INT77142

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Context Info
Confidence 0.03
First Reported 1998
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.16
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG, IL4) extracellular region (IFNG, IL4)
Anatomy Link Frequency
T-helper cell 3
IFNG (Homo sapiens)
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 11 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
Dynorphin 3 99.80 Very High Very High Very High
Kappa opioid receptor 3 67.92 Quite High
Disease Link Frequency Relevance Heat
Stress 2 84.32 Quite High
Bacterial Infection 3 82.80 Quite High
Cancer 8 78.64 Quite High
Hematological Disease 6 76.24 Quite High
Virus Diseases 3 37.28 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 35.36 Quite Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of melatonin receptors enhances the release of T-helper cell type 1 (Th1) cytokines, such as gamma-interferon and interleukin-2, as well as of novel opioid cytokines which crossreact immunologically with both interleukin-4 and dynorphin B.
gamma-interferon Binding (crossreact) of interleukin-4 in T-helper cell associated with dynorphin, opioid and cytokine
1) Confidence 0.03 Published 1998 Journal J. Photochem. Photobiol. B, Biol. Section Abstract Doc Link 9718719 Disease Relevance 0.31 Pain Relevance 0.35
Activation of MLT receptors enhances the release of T-helper cell type 1 (Th1) cytokines, such as gamma-interferon and interleukin-2 (IL-2), as well as of novel opioid cytokines which crossreact immunologically with both interleukin-4 (IL-4) and dynorphin B.
gamma-interferon Binding (crossreact) of IL-4 in T-helper cell associated with dynorphin, opioid and cytokine
2) Confidence 0.01 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10810540 Disease Relevance 0.43 Pain Relevance 0.30
Activation of MLT receptors enhances the release of T-helper cell type 1 (Th1) cytokines, such as gamma-interferon and interleukin-2 (IL-2), as well as of novel opioid cytokines which crossreact immunologically with both interleukin-4 (IL-4) and dynorphin B.
gamma-interferon Binding (crossreact) of interleukin-4 in T-helper cell associated with dynorphin, opioid and cytokine
3) Confidence 0.01 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10810540 Disease Relevance 0.42 Pain Relevance 0.30

General Comments

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