INT771

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1977
Last Reported 2010
Negated 15
Speculated 12
Reported most in Abstract
Documents 93
Total Number 106
Disease Relevance 13.13
Pain Relevance 53.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
nucleus 6
nucleus accumbens 6
neuronal 4
striatum 3
cortex 3
Nts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 192 100.00 Very High Very High Very High
Enkephalin 153 100.00 Very High Very High Very High
substance P 129 100.00 Very High Very High Very High
Glutamate 125 100.00 Very High Very High Very High
Neuropeptide 77 100.00 Very High Very High Very High
Somatostatin 60 100.00 Very High Very High Very High
Nucleus accumbens 42 100.00 Very High Very High Very High
Neurotransmitter 35 100.00 Very High Very High Very High
Substantia nigra 28 100.00 Very High Very High Very High
Cholecystokinin 28 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 9 100.00 Very High Very High Very High
Lewy Body Disease 8 100.00 Very High Very High Very High
Pain 191 99.98 Very High Very High Very High
Disease 23 99.92 Very High Very High Very High
Nociception 183 99.20 Very High Very High Very High
INFLAMMATION 51 97.80 Very High Very High Very High
Headache 4 97.16 Very High Very High Very High
Arthritis 3 97.04 Very High Very High Very High
Urological Neuroanatomy 70 96.52 Very High Very High Very High
Stress 15 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dorsal root section produced a 40% loss of opiate receptors throughout layers I and II of the spinal cord whilst no change in neurotensin receptor density or distribution was found.
Neg (no) Regulation (change) of neurotensin in Dorsal root associated with opiate and spinal cord
1) Confidence 0.61 Published 1981 Journal Brain Res. Section Abstract Doc Link 6172180 Disease Relevance 0 Pain Relevance 0.81
Striatal c-fos induction was blocked by local administration of phosphorothioated c-fos antisense oligonucleotides (AS-ODN) to examine the possible role of caffeine-induced c-fos expression in transcriptional regulation of striatal preproenkephalin, prodynorphin, preprotachykinin A and neurotensin/neuromedin N.
Regulation (regulation) of neurotensin/neuromedin N
2) Confidence 0.60 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9421173 Disease Relevance 0 Pain Relevance 0
The peptides neurotensin, enkephalin, neurophysin and bombesin were not affected by capsaicin treatment.
Neg (not) Regulation (affected) of neurotensin associated with qutenza and enkephalin
3) Confidence 0.60 Published 1982 Journal Neuroscience Section Abstract Doc Link 7162630 Disease Relevance 0 Pain Relevance 0.94
However, the fact that METH caused greater increases in Nts transcript levels on the lesioned side suggests that both DA and 5-HT might be involved in regulating Nts transcript levels after injection of METH since methylenedioxymethamphetamine (MDMA) which causes 5-HT release can also increase Nts mRNA levels [50].
Regulation (regulating) of Nts associated with dopamine
4) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.38
Effect of neurotensin and immunneutralization with anti-neurotensin-serum on dopaminergic-cholinergic interaction in the striatum.
Regulation (Effect) of neurotensin in striatum
5) Confidence 0.59 Published 1993 Journal Brain Res. Section Title Doc Link 8101133 Disease Relevance 0 Pain Relevance 0.30
Neurotensin stimulation of both proximal and distal colon was unaffected by tetrodotoxin, phentolamine, propranolol, naloxone, or atropine.
Neg (unaffected) Regulation (unaffected) of Neurotensin in proximal associated with tetrodotoxin and narcan
6) Confidence 0.59 Published 1987 Journal Gastroenterology Section Abstract Doc Link 2887481 Disease Relevance 0.10 Pain Relevance 0.19
Neurotensin levels in substantia nigra were unaffected by the administration of SKF 38393 and SCH 23390, or by quinpirole and sulpiride.
Neg (unaffected) Regulation (unaffected) of Neurotensin in substantia nigra associated with substantia nigra
7) Confidence 0.51 Published 1991 Journal Biochem. Pharmacol. Section Abstract Doc Link 1673340 Disease Relevance 0 Pain Relevance 1.19
Neither quinpirole nor sulpiride altered neurotensin levels in the nucleus accumbens.
Neg (nor) Regulation (altered) of neurotensin in nucleus accumbens associated with nucleus accumbens
8) Confidence 0.51 Published 1991 Journal Biochem. Pharmacol. Section Abstract Doc Link 1673340 Disease Relevance 0 Pain Relevance 1.22
In the nucleus accumbens, the neurotensin content was not affected by administration of SKF 38393 but increased by SCH 23390.
