INT77000

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Context Info
Confidence 0.04
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.57
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgg) extracellular space (Fgg) extracellular region (Fgg)
protein binding, bridging (Fgg)
Anatomy Link Frequency
cleavage 2
blood 1
FDPp 1
platelet 1
astrocytes 1
Fgg (Mus musculus)
Pain Link Frequency Relevance Heat
cva 11 98.84 Very High Very High Very High
Inflammation 67 91.72 High High
cytokine 38 89.20 High High
Inflammatory response 29 87.28 High High
chemokine 6 82.56 Quite High
Pain 5 73.88 Quite High
colic 1 64.32 Quite High
dexamethasone 3 49.12 Quite Low
ischemia 17 45.60 Quite Low
cINOD 5 41.68 Quite Low
Disease Link Frequency Relevance Heat
Shock 5 99.78 Very High Very High Very High
Coagulation Disorder 41 99.42 Very High Very High Very High
Cv General 3 Under Development 7 98.84 Very High Very High Very High
Arrhythmias 2 Under Development 1 97.92 Very High Very High Very High
Abscess 126 97.08 Very High Very High Very High
Infection 50 92.00 High High
INFLAMMATION 117 91.72 High High
Disseminated Intravascular Coagulation 2 89.32 High High
Bacteremia 20 85.20 High High
Sepsis 111 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of various toll like receptors (TLR) on astrocytes endows the ability to recognize not only bacterial and viral signals but also endogenous "danger" signals such as heat shock proteins, fibrinogen degradation products, and free DNA [30].
Protein_catabolism (degradation) of fibrinogen in astrocytes associated with shock
1) Confidence 0.04 Published 2007 Journal J Transl Med Section Body Doc Link PMC1914111 Disease Relevance 0.70 Pain Relevance 0.18
Coa and vWbp promote the non-proteolytic activation of prothrombin and cleavage of fibrinogen, reactions that are inhibited with specific antibody against each of these molecules.
Protein_catabolism (cleavage) of fibrinogen in cleavage
2) Confidence 0.03 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2916881 Disease Relevance 0.67 Pain Relevance 0
The D1 and D2 domains of vWbp display 30% amino acid identity with the corresponding domain of coagulase and also associate with prothrombin, activating the zymogen and promoting cleavage of fibrinogen to fibrin [24].
Protein_catabolism (cleavage) of fibrinogen in cleavage
3) Confidence 0.03 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.33 Pain Relevance 0
Several activities similar to or directed against blood clotting factors have been identified in LA: fibrinolytic enzymes, which degrade fibrinogen producing abnormal FDPs; prothrombin activators: one direct and one factor Xa-like; a thermostable factor V activator; a thermolabile factor V inhibitor; a factor XIII proteolytic/urokinase-like activity; and a kallikrein-like activitiy.
Protein_catabolism (degrade) of fibrinogen in blood associated with coagulation disorder
4) Confidence 0.02 Published 2000 Journal Biochimie Section Abstract Doc Link 11086223 Disease Relevance 0.63 Pain Relevance 0.11
The procoagulant activities of thrombin include proteolytic
         activation of blood-clotting factors (Va, VIIIa and XI), cleavage of fibrinogen to form a
         fibrin clot, and stimulation of platelet aggregation. 
Protein_catabolism (cleavage) of fibrinogen in platelet associated with coagulation disorder
5) Confidence 0.01 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.68 Pain Relevance 0.08
The authors examined the trend of plasma (FDPp) and urine (FDPu) fibrin-fibrinogen degradation products in a case of renal thromboembolism during atrial fibrillation.
Protein_catabolism (degradation) of fibrin-fibrinogen in FDPp associated with arrhythmias 2 under development and cva
6) Confidence 0.01 Published 1998 Journal Minerva Urol Nefrol Section Abstract Doc Link 9707971 Disease Relevance 0.55 Pain Relevance 0.26

General Comments

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