INT7716

Context Info Confidence 0.68 First Reported 1987 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 9 Total Number 9 Disease Relevance 0.80 Pain Relevance 4.69

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a) signal transducer activity (Adra2a)

Anatomy Link Frequency brain 2 nucleus 2 Adra2a (Mus musculus)

Pain Link Frequency Relevance Heat MU agonist 4 99.92 alcohol 6 99.76 Endep 7 99.62 depression 1 99.52 adenocard 6 99.38 Analgesic 2 99.20 Pain threshold 1 99.10 Pain 1 98.94 Clonidine 9 98.90 tricyclic antidepressant 2 98.08

Disease Link Frequency Relevance Heat Targeted Disruption 1 100.00 Respiratory Failure 1 99.52 Pain 1 99.10 Sleep Disorders 2 97.44 Aids-related Complex 1 94.16 Central Sleep Apnea 1 88.36 Stupor 1 75.00 Nociception 1 70.08 Disease 1 40.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results suggest that alpha2-AR agonist-induced ventilatory excitation (tachypnea) requires the activation of alpha2A-ARs whereas clonidine-induced ventilatory depression (arrhythmic breathing) requires the activation of an alternate alpha2-AR subtype (presumably alpha2C-ARs).

Positive_regulation (requires) of Positive_regulation (activation) of alpha2-AR associated with depression, respiratory failure, agonist and clonidine

1) Confidence 0.68 Published 2001 Journal Respir Physiol Section Abstract Doc Link 11282385 Disease Relevance 0.19 Pain Relevance 0.63

These data indicate that the enhancement of the pain threshold produced by amitriptyline and imipramine is mediated by activation of alpha2A-adrenoceptors.

Positive_regulation (mediated) of Positive_regulation (activation) of alpha2A associated with pain threshold and endep

2) Confidence 0.49 Published 2000 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10877531 Disease Relevance 0.19 Pain Relevance 0.94

The analgesic efficacy of partial opioid agonists is increased in mice with targeted inactivation of the alpha2A-adrenoceptor gene.

Positive_regulation (increased) of Positive_regulation (inactivation) of alpha2A associated with pain, mu agonist and analgesic

3) Confidence 0.49 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16325800 Disease Relevance 0 Pain Relevance 1.40

Norepinephrine transporter knockout-induced up-regulation of brain alpha2A/C-adrenergic receptors.

Positive_regulation (knockout-induced) of Positive_regulation (up-regulation) of alpha2A in brain associated with targeted disruption

4) Confidence 0.49 Published 2006 Journal J. Neurochem. Section Title Doc Link 16417582 Disease Relevance 0.10 Pain Relevance 0.32

Stimulation of alpha 2-adrenergic receptors in nucleus tractus solitarius is required for the baroreceptor reflex.

Positive_regulation (required) of Positive_regulation (Stimulation) of 2-adrenergic in nucleus

5) Confidence 0.18 Published 1992 Journal Brain Res. Section Title Doc Link 1355387 Disease Relevance 0 Pain Relevance 0.17

These results indicate that tonic stimulation of alpha 2-adrenergic receptors in the NTS is required for baroreceptor reflex function.

Positive_regulation (required) of Positive_regulation (stimulation) of 2-adrenergic

6) Confidence 0.18 Published 1992 Journal Brain Res. Section Abstract Doc Link 1355387 Disease Relevance 0 Pain Relevance 0.17

These results demonstrate that induction of loss of righting reflex by combined diazepam and alcohol is closely dependent on the activation of the alpha2-GABAA receptors by the benzodiazepine whereas precipitation of sedation involves GABAA receptors other than the alpha2-GABAA receptors.

Positive_regulation (dependent) of Positive_regulation (activation) of alpha2 associated with sleep disorders and alcohol

7) Confidence 0.13 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622161 Disease Relevance 0.25 Pain Relevance 0.21

We conclude that the potentiation by epinephrine of adenosine-induced glucagon secretion is mediated by alpha 2-adrenergic receptor activation.

Positive_regulation (mediated) of Positive_regulation (activation) of alpha 2-adrenergic associated with adenocard

8) Confidence 0.07 Published 1987 Journal Endocrinology Section Abstract Doc Link 3036483 Disease Relevance 0 Pain Relevance 0.50

In these cells, the activation of either mu or alpha2A receptor leads to a significant increase in the level of immunoprecipitable mu-alpha2A complexes, whereas activation of both receptors leads to a significant decrease.

Positive_regulation (increase) of Positive_regulation (activation) of alpha2A receptor

9) Confidence 0.03 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14645661 Disease Relevance 0.07 Pain Relevance 0.34

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