Neg (not) Regulation (affected) of neurotensin in nucleus accumbens associated with nucleus accumbens
9) Confidence 0.51 Published 1991 Journal Biochem. Pharmacol. Section Abstract Doc Link 1673340 Disease Relevance 0 Pain Relevance 1.33
Tetrodotoxin did not affect the responses to neurotensin in the rat ileum and the guinea-pig taenia.
Neg (not) Regulation (affect) of neurotensin in ileum associated with tetrodotoxin
10) Confidence 0.45 Published 1978 Journal Eur. J. Pharmacol. Section Abstract Doc Link 699961 Disease Relevance 0 Pain Relevance 0.20
Effects of neurotensin on isolated intestinal smooth muscles.
Regulation (Effects) of neurotensin in smooth muscles
11) Confidence 0.45 Published 1978 Journal Eur. J. Pharmacol. Section Title Doc Link 699961 Disease Relevance 0 Pain Relevance 0.16
The different effects of neurotensin depending on the order of administration may suggest long-lasting effects on the responsiveness of neurotensin receptors in this region after injection of high concentrations of the peptide.
Regulation (effects) of neurotensin
12) Confidence 0.45 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1319909 Disease Relevance 0 Pain Relevance 0.37
[Implication of the neuropeptides methionine enkephalin, neurotensin and somatostatin of the caudal trigeminal nucleus in the experimental migraine].
Regulation ([Implication) of neurotensin in nucleus associated with migraine, somatostatin, neuropeptide and enkephalin
13) Confidence 0.44 Published 2002 Journal Rev Neurol Section Title Doc Link 12080490 Disease Relevance 0.46 Pain Relevance 0.73
In this study we examine the effect of neurotensin on spinal cells and on the central pattern generator for locomotion in the lamprey spinal cord. 2.
Spec (examine) Regulation (effect) of neurotensin in spinal associated with spinal cord
14) Confidence 0.44 Published 1995 Journal J. Neurophysiol. Section Abstract Doc Link 7608774 Disease Relevance 0 Pain Relevance 0.26
Somatostatin exhibited competitive inhibition of tracer binding, while neuropeptides such as neurotensin, substance P, Leu-enkephalin, and vasoactive intestinal peptide were ineffective.
Regulation (ineffective) of neurotensin associated with neuropeptide, somatostatin, enkephalin and substance p
15) Confidence 0.44 Published 1984 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6149767 Disease Relevance 0 Pain Relevance 0.54
The role of neuropeptides in the regulation of adrenal vascular tone: effects of vasoactive intestinal polypeptide, substance P, neuropeptide Y, neurotensin, Met-enkephalin, and Leu-enkephalin on perfusion medium flow rate in the intact perfused rat adrenal.
Regulation (effects) of neurotensin associated with neuropeptide, enkephalin and substance p
16) Confidence 0.44 Published 1994 Journal Regul. Pept. Section Title Doc Link 7518603 Disease Relevance 0 Pain Relevance 0.73
Many stressors elicit changes in corticotrophin (CRH), enkephalin (ENK), and neurotensin (NT) mRNA levels within the medial parvocellular region of the paraventricular nucleus of the hypothalamus (mpPVN), and the pattern of changes in mRNA levels appears to depend on the physical characteristics of the stressor.
Regulation (changes) of neurotensin in medial associated with enkephalin
17) Confidence 0.44 Published 1999 Journal J. Neuroendocrinol. Section Abstract Doc Link 10048467 Disease Relevance 0.19 Pain Relevance 0.27
This study provides evidence that the mesostriatal DA system regulates CRH and neurotensin mRNA in the BSTov and CEA, suggesting that dopamine may be an important modulator of CRH and neurotensin function within these nuclei.
Regulation (modulator) of neurotensin in CEA associated with dopamine and amygdala
18) Confidence 0.44 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.70
The effects of superfused neurotensin and neurotensin receptor antagonists were measured under single-electrode current clamp.
Regulation (effects) of neurotensin associated with antagonist
19) Confidence 0.42 Published 1999 Journal Neuroscience Section Abstract Doc Link 10579568 Disease Relevance 0 Pain Relevance 0.05
The effects of superfused neurotensin and neurotensin receptor antagonists were measured under single-electrode current clamp.
Regulation (effects) of neurotensin associated with antagonist
20) Confidence 0.42 Published 1999 Journal Neuroscience Section Abstract Doc Link 10579568 Disease Relevance 0 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox