INT770

Context Info Confidence 0.61 First Reported 1975 Last Reported 2006 Negated 5 Speculated 14 Reported most in Abstract Documents 127 Total Number 141 Disease Relevance 17.91 Pain Relevance 58.23

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)

Anatomy Link Frequency pituitary 12 brain 8 thyroid 7 hypothalamus 5 blood 4 Gnrhr (Rattus norvegicus)

Pain Link Frequency Relevance Heat Clonidine 268 100.00 Morphine 124 100.00 agonist 91 100.00 Somatostatin 89 100.00 narcan 79 100.00 antagonist 73 100.00 Serotonin 59 100.00 opiate 51 100.00 Opioid 39 100.00 substance P 38 100.00

Disease Link Frequency Relevance Heat Stress 93 100.00 Obesity 37 100.00 Shock 13 100.00 Morphine Dependence 6 100.00 Disease 6 100.00 Sleep Disorders 4 100.00 Thyroid Disease 2 100.00 Xerostomia 1 100.00 Galactorrhea 9 99.84 Hypotension 8 99.80

Sentences Mentioned In

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Event

Anatomy

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[The effect of anesthetics on the basal secretion of immunoreactive growth hormone in rats].

Regulation (effect) of Localization (secretion) of immunoreactive growth hormone

1) Confidence 0.61 Published 1978 Journal C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. Section Title Doc Link 100239 Disease Relevance 0.08 Pain Relevance 0.08

It is well documented that gonadotropin-releasing hormone (GnRH) release is negatively regulated by opiates.

Regulation (regulated) of Localization (release) of gonadotropin-releasing hormone associated with opiate

2) Confidence 0.61 Published 1993 Journal Neuroreport Section Abstract Doc Link 8477057 Disease Relevance 0 Pain Relevance 0.80

Because growth hormone secretion is regulated by monoamine neurotransmitters, hyposecretion of growth hormone may reflect generalized changes in the neurochemical substrate of this disorder.

Regulation (regulated) of Localization (secretion) of growth hormone associated with neurotransmitter and monoamine

3) Confidence 0.58 Published 1988 Journal Endocrinol. Metab. Clin. North Am. Section Abstract Doc Link 2897907 Disease Relevance 0.17 Pain Relevance 0.20

Because growth hormone secretion is regulated by monoamine neurotransmitters, hyposecretion of growth hormone may reflect generalized changes in the neurochemical substrate of this disorder.

Regulation (regulated) of Localization (secretion) of growth hormone associated with neurotransmitter and monoamine

4) Confidence 0.58 Published 1988 Journal Neurol Clin Section Abstract Doc Link 3380074 Disease Relevance 0.17 Pain Relevance 0.20

The role of brain catecholamines in the regulation of growth hormone secretion was investigated in pentobarbital-anesthetized dogs by using drugs which modify the function of adrenergic neurons and receptors.

Regulation (regulation) of Localization (secretion) of growth hormone in adrenergic neurons associated with catecholamine

5) Confidence 0.55 Published 1976 Journal Neuroscience Section Abstract Doc Link 11370235 Disease Relevance 0 Pain Relevance 0.21

However, this study demonstrates no effect of chronic clonidine therapy on growth hormone release.

Neg (no) Regulation (effect) of Localization (release) of growth hormone associated with clonidine

6) Confidence 0.52 Published 1981 Journal J Clin Pharmacol Section Abstract Doc Link 7217341 Disease Relevance 0.23 Pain Relevance 0.43

The effect of repeated electroconvulsive shocks (ECS) on growth hormone (GH) secretion was studied in rats.

Regulation (effect) of Localization (secretion) of growth hormone associated with shock

7) Confidence 0.50 Published 1982 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6805018 Disease Relevance 0.53 Pain Relevance 0.19

The effect of repeated electroconvulsive shocks on growth hormone secretion and growth hormone responses to clonidine in the intact rat.

Regulation (effect) of Localization (secretion) of growth hormone associated with shock and clonidine

8) Confidence 0.50 Published 1982 Journal Psychopharmacology (Berl.) Section Title Doc Link 6805018 Disease Relevance 0.55 Pain Relevance 0.22

This study was conducted in order to further understand whether the effect of opiates on growth hormone and prolactin release was exerted centrally or at least in part peripherally.

