 1-adrenergic receptors located on the aortic baroreceptor nerve endings.
Positive_regulation (activation) of alpha 1-adrenergic in nerve
2) Confidence 0.65 Published 1984 Journal Circ. Res. Section Abstract Doc Link 6086171 Disease Relevance 0 Pain Relevance 0.18
These results indicate the existence of the presynaptic NPY- and Gal-receptors on noradrenergic nerve terminals, which may enhance the presynaptic alpha-adrenoceptor function to inhibit NE release.
Spec (may) Positive_regulation (enhance) of alpha-adrenoceptor in nerve
3) Confidence 0.52 Published 1990 Journal Am. J. Hypertens. Section Abstract Doc Link 1699553 Disease Relevance 0 Pain Relevance 0.73
Chronic denervation of the vas deferens resulted in significant postsynaptic supersensitivity to alpha 1-adrenoceptor agonists but not to NKA.
Positive_regulation (supersensitivity) of alpha 1-adrenoceptor in vas deferens associated with agonist
4) Confidence 0.48 Published 1992 Journal Gen. Pharmacol. Section Abstract Doc Link 1355059 Disease Relevance 0 Pain Relevance 0.25
Different types of neuroleptics were studied for pre- and postsynaptic alpha-adrenoceptor antagonism in pithed rats using the blood pressure effect of clonidine as a measure of postsynaptic alpha-adrenoceptor activation and the depression of the heart rate response to electrical stimulation as a measure of presynaptic alpha-adrenoceptor activation.
Positive_regulation (activation) of alpha-adrenoceptor in heart associated with depression and clonidine
5) Confidence 0.47 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6113964 Disease Relevance 0.10 Pain Relevance 0.25
Different types of neuroleptics were studied for pre- and postsynaptic alpha-adrenoceptor antagonism in pithed rats using the blood pressure effect of clonidine as a measure of postsynaptic alpha-adrenoceptor activation and the depression of the heart rate response to electrical stimulation as a measure of presynaptic alpha-adrenoceptor activation.
Positive_regulation (activation) of alpha-adrenoceptor in blood associated with depression and clonidine
6) Confidence 0.47 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6113964 Disease Relevance 0.10 Pain Relevance 0.22
The L-type calcium channel current is increased by alpha-1 adrenoceptor activation in neonatal rat ventricular cells.
Positive_regulation (activation) of alpha-1 adrenoceptor associated with calcium channel
7) Confidence 0.47 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7965815 Disease Relevance 0 Pain Relevance 0.38
Our results indicate that the alpha1-adrenoceptor activation: (i) affects both the central respiratory command (i.e. respiratory period and inspiratory burst duration) and spinal inspiratory outputs; (ii) induces slow spinal motor rhythmicity, which is unlikely to be related to the respiratory system; and (iii), increases motoneuronal excitability, probably through a decrease in postsynaptic leak K+ conductance.
Positive_regulation (activation) of alpha1-adrenoceptor in respiratory system
8) Confidence 0.46 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10971636 Disease Relevance 0 Pain Relevance 0.17
The alpha 1-adrenoreceptor is stimulated preferentially by methoxamine and cirazoline and blocked selectively by prazosin or corynanthine.
Positive_regulation (stimulated) of alpha 1-adrenoreceptor
9) Confidence 0.46 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6210422 Disease Relevance 0.06 Pain Relevance 0.35
Therefore, the authors examined the subtype of alpha adrenoceptor activated by clonidine and ST 91 in normal rats and those with nerve injury-induced hypersensitivity.
Spec (examined) Positive_regulation (activated) of alpha adrenoceptor in nerve associated with nervous system injury, hypersensitivity and clonidine
10) Confidence 0.42 Published 2002 Journal Anesthesiology Section Abstract Doc Link 12218531 Disease Relevance 0.36 Pain Relevance 0.83
Reduction of cardiac outward currents by alpha-1 adrenoceptor stimulation: a subtype-specific effect?
