INT77083

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Context Info
Confidence 0.20
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
olfactory mucosa 1
Das (Mus musculus)
Cyp2e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 15 95.76 Very High Very High Very High
Analgesic 1 70.28 Quite High
Disease Link Frequency Relevance Heat
Toxicity 6 96.24 Very High Very High Very High
Targeted Disruption 1 90.16 High High
Renal Disease 1 72.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diallyl sulfide (DAS), a known inhibitor of CYP2E1 and of CYP2A10/2A11 (the rabbit orthologue of mouse CYP2A5), completely eliminated olfactory toxicity of AP in both the Cyp1a2(-/-) and wild-type mouse olfactory mucosa.
DAS Negative_regulation (inhibitor) of CYP2E1 in olfactory mucosa associated with toxicity and paracetamol
1) Confidence 0.20 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9714300 Disease Relevance 0.59 Pain Relevance 1.06

General Comments

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