INT77148

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Context Info
Confidence 0.73
First Reported 1998
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 4.08
Pain Relevance 4.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcna1) transmembrane transport (Kcna1)
Anatomy Link Frequency
neurons 3
brain 2
hippocampus 2
sensory neurons 1
uterus 1
Kcna1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 70 100.00 Very High Very High Very High
Hippocampus 54 99.98 Very High Very High Very High
Hyperalgesia 3 99.82 Very High Very High Very High
tetrodotoxin 13 99.70 Very High Very High Very High
Spinal cord 3 98.64 Very High Very High Very High
Morphine 2 98.24 Very High Very High Very High
antinociception 2 97.56 Very High Very High Very High
Pain 1 95.28 Very High Very High Very High
Neuronal excitability 42 95.20 Very High Very High Very High
depression 9 94.00 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 245 99.88 Very High Very High Very High
Hyperalgesia 3 99.82 Very High Very High Very High
Embryonic Lethality 5 99.60 Very High Very High Very High
Lifespan 20 98.82 Very High Very High Very High
Convulsion 168 98.36 Very High Very High Very High
Sleep Disorders 70 96.00 Very High Very High Very High
Pain 1 95.28 Very High Very High Very High
Depression 9 94.00 High High
Syndrome 5 77.08 Quite High
Stress 5 32.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Impairing secretion by clostridial neurotoxins or blocking activity by tetrodotoxin inhibited the expression of Kv1.1, Kv1.2, and Kv1.4, whereas the other Kv1 channels still appeared.
Gene_expression (expression) of Kv1 associated with tetrodotoxin
1) Confidence 0.73 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684888 Disease Relevance 0.09 Pain Relevance 0.37
The ontogenetic regulation and the activity-dependent expression of Kv1.1, Kv1.2, and Kv1.4 indicate that neuronal activity plays a crucial role for the development of the mature Kv channel pattern in hippocampal neurons.
Gene_expression (expression) of Kv1 in neurons
2) Confidence 0.73 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684888 Disease Relevance 0.09 Pain Relevance 0.24
Impairing secretion by clostridial neurotoxins or blocking activity by tetrodotoxin inhibited the expression of Kv1.1, Kv1.2, and Kv1.4, whereas the other Kv1 channels still appeared.
Gene_expression (expression) of Kv1 associated with tetrodotoxin
3) Confidence 0.73 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684888 Disease Relevance 0.09 Pain Relevance 0.37
Impairing secretion by clostridial neurotoxins or blocking activity by tetrodotoxin inhibited the expression of Kv1.1, Kv1.2, and Kv1.4, whereas the other Kv1 channels still appeared.
Gene_expression (expression) of Kv1 associated with tetrodotoxin
4) Confidence 0.73 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684888 Disease Relevance 0.09 Pain Relevance 0.37
The ontogenetic regulation and the activity-dependent expression of Kv1.1, Kv1.2, and Kv1.4 indicate that neuronal activity plays a crucial role for the development of the mature Kv channel pattern in hippocampal neurons.
Gene_expression (expression) of Kv1 in neurons
5) Confidence 0.73 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684888 Disease Relevance 0.09 Pain Relevance 0.24
To learn more about distribution, development, and activity-dependent regulation of Kv channel subunit expression in the rodent hippocampus, we studied the protein expression of members of the Kv1 subfamily in mouse hippocampus in situ and in primary cultures.
Gene_expression (expression) of Kv1 in hippocampus associated with hippocampus
6) Confidence 0.73 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684888 Disease Relevance 0 Pain Relevance 0.21
The ontogenetic regulation and the activity-dependent expression of Kv1.1, Kv1.2, and Kv1.4 indicate that neuronal activity plays a crucial role for the development of the mature Kv channel pattern in hippocampal neurons.
Gene_expression (expression) of Kv1 in neurons
7) Confidence 0.73 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684888 Disease Relevance 0.09 Pain Relevance 0.24
The current study in Kcna2 KO mice suggests, however, that such block must be almost complete for NREM sleep to be affected, because HZ mice, which express approximately half of the wild-type amount of Kv1.2, slept normally.
Gene_expression (express) of Kv1 associated with targeted disruption
8) Confidence 0.65 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0.31 Pain Relevance 0.08
In adult hippocampus, Kv1 (1-6) channel alpha-subunits were present, whereas at postnatal day 2, none of these proteins could be detected in CA1-CA3 and dentate gyrus.
