INT77215

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Context Info
Confidence 0.77
First Reported 1998
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ADORA2A) enzyme binding (ADORA2A) cell-cell signaling (ADORA2A)
signal transducer activity (ADORA2A)
Anatomy Link Frequency
nucleus 1
ADORA2A (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 11 100.00 Very High Very High Very High
opiate 1 100.00 Very High Very High Very High
Morphine 3 97.60 Very High Very High Very High
Nucleus accumbens 2 94.80 High High
Dopamine 3 69.20 Quite High
substance P 1 58.56 Quite High
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Double in situ hybridization demonstrated an extensive colocalization of adenosine A2A receptor and preproenkephalin A mRNAs in approximately 50% of the medium-sized spiny neurons of the monkey nucleus caudatus, putamen, and nucleus accumbens.
Localization (colocalization) of adenosine A2A receptor in nucleus associated with nucleus accumbens and adenocard
1) Confidence 0.77 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9721905 Disease Relevance 0 Pain Relevance 0.54
It has been demonstrated that a specific mu-opiate-receptor subtype, mu3, mediates these downregulatory effects through release of NO.
Localization (release) of mu-opiate-receptor subtype associated with opiate
2) Confidence 0.13 Published 2000 Journal Trends Neurosci. Section Abstract Doc Link 10941194 Disease Relevance 0 Pain Relevance 0.36

General Comments

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