Positive_regulation (stimulation) of alpha-1 adrenoceptor
11) Confidence 0.34 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1682485 Disease Relevance 0 Pain Relevance 0.15
Therefore, stimulation of both alpha-1 adrenoceptor subtypes contributes to the phenylephrine-induced reduction in transient outward currents of isolated rat myocytes.
Positive_regulation (stimulation) of alpha-1 adrenoceptor in myocytes
12) Confidence 0.34 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1682485 Disease Relevance 0 Pain Relevance 0.19
Centrally acting imidazolines stimulate vascular alpha 1A-adrenergic receptors in Rat-Tail Artery.
1.
Positive_regulation (stimulate) of alpha 1A in Tail
13) Confidence 0.33 Published 2006 Journal Cell. Mol. Neurobiol. Section Title Doc Link 16897362 Disease Relevance 0 Pain Relevance 0.26
In the spinal cord, activation of DNIN leads to the release of norepinephrine, which inhibits nociceptive processing through direct activation of alpha2 adrenoceptor and indirect activation of GABAergic neurons through alpha1 adrenoceptor.
Positive_regulation (activation) of alpha1 adrenoceptor in spinal cord associated with nociception and gabaergic
14) Confidence 0.31 Published 2003 Journal Anesthesiology Section Abstract Doc Link 12717145 Disease Relevance 0.10 Pain Relevance 0.51
Beta1-adrenoceptor or alpha1-adrenoceptor activation initiates early odor preference learning in rat pups: support for the mitral cell/cAMP model of odor preference learning.
Positive_regulation (activation) of alpha1-adrenoceptor
15) Confidence 0.27 Published 2006 Journal Learn. Mem. Section Title Doc Link 16452650 Disease Relevance 0 Pain Relevance 0.29
Verapamil and nifedipine considerably diminished the increase in serum corticosterone level induced by icv phenylephrine, an alpha 1-adrenergic receptor agonists.
Positive_regulation (induced) of alpha 1-adrenergic associated with agonist
16) Confidence 0.25 Published 1993 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 8102911 Disease Relevance 0 Pain Relevance 0.55
The supposed alpha-2 selective agonist clonidine also produced a concentration-dependent, prazosin-sensitive, yohimbine-resistant relaxation which was markedly greater in control than BAC-treated jejunum, consistent with alpha-1 receptor stimulation.
Positive_regulation (stimulation) of alpha-1 receptor in jejunum associated with agonist and clonidine
17) Confidence 0.25 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2876094 Disease Relevance 0 Pain Relevance 0.47
Spontaneous discharges produced by either picrotoxin or 7.5 mM [K+]o were slowed or stopped by alpha-adrenergic receptor activation, the alpha 1 receptor being most responsible for this slowing effect.
Positive_regulation (activation) of alpha 1 receptor
18) Confidence 0.18 Published 1995 Journal Epilepsy Res. Section Abstract Doc Link 7750509 Disease Relevance 0 Pain Relevance 0.34
In the dog mesenteric and carotid arteries and in the rabbit, guinea pig and rat thoracic aortae, KT-611 competitively inhibited alpha 1-adrenoceptor-mediated contractions induced by noradrenaline with pA2 values ranging from 6.73 to 8.15.
Positive_regulation (induced) of alpha 1-adrenoceptor-mediated in thoracic associated with noradrenaline
19) Confidence 0.17 Published 1991 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1677438 Disease Relevance 0 Pain Relevance 0.13
Selective alpha 1-adrenoceptor antagonists, which can be used as antihypertensives, cause dilation of both resistance and capacitance vessels, as a result of alpha 1-adrenoceptor blockade at postsynaptic sites.
Positive_regulation (cause) of alpha 1-adrenoceptor in vessels associated with antagonist
20) Confidence 0.10 Published 1988 Journal J Hypertens Suppl Section Abstract Doc Link 2906698 Disease Relevance 0.16 Pain Relevance 0.15

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