Gene_expression (present) of Kv1 in dentate gyrus associated with hippocampus
9) Confidence 0.64 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684888 Disease Relevance 0 Pain Relevance 0.21
Seizures and a reduced lifespan have also been described in Kcna1 null mice, in which the expression of the Kv1.1 subunit is abolished [18], as well as in Kcnab2 null mice [19], lacking the modulatory subunit beta 2, which co-distributes extensively with Kv1.1 and Kv1.2 in the adult rat brain [11].
Gene_expression (expression) of Kv1 in brain associated with convulsion and lifespan
10) Confidence 0.58 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0.81 Pain Relevance 0.05
Specifically, Kv1.2 is prominently and homogenously expressed in the rat thalamocortical system [12-14], which is important for the generation of sleep rhythms [15].
Gene_expression (expressed) of Kv1
11) Confidence 0.58 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0.38 Pain Relevance 0.21
In this study we confirmed that Kcna2 null mice, in which the expression of the voltage-dependent potassium channel alpha subunit Kv1.2 is completely abolished, die within the first 3–4 weeks because of an episode of generalized seizures [17].
Gene_expression (expression) of Kv1 associated with convulsion and potassium channel
12) Confidence 0.58 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0.58 Pain Relevance 0.05
KO mice express no Kv1.2 mRNA or protein, while HZ mice express approximately half of the wild-type amount [17].
Neg (no) Gene_expression (express) of Kv1 associated with targeted disruption
13) Confidence 0.58 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 1.02 Pain Relevance 0.08
Kv1.1 channels are expressed in many regions of the brain and spinal cord [Monaghan, M.
Gene_expression (expressed) of Kv1 in spinal cord associated with spinal cord
14) Confidence 0.50 Published 2008 Journal Bioorg. Med. Chem. Section Abstract Doc Link 18226531 Disease Relevance 0 Pain Relevance 0.11
In the hippocampus Kv1.1 is co-expressed with Kvbeta1 (and other beta subunits), which converts Kv1.1 into a transient, fast inactivating current, reducing its ability to hyperpolarize the cell and thus increasing neuronal excitability.
Gene_expression (co-expressed) of Kv1 in hippocampus associated with neuronal excitability and hippocampus
15) Confidence 0.50 Published 2008 Journal Bioorg. Med. Chem. Section Abstract Doc Link 18226531 Disease Relevance 0.05 Pain Relevance 0.18
Expression of Kv1 potassium channels in mouse hippocampal primary cultures: development and activity-dependent regulation.
Gene_expression (Expression) of Kv1 associated with potassium channel
16) Confidence 0.49 Published 2000 Journal J. Neurosci. Section Title Doc Link 10684888 Disease Relevance 0 Pain Relevance 0.20
Hyperalgesia in mice lacking the Kv1.1 potassium channel gene.
Neg (lacking) Gene_expression (lacking) of Kv1 associated with hyperalgesia and potassium channel
17) Confidence 0.18 Published 1998 Journal Neurosci. Lett. Section Title Doc Link 9718989 Disease Relevance 0.29 Pain Relevance 0.75
Kv1.1 channels are expressed in many regions of the brain and spinal cord [Monaghan, M.
Gene_expression (expressed) of Kv1 in brain associated with spinal cord
18) Confidence 0.17 Published 2008 Journal Bioorg. Med. Chem. Section Abstract Doc Link 18226531 Disease Relevance 0 Pain Relevance 0.11
subunits shown in Figure 5 (e.g. there appears to be a little more Kv1.1 expression in term-pregnant myometrium than in nonpregnant tissues), we are unwilling at present to ascribe any significance to these differences other than the profound reduction in Kv4.3 expression which occurs near the end of gestation (Figures 5 and 7), a finding which is consistent with those of Song et al. [19] who found a reduction in Kv4.3 mRNA and protein expression in pregnant rat uterus which appears to be dependent upon estrogen.
Gene_expression (expression) of Kv1 in uterus
19) Confidence 0.07 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2186335 Disease Relevance 0 Pain Relevance 0.04
While there was variability in the level of expression of Kv4.3 at different stages of pregnancy, expression of Kv1.4 was found to be highly consistent throughout the stages of pregnancy and from experiment to experiment (Figure 7.b).
Gene_expression (expression) of Kv1
20) Confidence 0.06 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2186335 Disease Relevance 0 Pain Relevance 0

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