INT76993

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Context Info
Confidence 0.60
First Reported 1998
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 7.81
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HRAS) signal transduction (HRAS) Golgi apparatus (HRAS)
plasma membrane (HRAS) nucleus (HRAS) GTPase activity (HRAS)
Anatomy Link Frequency
hip 1
pancreas 1
HRAS (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 22 99.92 Very High Very High Very High
fibrosis 63 98.96 Very High Very High Very High
Chronic pancreatitis 5 98.90 Very High Very High Very High
palliative 1 98.88 Very High Very High Very High
Osteoarthritis 47 98.32 Very High Very High Very High
Pain 28 97.04 Very High Very High Very High
metalloproteinase 1 86.96 High High
Potency 16 81.96 Quite High
imagery 3 74.48 Quite High
Inflammation 3 62.96 Quite High
Disease Link Frequency Relevance Heat
Cancer 21 99.60 Very High Very High Very High
Pancreatic Cancer 16 99.58 Very High Very High Very High
Cirrhosis 67 99.40 Very High Very High Very High
Pressure Volume 2 Under Development 1 99.40 Very High Very High Very High
Pancreatitis 5 98.90 Very High Very High Very High
Adenocarcinoma 2 98.40 Very High Very High Very High
Osteoarthritis 46 98.32 Very High Very High Very High
Hyperplasia 1 98.08 Very High Very High Very High
Adenoma 1 97.50 Very High Very High Very High
Colon Cancer 1 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the most promising are farnesyl protein transferase inhibitors, which modulate K-ras function.
Regulation (modulate) of K-ras
1) Confidence 0.60 Published 2002 Journal Can. J. Gastroenterol. Section Abstract Doc Link 11875597 Disease Relevance 0.68 Pain Relevance 0.12
Although positive K-ras point mutation has been reported in some cases of adenoma or mucinous cell hyperplasia of the pancreas and chronic pancreatitis, our case, along with previous reports, indicated the importance of testing K-ras point mutation in pure pancreatic juices for the diagnosis of pancreatic cancer at an early stage.
Regulation (importance) of K-ras in pancreas associated with adenoma, pancreatic cancer, chronic pancreatitis and hyperplasia
2) Confidence 0.44 Published 1998 Journal Am. J. Gastroenterol. Section Abstract Doc Link 9707068 Disease Relevance 0.87 Pain Relevance 0.13
Gene therapy with p53 and K-ras modulated herpesviruses may become a palliative treatment option and can be administered easily by regional chemotherapy techniques [23].
Regulation (modulated) of K-ras associated with palliative
3) Confidence 0.26 Published 2002 Journal Hematol. Oncol. Clin. North Am. Section Abstract Doc Link 12063827 Disease Relevance 0.19 Pain Relevance 0.10
Many studies have investigated tumor-mediated molecular alterations of the pancreatic juice, as k-ras mutations, telomerase reactivation, or promoter methylation of the tumor-suppressor genes p16INK4a and p14ARF.
Spec (investigated) Regulation (alterations) of k-ras associated with cancer
4) Confidence 0.26 Published 2004 Journal Dig Dis Section Abstract Doc Link 15753605 Disease Relevance 0.79 Pain Relevance 0.09
Pancreatic cancer is characterized by alterations in K-Ras, INK4a, Tp53 and SMAD4.
Regulation (alterations) of K-Ras associated with pancreatic cancer
5) Confidence 0.26 Published 2006 Journal Praxis Section Abstract Doc Link 17111879 Disease Relevance 1.39 Pain Relevance 0.15
The study also investigates whether alterations of p21ras occur in K-ras mutation-negative cases by using immunohistochemical staining for K-, N- and H-ras.
Spec (whether) Regulation (alterations) of p21ras
6) Confidence 0.15 Published 1999 Journal Hum. Pathol. Section Abstract Doc Link 10374765 Disease Relevance 1.48 Pain Relevance 0.25
The value of human albumin (HA) for treating hypovolemia is controversial.
Regulation (value) of HA associated with pressure volume 2 under development
7) Confidence 0.06 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16790652 Disease Relevance 0.22 Pain Relevance 0.03
To our knowledge there are no clinical studies which compare the effects of HA, CS and bupivacaine in patients with hip OA.


Regulation (effects) of HA in hip associated with corticosteroid and osteoarthritis
8) Confidence 0.02 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998460 Disease Relevance 0.58 Pain Relevance 0.60
In case no structural alterations in HA are detected by SRID this does not guarantee a complete absence of conformational changes, since the method may not reveal every structural change.
Neg (no) Regulation (alterations) of HA
9) Confidence 0.01 Published 2008 Journal Pharm Res Section Body Doc Link PMC2346510 Disease Relevance 0.08 Pain Relevance 0.08
The highest values of HA were found in cirrhotic patients.
Regulation (values) of HA associated with cirrhosis
10) Confidence 0.00 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2936897 Disease Relevance 1.53 Pain Relevance 0.42

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