Spec (whether) Regulation (effect) of Localization (release) of growth hormone associated with opiate

9) Confidence 0.46 Published 1981 Journal Endocrinology Section Abstract Doc Link 7227313 Disease Relevance 0 Pain Relevance 0.76

To investigate the mechanisms subserving the reported reduced pulsatile release of gonadotropin-releasing hormone (GnRH) in chronic renal failure, this study examined the amino acid neurotransmitter milieu in the medial preoptic area (MPOA), the hypothalamic region where the GnRH-secreting neurons reside, in 5/6-nephrectomized male rats and in ad libitum-fed or pair-fed controls.

Spec (investigate) Regulation (pulsatile) of Localization (release) of gonadotropin-releasing hormone in medial associated with neurotransmitter, chronic renal failure and urological neuroanatomy

10) Confidence 0.45 Published 2001 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 11373345 Disease Relevance 0.71 Pain Relevance 0.15

The conventional benzodiazepine diazepam and the novel triazolobenzodiazepine alprazolam were compared with respect to effects on growth hormone (GH) release in reserpine pretreated rats.

Regulation (effects) of Localization (release) of growth hormone

11) Confidence 0.42 Published 1986 Journal Life Sci. Section Abstract Doc Link 2871466 Disease Relevance 0 Pain Relevance 0.26

Does alprazolam, in contrast to diazepam, activate alpha 2-adrenoceptors involved in the regulation of rat growth hormone secretion?

Regulation (regulation) of Localization (secretion) of growth hormone

12) Confidence 0.42 Published 1986 Journal Life Sci. Section Title Doc Link 2871466 Disease Relevance 0 Pain Relevance 0.34

Fluoxetine pretreatment increased the serum corticosterone to the same level as did d-fenfluramine. d-Fenfluramine's effect on prolactin and growth hormone release was further tested in a hypothalamic-pituitary in vitro system.

Regulation (effect) of Localization (release) of growth hormone in pituitary associated with fluoxetine

13) Confidence 0.41 Published 1987 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 3449200 Disease Relevance 0 Pain Relevance 0.26

The mechanism of d-fenfluramine's effect on corticosterone and growth hormone release needs further evaluation.

Regulation (effect) of Localization (release) of growth hormone

14) Confidence 0.41 Published 1987 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 3449200 Disease Relevance 0 Pain Relevance 0.16

Effects of the synthesized growth hormone releasing peptide, KP-102, on growth hormone release in sodium glutamate monohydrate-treated low growth rats.

Regulation (Effects) of Localization (release) of growth hormone associated with glutamate

15) Confidence 0.41 Published 1996 Journal Life Sci. Section Title Doc Link 8761023 Disease Relevance 0.18 Pain Relevance 0.33

Maturation of central nervous system control of growth hormone secretion in rats.

Regulation (control) of Localization (secretion) of growth hormone in central nervous system associated with central nervous system

16) Confidence 0.41 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 6970810 Disease Relevance 0 Pain Relevance 0.47

Infusion of IL-1 beta into the PVN does not induce measurable changes in release of gonadotropin-releasing hormone (GnRH), but infusion of IL-1 directly into the median preoptic area (MPOA), a region rich in GnRH perikarya, markedly decreases GnRH secretion in rats bearing a push-pull cannula in the median eminence.

Neg (not) Regulation (changes) of Localization (release) of gonadotropin-releasing hormone in MPOA

17) Confidence 0.40 Published 1993 Journal Ciba Found. Symp. Section Abstract Doc Link 8491087 Disease Relevance 0 Pain Relevance 0.19

Intravenous injection of dermorphin in pharmacological doses did not affect prolactin and growth hormone release or serum glucose.

Neg (not) Regulation (affect) of Localization (release) of growth hormone

18) Confidence 0.39 Published 1983 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6870393 Disease Relevance 0 Pain Relevance 0.10

Effects of the centrally acting alpha-adrenergic agonist, clonidine, on growth hormone (GH) secretion was studied in conscious male rats pretreated with monosodium glutamate (MSG) during the neonatal period.

Regulation (Effects) of Localization (secretion) of growth hormone associated with glutamate, agonist and clonidine

19) Confidence 0.39 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6320028 Disease Relevance 0.07 Pain Relevance 0.43

Effect of neurotensin, substance P and morphine sulfate on the secretion of prolactin and growth hormone in the rat.

Regulation (Effect) of Localization (secretion) of growth hormone associated with narcan, morphine and substance p

20) Confidence 0.39 Published 1977 Journal Endocrinology Section Title Doc Link 95701 Disease Relevance 0 Pain Relevance 0.77

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