INT77146

Context Info Confidence 0.36 First Reported 1998 Last Reported 2010 Negated 2 Speculated 1 Reported most in Body Documents 23 Total Number 24 Disease Relevance 13.69 Pain Relevance 5.39

extracellular space (IL4) extracellular region (IL4)

Anatomy Link Frequency T-helper cell 2 T cells 2 capillary 1 Th2 cells 1 mononuclear cell 1 IL4 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 370 100.00 chemokine 52 100.00 Dynorphin 2 99.80 Opioid 4 99.66 rheumatoid arthritis 274 99.60 Inflammation 264 99.36 Inflammatory response 19 84.16 cINOD 15 83.36 Central nervous system 7 81.36 headache 12 80.28

Disease Link Frequency Relevance Heat Infection 129 100.00 Cancer 117 100.00 Necrosis 11 100.00 Rheumatoid Arthritis 279 99.60 INFLAMMATION 292 99.36 Eczema 5 98.84 Immunization 9 98.68 Mantle-cell Lymphoma 33 98.18 Increased Venous Pressure Under Development 34 97.96 Asthma 315 97.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

, interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumour necrosis factor-alpha (TNF-?)

interleukin-4 Binding (interleukin-6) of associated with necrosis and cancer

1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766003 Disease Relevance 0.20 Pain Relevance 0.08

The inhibitory effect of ASA on IL-4 transcription was not mediated by decreased nuclear expression of the known salicylate target nuclear factor (NF)-kappaB and was accompanied by reduced binding of an inducible factor to an IL-4 promoter region upstream of, but not overlapping, the NF of activated T cells- and NF-kappaB-binding P1 element.

IL-4 Neg (not) Binding (binding) of in T cells

2) Confidence 0.33 Published 2001 Journal Blood Section Abstract Doc Link 11238116 Disease Relevance 0.17 Pain Relevance 0.30

IL-4 and other suppressive cytokines that can be produced by Th2 cells (e.g.

IL-4 Binding (e.g.) of in Th2 cells associated with cytokine

3) Confidence 0.30 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 1.28 Pain Relevance 0.64

Although we show that IL-7, and in particular the combination of IL-7 and IL-4, increased Th2 activity rather than Th1 activity of naive CD4+ T cells, this was only found under conditions where IFN-?

IL-4 Binding (combination) of in T cells

4) Confidence 0.30 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.54 Pain Relevance 0.22

The combination of IL-7 and IL-4 reduced IFN-?

IL-4 Binding (combination) of

5) Confidence 0.30 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.21 Pain Relevance 0.10

The purpose of this study was to evaluate the levels of nitric oxide (NO), IL-4, TGF-beta, tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) in chronic periapical lesions and to determine their possible association with clinical and radiographic parameters.

IL-4 Binding (association) of associated with necrosis and cancer

6) Confidence 0.27 Published 2010 Journal J. Oral Pathol. Med. Section Abstract Doc Link 20102461 Disease Relevance 0.35 Pain Relevance 0.04

The scatter plot of log signal intensities from the HV pool (horizontal) and patient TA8 (vertical) show that the signal intensities of IL-4 and IL-10 are considerably lower than that of DEFA3.

IL-4 Binding (intensities) of

7) Confidence 0.20 Published 2010 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2993541 Disease Relevance 0.16 Pain Relevance 0

, IL-4, and IL-2 upon rechallenge in vitro with allergen [165].

IL-4 Binding (rechallenge) of

8) Confidence 0.16 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.65 Pain Relevance 0.18

Levels tended to normalize to baseline values within 3–4 weeks of infection in all animals, with IL2, IL4, IL12p40, IFN?

IL4 Binding (tended) of associated with infection

9) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2787245 Disease Relevance 1.10 Pain Relevance 0.21

At two weeks after the initial vaccination (on day 15), the 5 immunization sites were punch biopsied and evaluated to determine the dose of IL-4 associated with the most intense mononuclear cell infiltrate.

IL-4 Binding (associated) of in mononuclear cell associated with immunization

10) Confidence 0.14 Published 2007 Journal J Transl Med Section Body Doc Link PMC2254376 Disease Relevance 0.86 Pain Relevance 0.08

Interestingly, IL-4+TGF-?

IL-4 Binding (Interestingly) of

11) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.25 Pain Relevance 0.11

alone or in combination with either IL-4 or TGF-?

IL-4 Binding (combination) of

12) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.14 Pain Relevance 0.14

We found that IL-4+TGF-?

IL-4 Binding (found) of

13) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.10 Pain Relevance 0.08

Accordingly, the IL-4 : IFN-?

IL-4 Binding (Accordingly) of

14) Confidence 0.09 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.98 Pain Relevance 0.48

Activation of melatonin receptors enhances the release of T-helper cell type 1 (Th1) cytokines, such as gamma-interferon and interleukin-2, as well as of novel opioid cytokines which crossreact immunologically with both interleukin-4 and dynorphin B.

interleukin-4 Binding (crossreact) of in T-helper cell associated with dynorphin, opioid and cytokine

15) Confidence 0.09 Published 1998 Journal J. Photochem. Photobiol. B, Biol. Section Abstract Doc Link 9718719 Disease Relevance 0.31 Pain Relevance 0.35

These include the release of IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor-alfa (TNF-alfa), platelet-activating factor, endorphins, nitric oxide, reactive oxygen species, tissue factor, macrophage migration inhibitory factor, and chemokines, which lead to a variety of immune system responses including vasodilatation, enhanced expression of adhesion molecules, increased capillary permeability, increased clot formation, and decreased fibrinolysis.

IL-4 Binding (lead) of in capillary associated with chemokine, necrosis, cancer, increased venous pressure under development and adhesions

16) Confidence 0.07 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012437 Disease Relevance 1.09 Pain Relevance 0.23

Some of the patients suffered also from atopic dermatitis (AD) and were exposed to cat and/or other pet allergens, associated with an increased IL-4 and decreased IFN-gamma production.

IL-4 Binding (associated) of associated with eczema

17) Confidence 0.05 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 1.50 Pain Relevance 0.62

[42], anti-CD3/CD28 antibodies or antigen specific stimulation [43,44], IL-4/IL-13 [45,46], and thrombospondin-CD47 interaction [46].

IL-4 Binding (interaction) of

18) Confidence 0.04 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.18 Pain Relevance 0.09

Activation of MLT receptors enhances the release of T-helper cell cytokines, such as gamma-interferon and interleukin-2 (IL-2), as well as activation of novel opioid cytokines which crossreact immunologically with both interleukin-4 and dynorphin B.

interleukin-4 Binding (crossreact) of in T-helper cell associated with dynorphin, opioid and cytokine

19) Confidence 0.04 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10721059 Disease Relevance 0.59 Pain Relevance 0.35

, are more likely to be associated with allograft rejection than Th2-type cytokines, such as IL-4, IL?

IL-4 Spec (likely) Binding (associated) of associated with cytokine

20) Confidence 0.04 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2807615 Disease Relevance 0.44 Pain Relevance 0.25

General Comments

This test has worked.