INT77223

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Context Info
Confidence 0.03
First Reported 1998
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.32
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Eif4ebp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 5 98.32 Very High Very High Very High
agonist 9 91.84 High High
Enkephalin 2 83.16 Quite High
MU agonist 2 73.24 Quite High
Morphine 2 69.88 Quite High
Analgesic 1 61.48 Quite High
Intracerebroventricular 15 40.12 Quite Low
corticosteroid 37 5.00 Very Low Very Low Very Low
cytokine 23 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 43 94.64 High High
Obesity 118 89.68 High High
Apoptosis 3 88.04 High High
Neointima 12 79.36 Quite High
Weight Gain 1 74.56 Quite High
Insulin Resistance 2 70.88 Quite High
Diabetes Mellitus 14 66.00 Quite High
Injury 18 53.68 Quite High
Hyperplasia 5 41.68 Quite Low
Organ Transplantation 5 33.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study demonstrated that the inhibition of the activity of the mTOR-P70S6K pathway may be an important mechanism involved in modulating the effects of various downstream signaling factors, such as the 4E-BP1 and CDK/CK complexes.
Regulation (effects) of 4E-BP1
1) Confidence 0.03 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.53 Pain Relevance 0.05
AMPK, ACC, p70S6K and 4EBP1 protein levels were not different between the groups (Figures 5b–e, lower panels).


Neg (not) Regulation (different) of 4EBP1
2) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.09 Pain Relevance 0
AMPK, ACC, p70S6K and 4EBP1 protein levels were not different between the groups (Figures 6c–f, lower panels).


Neg (not) Regulation (different) of 4EBP1
3) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.61 Pain Relevance 0
AMPK, ACC, p70S6K and 4EBP1 protein levels were not different between the groups (Figures 3b–e, lower panels).
Neg (not) Regulation (different) of 4EBP1
4) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
DAMGO also stimulates the phosphorylation of two other downstream effectors of PI3K, the p70 S6 kinase and the repressors of mRNA translation, 4E-BP1 and 4E-BP2.
Regulation (effectors) of 4E-BP1
5) Confidence 0.00 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9722592 Disease Relevance 0.09 Pain Relevance 0.65
TOR and possibly the phosphatase PP2A control the phosphorylation of proteins that regulate the translation of mRNA's encoding regulators of the cell cycle such as translation inhibitor 4E-BP1, eukaryotic translation initiator protein 4G1, p70S6kinase, (which in turn phosphorylates 40S ribosomal protein S6) and cyclin-dependent kinases [39].
Regulation (regulators) of 4E-BP1
6) Confidence 0.00 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0 Pain Relevance 0

General Comments

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