INT7715

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Context Info
Confidence 0.62
First Reported 1990
Last Reported 2011
Negated 9
Speculated 9
Reported most in Abstract
Documents 35
Total Number 44
Disease Relevance 10.79
Pain Relevance 22.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
signal transducer activity (Drd2)
Anatomy Link Frequency
striatum 3
brain 3
output neurons 1
Spinal cord 1
caudate putamen 1
Drd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 1075 100.00 Very High Very High Very High
antagonist 99 100.00 Very High Very High Very High
midbrain 85 100.00 Very High Very High Very High
agonist 83 100.00 Very High Very High Very High
dopamine receptor 69 100.00 Very High Very High Very High
Enkephalin 42 100.00 Very High Very High Very High
Morphine 41 100.00 Very High Very High Very High
substance P 25 100.00 Very High Very High Very High
opioid receptor 12 100.00 Very High Very High Very High
anesthesia 11 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 7 100.00 Very High Very High Very High
Nociception 6 100.00 Very High Very High Very High
Vomiting 24 99.52 Very High Very High Very High
Overactive Bladder 6 99.48 Very High Very High Very High
Disease 69 99.22 Very High Very High Very High
Abnormal Reflex 2 99.12 Very High Very High Very High
Targeted Disruption 252 98.88 Very High Very High Very High
Headache 1 97.98 Very High Very High Very High
Morning Sickness 1 97.72 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 529 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was suggested that the developmental regulation of D1R and D2R mRNAs would result from intrinsic genetic programs, while the dopaminergic innervation would control the D1R and D2R protein synthesis (Jung and Bennett, 1996).
Regulation (regulation) of D2R
1) Confidence 0.62 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.11
In the last two decades, many biological functions of iron have been identified, in particular its role in many enzymatic processes, its effect on dopamine D2 receptor function, its interaction with other neurotransmitters (gamma-aminobutyric acid, serotonin, opiate-peptides), and its catalytic role in the nonenzymatic mechanisms for oxidation, hydroxylation, and peroxidation reactions.
Regulation (effect) of dopamine D2 receptor associated with neurotransmitter, dopamine, opiate and serotonin
2) Confidence 0.60 Published 1993 Journal J Neuropsychiatry Clin Neurosci Section Abstract Doc Link 8094018 Disease Relevance 0.38 Pain Relevance 0.24
We detected no sex chromosome effect on D2 receptor mRNA.
Neg (no) Regulation (effect) of D2 receptor mRNA
3) Confidence 0.58 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19250439 Disease Relevance 0 Pain Relevance 0.14
The effects of dynorphin A(1-13) on the D1 dopamine agonist SK&F 38393- and the D2 dopamine agonist RU 24213-induced behavioral alterations in the mouse were determined by using multidimensional behavioral analyses based upon a capacitance system.
Regulation (alterations) of D2 dopamine associated with dopamine, dynorphin and agonist
4) Confidence 0.54 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1355296 Disease Relevance 0 Pain Relevance 0.63
The 5-HT1C/2 antagonist, ritanserin, the 5-HT3 antagonist, ondansetron, the dopamine D2 receptor antagonist, raclopride, and the alpha 1-adrenoceptor antagonist, prazosin, were also ineffective in modifying the antinociception evoked by 5-HT1A agonists and partial agonists in the hot-plate test.
Regulation (ineffective) of dopamine D2 receptor associated with antinociception, dopamine, antagonist and agonist
5) Confidence 0.45 Published 1994 Journal Pain Section Abstract Doc Link 7970839 Disease Relevance 0.16 Pain Relevance 1.70
The generation of BAC transgenic mice expressing DARPP-32 with different tags under the control of drd1a and drd2 promoters allowed the analysis of DARPP-32 phosphorylation selectively in the two populations of striatal output neurons in vivo (Bateup et al., 2008) (Figure 1).
Regulation (control) of drd2 in output neurons associated with targeted disruption
6) Confidence 0.45 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.10 Pain Relevance 0.07
To determine the role of the D2 dopamine receptor subtype in mediating opiate motivation, we examined the behaviour of N5 congenic D2 receptor knockout mice and their wild-type siblings in opiate-naive and opiate-dependent and withdrawn place conditioning paradigms.
Spec (determine) Regulation (role) of D2 dopamine receptor associated with targeted disruption, dopamine receptor and opiate
7) Confidence 0.45 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11264672 Disease Relevance 0.18 Pain Relevance 1.14
However, our previous study did not determine whether all DARPP-32-positive cells expressed EGFP under the control of either drd1a or drd2 promoter.
