INT7703

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Context Info
Confidence 0.22
First Reported 1992
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gls)
Anatomy Link Frequency
liver 1
Gls (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 2 96.04 Very High Very High Very High
Physical dependence 3 95.52 Very High Very High Very High
agonist 2 74.80 Quite High
corticosteroid 35 66.44 Quite High
narcan 6 55.44 Quite High
Abstinence syndrome 4 53.68 Quite High
spastic colon 1 42.84 Quite Low
rheumatoid arthritis 1 41.36 Quite Low
Inflammation 1 36.24 Quite Low
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Drug Dependence 3 95.52 Very High Very High Very High
Diabetes Mellitus 2 70.08 Quite High
Insulin Resistance 2 68.32 Quite High
Syndrome 4 52.80 Quite High
Muscle Weakness 1 52.32 Quite High
Increased Venous Pressure Under Development 1 51.48 Quite High
Hypertension 1 49.76 Quite Low
Functional Bowel Disorder 1 42.84 Quite Low
Systemic Lupus Erythematosus 1 41.64 Quite Low
Rheumatoid Arthritis 1 41.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to these five genes, we have defined the “greater urea cycle” and also examined the expression of mRNA for nine additional enzymes that play a role in the disposal of nitrogen in the liver (glutamine synthetase, glutamine dehydrogenase, malate dehydrogenase, carbonic anhydrase, glutaminase, ornithine decarboxylase, tyrosine aminotransferase, aspartate aminotransferase and alanine aminotransferase), and two additional genes involved in transcriptional regulation of those genes; glucocorticoid receptor (GR) and CCAAT/enhancer binding protein (CEBP-?).
Spec (examined) Gene_expression (expression) of glutaminase in liver
1) Confidence 0.22 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0.29 Pain Relevance 0.06
It has previously been shown that subchronic and acute administration of L-asparaginase and glutaminase inhibitors D-Aspartic acid (D-ASP) and prolyl-leucyl-glycinamide (PLG) intensifies and attenuates morphine (M) physical dependence, respectively, by the inhibition of ASP and glutamic acid (GLU) production, and subsequently their normal releases.
Gene_expression (administration) of glutaminase associated with physical dependence and morphine
2) Confidence 0.12 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1355295 Disease Relevance 0.29 Pain Relevance 0.41

General Comments

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