INT77152

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Context Info
Confidence 0.26
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.12
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
spinal cord 2
H2-K1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6 100.00 Very High Very High Very High
cytokine 4 100.00 Very High Very High Very High
bradykinin 2 99.92 Very High Very High Very High
Spinal cord 24 97.86 Very High Very High Very High
Pain 2 96.56 Very High Very High Very High
Neuropathic pain 2 87.52 High High
gABA 4 69.04 Quite High
Peripheral nerve injury 2 67.60 Quite High
Sciatic nerve 22 39.08 Quite Low
dorsal root ganglion 2 7.44 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 100.00 Very High Very High Very High
Hypersensitivity 2 98.20 Very High Very High Very High
Pain 2 96.56 Very High Very High Very High
Targeted Disruption 20 88.80 High High
Neuropathic Pain 2 87.52 High High
Pox Virus Infection 1 85.60 High High
Parasitic Infection 2 84.16 Quite High
Wallerian Degeneration 2 81.04 Quite High
Nervous System Injury 2 66.72 Quite High
Sprains And Strains 26 65.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taking into account the profound acute changes in spinal cord circuits following a peripheral lesion, it is possible that NO may be involved in signaling pathways that induce MHC I upregulation by neurons and glia.
Positive_regulation (induce) of Positive_regulation (upregulation) of MHC I in spinal cord associated with spinal cord
1) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.54 Pain Relevance 0.31
Regardless of the initial stimulus, a common response leading to NO synthesis is the upregulation of inflammatory cytokines such as interferon gamma, a potent MHC I inducer.
Positive_regulation (upregulation) of Positive_regulation (upregulation) of MHC I associated with inflammation and cytokine
2) Confidence 0.19 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.30 Pain Relevance 0.18
Bradykinin is generated by activation of the plasma kallikrein-kinin (K-K) cascade and contributes to the symptoms of allergic reactions and the perception of pain.
Positive_regulation (generated) of Positive_regulation (activation) of K-K in plasma associated with pain, hypersensitivity and bradykinin
3) Confidence 0.01 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9719471 Disease Relevance 0.28 Pain Relevance 0.15

General Comments

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