INT77076

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 20
Disease Relevance 13.54
Pain Relevance 5.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppig) protein folding (Ppig) nucleus (Ppig)
cytoplasm (Ppig)
Anatomy Link Frequency
urinary bladder 2
lymph nodes 2
liver 2
1A2 1
iliac 1
Ppig (Mus musculus)
Pain Link Frequency Relevance Heat
depression 42 99.92 Very High Very High Very High
Inflammation 279 99.84 Very High Very High Very High
Paracetamol 39 99.80 Very High Very High Very High
cytokine 136 99.40 Very High Very High Very High
ischemia 5 95.68 Very High Very High Very High
interstitial cystitis 369 94.16 High High
Analgesic 5 91.76 High High
Calcitonin gene-related peptide 7 89.16 High High
chemokine 108 89.00 High High
Inflammatory mediators 9 87.64 High High
Disease Link Frequency Relevance Heat
Toxicity 21 99.98 Very High Very High Very High
Cystitis 630 99.96 Very High Very High Very High
Depression 42 99.92 Very High Very High Very High
INFLAMMATION 285 99.84 Very High Very High Very High
Immunization 10 99.84 Very High Very High Very High
Cataract 8 99.36 Very High Very High Very High
Malaria 225 99.30 Very High Very High Very High
Body Weight 6 99.08 Very High Very High Very High
Infection 332 98.42 Very High Very High Very High
Pressure And Volume Under Development 9 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injection of acetaminophen (APAP) (350 mg/kg body weight) into C57BL/6 mice in which cytochrome P450 (CYP) 1A1/1A2 had been induced produced acute cataract and other ocular tissue damage.
Positive_regulation (induced) of CYP in body associated with paracetamol, body weight and cataract
1) Confidence 0.49 Published 1998 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 9715438 Disease Relevance 0.64 Pain Relevance 0.42
Neither DADS nor NAC inhibited CYP 1A1/1A2 induction as determined by their effect on the induction of hepatic microsomal ethoxyresorufin O-dealkylase (ERD) activity.
Positive_regulation (induction) of CYP in 1A2
2) Confidence 0.45 Published 1998 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 9715438 Disease Relevance 0.67 Pain Relevance 0.52
Taken together, the present study presents a scenario where CYP induction leads to increased numbers of both systemic and mucosal mast cells, partially through CXCL10-CXCR3 interactions.
Positive_regulation (induction) of CYP in mast cells
3) Confidence 0.16 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.95 Pain Relevance 0.52
CYP-induced cystitis and Ab treatment
Positive_regulation (induced) of CYP associated with cystitis
4) Confidence 0.12 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.41 Pain Relevance 0.12
However, increases in serum CXCL10 (and CXCL9) concentrations were significantly reduced following CXCL10 blockade in mice that received CYP.
Positive_regulation (received) of CYP
5) Confidence 0.12 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.95 Pain Relevance 0.23
In the present study, we noticed significant increases in mast cell numbers in the spleen, iliac lymph nodes, and urinary bladder after CYP induction and these increases were abrogated by anti-CXCL10 Ab treatment.
Positive_regulation (induction) of CYP in lymph nodes
6) Confidence 0.11 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.08 Pain Relevance 0.55
CXCL10 blockade reduced the number of splenic, iliac lymph node, and urinary bladder NKT cells after CYP induction as compared to CYP-induced and control Ab treated mice.
Positive_regulation (induction) of CYP in iliac
7) Confidence 0.11 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.00 Pain Relevance 0.42
Mast cells were significantly increased in the spleen, iliac lymph nodes, and urinary bladder after CYP induction than compared to control animals.
Positive_regulation (induction) of CYP in lymph nodes
8) Confidence 0.11 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.62 Pain Relevance 0.17
Serum CXCL9, CXCL10, and CXCL11 levels in mice after CYP induction
Positive_regulation (induction) of CYP
9) Confidence 0.11 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.84 Pain Relevance 0.37
Based on these findings, and also on in vivo experiments in which iNOS inhibitors partially reversed LPS-induced decline of liver CYP activities, Khatsenko et al [16] advanced a hypothesis that NO overproduction mediates the decrease in CYP activities induced by immunostimulation.
Positive_regulation (induced) of CYP in liver associated with immunization
10) Confidence 0.09 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.48 Pain Relevance 0.09
Along this line, it was reported that Plasmodium berghei infection depressed the total content of cytochrome P450s (CYPs) and the expression and activity of several CYP isoforms in the rodent liver [3-6].
Positive_regulation (activity) of CYP in liver associated with infection
11) Confidence 0.06 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.80 Pain Relevance 0.12
The mechanism by which malaria down-modulates the expression and activity of other CYP isoforms is still unclear.
Positive_regulation (activity) of CYP associated with malaria
12) Confidence 0.06 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.97 Pain Relevance 0.15
Nonetheless, the idea that NO mediates a general depression of CYP activities caused by inflammatory and infectious stimuli remains controversial.
Positive_regulation (caused) of CYP associated with inflammation and depression
13) Confidence 0.06 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.54 Pain Relevance 0.10
Several studies have shown that stimulation of host defense mechanisms against infections, as well as treatment with pro-inflammatory cytokines, modulate the expression and activity of cytochrome P450 enzymes (CYP), thereby modifying the kinetics of drugs and toxicants [1,2].
Positive_regulation (activity) of CYP associated with inflammation, infection and cytokine
14) Confidence 0.06 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.63 Pain Relevance 0.10
AP toxicity requires cytochrome P450(CYP)-mediated metabolic activation, and the isozymes CYP1A2, 2E1, and 3A are known to activate AP in the human.
Positive_regulation (requires) of CYP associated with toxicity and paracetamol
15) Confidence 0.05 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9714300 Disease Relevance 0.51 Pain Relevance 0.71
This study suggested that postmitochondrial fractions play an important role in paraquat detoxication metabolism, and that the combination of CYP induction is highly useful for the survival of paraquat-exposed mice.
Positive_regulation (induction) of CYP
16) Confidence 0.04 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.43 Pain Relevance 0.04
In the present study, we noticed significant increases in mast cell numbers in the spleen, iliac lymph nodes, and urinary bladder after CYP induction and these increases were abrogated by anti-CXCL10 Ab treatment.
Positive_regulation (induction) of CYP in urinary bladder
17) Confidence 0.04 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.08 Pain Relevance 0.55
Mast cells were significantly increased in the spleen, iliac lymph nodes, and urinary bladder after CYP induction than compared to control animals.
Positive_regulation (induction) of CYP in urinary bladder
18) Confidence 0.04 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.62 Pain Relevance 0.17
Second, SXR activation directly stimulates the transcription of CYP enzymes in response to the presence of its ligands and plays a central role in the transcriptional regulation of CYP3A4.
Positive_regulation (enzymes) of CYP
19) Confidence 0.03 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.05 Pain Relevance 0.06
Inhibition of COX leads to increased metabolism of AA via LOX and CYP pathways.
Positive_regulation (increased) of CYP
20) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.28 Pain Relevance 0.50

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