INT77224

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Context Info
Confidence 0.05
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 0.70
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Anatomy Link Frequency
hypothalamus 4
muscle 2
Eif4ebp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 10 95.60 Very High Very High Very High
Enkephalin 4 74.00 Quite High
agonist 6 72.52 Quite High
MU agonist 4 64.08 Quite High
Morphine 4 60.72 Quite High
Analgesic 2 52.32 Quite High
Intracerebroventricular 20 7.32 Low Low
cytokine 13 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
nalbuphine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 156 80.96 Quite High
Apoptosis 2 78.88 Quite High
Appetite Loss 56 71.80 Quite High
Body Weight 16 5.00 Very Low Very Low Very Low
Heart Rate Under Development 15 5.00 Very Low Very Low Very Low
Sepsis 9 5.00 Very Low Very Low Very Low
Myocardial Infarction 6 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Coronary Heart Disease 3 5.00 Very Low Very Low Very Low
Muscular Atrophy 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
0.097), and moreover, elements examined downstream of AKT (phosphorylation levels of p70 S6K and 4E-BP1) were unchanged by the LPS treatment protocol described here.
Negative_regulation (levels) of Phosphorylation (phosphorylation) of 4E-BP1
1) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
1) to be sufficient to reduce muscle 4E-BP1 phosphorylation after 24 h.
Negative_regulation (reduce) of Phosphorylation (phosphorylation) of 4E-BP1 in muscle
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
Protein and phosphorylation levels of AKT, p70 S6K and 4E-BP1
Negative_regulation (levels) of Phosphorylation (phosphorylation) of 4E-BP1
3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
We also observed that the increased phosphorylations of p70S6K and 4EBP1, induced by exercise, were also reversed by antiĀ–IL-6 infusion (Figures 6e and f).
Negative_regulation (reversed) of Phosphorylation (phosphorylations) of 4EBP1
4) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.55 Pain Relevance 0
6 M) to rats pretreated with AICAR reduced both p70S6K and 4EBP1 phosphorylation levels in the hypothalamus.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of 4EBP1 in hypothalamus
5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
Exercised animals pretreated with Rapamycin also reduced hypothalamic p70S6K and 4EBP1 phosphorylation (Figures 8d and e).
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of 4EBP1
6) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
AICAR reduced p70S6K and 4EBP1 threonine phosphorylation levels in the hypothalamus of control and exercised rats.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of 4EBP1 in hypothalamus
7) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03
Phosphorylation of p70 S6 kinase and 4E-BP1 is also repressed by PI3K inhibitors as well as by rapamycin, the selective inhibitor of FRAP/mTOR.
Negative_regulation (repressed) of Phosphorylation (Phosphorylation) of 4E-BP1
8) Confidence 0.00 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9722592 Disease Relevance 0.08 Pain Relevance 0.59
Consistent with these findings, DAMGO-stimulated phosphorylation of 4E-BP1 impairs its ability to bind the translation initiation factor eIF-4E.
Negative_regulation (impairs) of Phosphorylation (phosphorylation) of 4E-BP1
9) Confidence 0.00 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9722592 Disease Relevance 0.07 Pain Relevance 0.42

General Comments

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