INT77226

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Context Info
Confidence 0.09
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 36
Total Number 36
Disease Relevance 6.39
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Anatomy Link Frequency
hypothalamus 7
adipocytes 2
myocardium 1
muscle 1
Eif4ebp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 5 98.58 Very High Very High Very High
agonist 54 98.32 Very High Very High Very High
opioid receptor 15 98.32 Very High Very High Very High
Potency 5 94.00 High High
Intracerebroventricular 90 88.08 High High
Enkephalin 6 84.76 Quite High
Inflammation 25 79.28 Quite High
MU agonist 6 74.84 Quite High
Morphine 6 71.48 Quite High
anesthesia 41 69.80 Quite High
Disease Link Frequency Relevance Heat
Obesity 723 99.04 Very High Very High Very High
Hyperplasia 21 98.62 Very High Very High Very High
Hyperinsulinism 5 97.72 Very High Very High Very High
Apoptosis 5 89.64 High High
Hyperglycemia 11 88.76 High High
Diabetes Mellitus 42 88.04 High High
Appetite Loss 253 85.44 High High
Cardiovascular Disease 10 80.84 Quite High
INFLAMMATION 25 79.28 Quite High
Insulin Resistance 10 74.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1) to be sufficient to reduce muscle 4E-BP1 phosphorylation after 24 h.
Phosphorylation (phosphorylation) of 4E-BP1 in muscle
1) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
0.097), and moreover, elements examined downstream of AKT (phosphorylation levels of p70 S6K and 4E-BP1) were unchanged by the LPS treatment protocol described here.
Phosphorylation (phosphorylation) of 4E-BP1
2) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
0.092) towards reduced phosphorylation of AKT residue Ser473 was detected (Fig. 4B). 24 h LPS infusion had no effect on the protein level or phosphorylation state of residues Thr421 and Ser424 of p70 S6K (Fig. 4C & 4D), nor on the phosphorylation state of Thr37 and Thr46 of 4E-BP1 (Fig. 4E), where both p70 S6K and 4E-BP1 are located downstream of AKT.
Phosphorylation (phosphorylation) of 4E-BP1
3) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0.03
Protein and phosphorylation levels of AKT, p70 S6K and 4E-BP1
Phosphorylation (phosphorylation) of 4E-BP1
4) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
It had been demonstrated that the sequence of events between the activation of Akt and increased phosphorylation of 4E-BP1 involves the activation of mTOR signaling.
Phosphorylation (phosphorylation) of 4E-BP1
5) Confidence 0.06 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.05 Pain Relevance 0.05
-LA increased p70S6K and 4EBP1 threonine phosphorylation of 19% and 11%, respectively (Figures 4d and e). ?
Phosphorylation (phosphorylation) of 4EBP1
6) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.05 Pain Relevance 0.07
We also observed that the increased phosphorylations of p70S6K and 4EBP1, induced by exercise, were also reversed by antiĀ–IL-6 infusion (Figures 6e and f).
Phosphorylation (phosphorylations) of 4EBP1
7) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.53 Pain Relevance 0
However, comparing AICAR treated groups (control vs. exercise), exercised animals showed increases in p70S6K and 4EBP1 threonine phosphorylation of 230% and 310%, respectively (Figures 3d and e).
Phosphorylation (phosphorylation) of 4EBP1
8) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
Leptin induced p70S6K and 4EBP1 threonine phosphorylation in the hypothalamus of control and exercised rats.
Phosphorylation (phosphorylation) of 4EBP1 in hypothalamus
9) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.07 Pain Relevance 0.03
Comparing leptin treated groups (control vs. exercise), in exercised animals, leptin increased both p70S6K and 4EBP1 threonine phosphorylation of 30% and 40% respectively (Figures 5d and e).
Phosphorylation (phosphorylation) of 4EBP1
10) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.09 Pain Relevance 0
AICAR reduced p70S6K and 4EBP1 threonine phosphorylation levels in the hypothalamus of control and exercised rats.
Phosphorylation (phosphorylation) of 4EBP1 in hypothalamus
11) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03
Comparing fasting groups (control vs. exercise), exercised animals showed increases in p70S6K and 4EBP1 threonine phosphorylation of 261% and 240%, respectively (Figures 3n and o).
Phosphorylation (phosphorylation) of 4EBP1
12) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.07 Pain Relevance 0.07
Exercised animals pretreated with Rapamycin also reduced hypothalamic p70S6K and 4EBP1 phosphorylation (Figures 8d and e).
Phosphorylation (phosphorylation) of 4EBP1
13) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
6 M) to rats pretreated with AICAR reduced both p70S6K and 4EBP1 phosphorylation levels in the hypothalamus.
Phosphorylation (phosphorylation) of 4EBP1 in hypothalamus
14) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
6 M) to exercised rats pretreated with vehicle induced p70S6K and 4EBP1 phosphorylation in the hypothalamus of 60% and 70%, respectively, compared with the control group.
Phosphorylation (phosphorylation) of 4EBP1 in hypothalamus
15) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.05 Pain Relevance 0
After SDS-PAGE (15% resolving gels for phospho-4EBP1 and 4EBP1; 12% resolving gels for phospho-AMPK, AMPK?
Phosphorylation (phospho) of 4EBP1
16) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.07 Pain Relevance 0.07
To determine the effects of exercise on AMPK-mTOR signaling pathway, leptin was i.c.v. administered and AMPK, ACC, p70S6K and 4EBP1 phosphorylation levels were assessed in the hypothalamus of all rats.
Phosphorylation (phosphorylation) of 4EBP1 in hypothalamus
17) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03
We used insulin as a mitogenic stimulus because of the important role of hyperinsulinemia in the development of neointimal hyperplasia, the concomitant inducer of translation initiation factor activity (phosphorylation of 4EBP-1 and P70S6K), and critical cell cycle regulators downstream of mTOR.
Phosphorylation (phosphorylation) of 4EBP-1 associated with hyperinsulinism and hyperplasia
18) Confidence 0.05 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.38 Pain Relevance 0.09
Insulin and angiotensin II are known to activate the PI3K/Akt/mTOR/P70S6K pathways and to phosphorylate 4E-BP1.13-15
Phosphorylation (phosphorylate) of 4E-BP1
19) Confidence 0.05 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.31 Pain Relevance 0.05
activation reduces mitogen-induced VSMC growth by inhibition of Akt activity and increase of phosphorylated forms of 4E-BP1.
Phosphorylation (phosphorylated) of 4E-BP1
20) Confidence 0.05 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0 Pain Relevance 0.04

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