INT76994

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.75
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
hippocampus 4
brain structures 2
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 19 100.00 Very High Very High Very High
Hippocampus 2 99.68 Very High Very High Very High
opioid receptor 4 91.20 High High
long-term potentiation 6 89.68 High High
Calcium channel 2 86.44 High High
potassium channel 2 85.04 High High
Kappa opioid receptor 3 82.36 Quite High
Hyperalgesia 2 78.28 Quite High
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 2 91.04 High High
Targeted Disruption 5 87.68 High High
Hyperalgesia 2 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, ORL1 receptor expression was down-regulated in virtually all brain structures in heterozygous kappa-knockouts although the magnitude of this change was not as great as for the delta-knockouts.
Negative_regulation (down) of Gene_expression (expression) of ORL1 in brain structures
1) Confidence 0.59 Published 2001 Journal Neuroscience Section Abstract Doc Link 11591451 Disease Relevance 0.24 Pain Relevance 0.31
Histological analysis revealed the expression of both the nociceptin precursor and the nociceptin receptor in the hippocampus, thought to take part in aspects of learning and memory.
Negative_regulation (revealed) of Gene_expression (expression) of nociceptin precursor in hippocampus associated with orphanin and hippocampus
2) Confidence 0.42 Published 1998 Journal Nature Section Abstract Doc Link 9707118 Disease Relevance 0.26 Pain Relevance 0.71
Histological analysis revealed the expression of both the nociceptin precursor and the nociceptin receptor in the hippocampus, thought to take part in aspects of learning and memory.
Negative_regulation (revealed) of Gene_expression (expression) of nociceptin receptor in hippocampus associated with orphanin and hippocampus
3) Confidence 0.42 Published 1998 Journal Nature Section Abstract Doc Link 9707118 Disease Relevance 0.26 Pain Relevance 0.71

General Comments

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