INT77088

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.46
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mrpl14) structural constituent of ribosome (Mrpl14) ribosome (Mrpl14)
translation (Mrpl14)
Anatomy Link Frequency
macrophages 2
peritoneal macrophages 1
Mrpl14 (Mus musculus)
Pain Link Frequency Relevance Heat
IPN 10 98.48 Very High Very High Very High
algogenic 2 95.92 Very High Very High Very High
Inflammation 8 93.84 High High
Antinociceptive 10 90.72 High High
antinociception 6 90.04 High High
Pain 6 84.08 Quite High
Endogenous opioid 1 79.92 Quite High
central pain 2 71.36 Quite High
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 10 98.48 Very High Very High Very High
INFLAMMATION 8 93.84 High High
Pain 4 84.08 Quite High
Peritonitis 5 79.08 Quite High
Nociception 1 67.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 4 h of Cg injection in neutrophil-depleted mice a significant expression of the calcium-binding protein MRP-14 was detected in the cytoplasm of peritoneal macrophages.
Gene_expression (expression) of MRP-14 in peritoneal macrophages
1) Confidence 0.75 Published 2002 Journal Mediators Inflamm Section Abstract Doc Link PMC1781669 Disease Relevance 0.20 Pain Relevance 0.49
Based on these premises and on our previous demonstration that the calcium-binding protein MRP-14, highly expressed in neutrophils, deactivates activated macrophages in vitro, we decided to investigate the role of MRP-14 and of neutrophils in the control of inflammatory pain in mice.
Gene_expression (expressed) of MRP-14 in macrophages associated with ipn
2) Confidence 0.73 Published 1998 Journal J. Leukoc. Biol. Section Abstract Doc Link 9715261 Disease Relevance 0.62 Pain Relevance 0.70
Based on these premises and on our previous demonstration that the calcium-binding protein MRP-14, highly expressed in neutrophils, deactivates activated macrophages in vitro, we decided to investigate the role of MRP-14 and of neutrophils in the control of inflammatory pain in mice.
Gene_expression (expressed) of MRP-14 in macrophages associated with ipn
3) Confidence 0.63 Published 1998 Journal J. Leukoc. Biol. Section Abstract Doc Link 9715261 Disease Relevance 0.65 Pain Relevance 0.77

General Comments

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