Spec (whether) Regulation (control) of drd2
8) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.29 Pain Relevance 0
The effects of anesthesia on dopamine D2 receptor binding in the rhesus monkey brain were examined using positron emission tomography.
Regulation (effects) of dopamine D2 receptor in brain associated with dopamine, anesthesia and positron emission tomography
9) Confidence 0.44 Published 1995 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 8962684 Disease Relevance 0 Pain Relevance 0.47
Signalling via rat dopamine D2-receptors expressed in mouse fibroblasts is not influenced by compounds binding to the sigma sites of these cells.
Neg (not) Regulation (influenced) of D2-receptor in fibroblasts associated with fortral and dopamine
10) Confidence 0.44 Published 1993 Journal Cell. Signal. Section Title Doc Link 8130078 Disease Relevance 0 Pain Relevance 0.45
Spinal cord excitation was induced in mice by morphine and the effects of dopamine D1 and D2 receptor antagonists on the Straub tail reaction were investigated.
Regulation (effects) of D2 receptor in Spinal cord associated with dopamine, antagonist, morphine and spinal cord
11) Confidence 0.41 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2150374 Disease Relevance 0 Pain Relevance 0.65
In addition, the level of expression of enkephalin and substance P, which were altered in D2R-/-, were also reestablished to normal levels after A2AR antagonist treatment.
Regulation (altered) of D2R associated with antagonist, enkephalin and substance p
12) Confidence 0.39 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10908627 Disease Relevance 0.38 Pain Relevance 0.61
Studies suggest that D2 receptors are
   responsible for mediating the self-reinforcing effect of drugs, while the D1 receptors act in a
   permissive fashion to facilitate the response. 
Regulation (responsible) of D2
13) Confidence 0.39 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0.06 Pain Relevance 0.50
For example, a study in humans using PET imaging showed no changes in
   dopamine D2 receptor availability in the caudate putamen after treadmill running (submax);
   however, the subjects used in this study were already persons with a history of regular exercise
    175. 
Neg (no) Regulation (changes) of dopamine D2 receptor in caudate putamen associated with dopamine, positron emission tomography and imagery
14) Confidence 0.39 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0.11 Pain Relevance 0.47
In contrast striatal mRNA expression levels for DRD2 and PPE did not differ between control and mutant animals (Fig. 5A and B).
Neg (not) Regulation (differ) of DRD2
15) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.62
The reactivation effects of the delta-opioid receptor blockade and D2 dopamine receptor activation on the detention-induced memory deficit in mice were investigated, in order to study possible interactions between opioid and dopamine systems in memory retrieval.
Spec (investigated) Regulation (effects) of D2 dopamine receptor associated with dopamine, dopamine receptor, opioid receptor and opioid
16) Confidence 0.36 Published 1996 Journal Behav. Brain Res. Section Abstract Doc Link 8883813 Disease Relevance 0 Pain Relevance 0.42
The consequences of increased extracellular dopamine is demonstrated in the DAT-KO mouse which loses the normal inhibitory effect of DRD2 on dopamine neuron firing rate in the VTA and substantia nigra, as well as dopamine release-regulating DRD2 function in the striatum [190].
Regulation (regulating) of DRD2 in striatum associated with dopamine, substantia nigra and midbrain
17) Confidence 0.31 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.25 Pain Relevance 0.99
In vitro DRD2-mediated inhibition of dopamine release was greater in SHR caudate-putamen and nucleus accumbens than WKY, while DRD2 function was unchanged in prefrontal cortex of SHR [77].
Neg (unchanged) Regulation (unchanged) of DRD2 in prefrontal associated with nucleus accumbens and dopamine
18) Confidence 0.31 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.12 Pain Relevance 0.85
To elucidate the specific role of the dopamine D2 receptor (D2R) in the pituitary and brain, we generated D2R deficient (D2R mutant) mice using the gene targeting method.
Regulation (role) of dopamine D2 receptor in pituitary associated with dopamine
19) Confidence 0.27 Published 1996 Journal Genes Cells Section Abstract Doc Link 9140068 Disease Relevance 0 Pain Relevance 0.09
Six C57Bl/6J–Swiss Webster hybrid transgenic mice carrying BAC that express enhanced green fluorescent protein (BAC-EGFP) under the control of D1R promoter (drd1a-EGFP) or D2R promoter (drd2-EGFP) were used for characterization of striatonigral and striatopallidal specificity of labeling.
Regulation (control) of D2R associated with targeted disruption
20) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.32 Pain Relevance 0

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