INT77227

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Context Info
Confidence 0.05
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 2.44
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Anatomy Link Frequency
hypothalamus 2
adipocytes 2
Eif4ebp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 10 98.32 Very High Very High Very High
Potency 2 94.00 High High
agonist 28 93.36 High High
Intracerebroventricular 30 88.08 High High
Enkephalin 4 85.36 High High
MU agonist 4 75.44 Quite High
Morphine 4 72.08 Quite High
antagonist 2 65.76 Quite High
Analgesic 2 63.68 Quite High
cytokine 10 54.92 Quite High
Disease Link Frequency Relevance Heat
Hyperplasia 16 99.64 Very High Very High Very High
Hyperinsulinism 4 98.74 Very High Very High Very High
Obesity 246 98.56 Very High Very High Very High
Apoptosis 2 90.24 High High
Cardiovascular Disease 8 82.88 Quite High
Appetite Loss 84 72.20 Quite High
Adhesions 4 57.32 Quite High
INFLAMMATION 12 54.52 Quite High
Neointima 44 50.40 Quite High
Diabetes Mellitus 28 46.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It had been demonstrated that the sequence of events between the activation of Akt and increased phosphorylation of 4E-BP1 involves the activation of mTOR signaling.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of 4E-BP1
1) Confidence 0.05 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.05 Pain Relevance 0.05
It had been demonstrated that the sequence of events between the activation of Akt and increased phosphorylation of 4E-BP1 involves the activation of mTOR signaling.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of 4E-BP1
2) Confidence 0.05 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.05 Pain Relevance 0.05
However, comparing AICAR treated groups (control vs. exercise), exercised animals showed increases in p70S6K and 4EBP1 threonine phosphorylation of 230% and 310%, respectively (Figures 3d and e).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of 4EBP1
3) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
We also observed that the increased phosphorylations of p70S6K and 4EBP1, induced by exercise, were also reversed by anti–IL-6 infusion (Figures 6e and f).
Positive_regulation (increased) of Phosphorylation (phosphorylations) of 4EBP1
4) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.53 Pain Relevance 0
-LA increased p70S6K and 4EBP1 threonine phosphorylation of 19% and 11%, respectively (Figures 4d and e). ?
Positive_regulation (increased) of Phosphorylation (phosphorylation) of 4EBP1
5) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.05 Pain Relevance 0.07
6 M) to exercised rats pretreated with vehicle induced p70S6K and 4EBP1 phosphorylation in the hypothalamus of 60% and 70%, respectively, compared with the control group.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of 4EBP1 in hypothalamus
6) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.05 Pain Relevance 0
Comparing fasting groups (control vs. exercise), exercised animals showed increases in p70S6K and 4EBP1 threonine phosphorylation of 261% and 240%, respectively (Figures 3n and o).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of 4EBP1
7) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.07 Pain Relevance 0.07
activation reduces mitogen-induced VSMC growth by inhibition of Akt activity and increase of phosphorylated forms of 4E-BP1.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of 4E-BP1
8) Confidence 0.03 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0 Pain Relevance 0.04
We used insulin as a mitogenic stimulus because of the important role of hyperinsulinemia in the development of neointimal hyperplasia, the concomitant inducer of translation initiation factor activity (phosphorylation of 4EBP-1 and P70S6K), and critical cell cycle regulators downstream of mTOR.
Positive_regulation (inducer) of Phosphorylation (phosphorylation) of 4EBP-1 associated with hyperinsulinism and hyperplasia
9) Confidence 0.03 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.44 Pain Relevance 0.12
We also observed that the increased phosphorylations of p70S6K and 4EBP1, induced by exercise, were also reversed by anti–IL-6 infusion (Figures 6e and f).
Positive_regulation (induced) of Phosphorylation (phosphorylations) of 4EBP1
10) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.54 Pain Relevance 0
Several amino acids that are structurally related to leucine strongly stimulated 4E-BP1 phosphorylation at concentrations greater than the EC(50) value for leucine.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of 4E-BP1
11) Confidence 0.01 Published 2000 Journal J. Cell. Biochem. Section Abstract Doc Link 10723090 Disease Relevance 0.24 Pain Relevance 0.15
In adipocytes, amino acids stimulate the target of rapamycin (TOR) signaling pathway leading to phosphorylation of the translational repressor, eIF-4E binding protein-I (4E-BP1), and ribosomal protein S6.
Positive_regulation (leading) of Phosphorylation (phosphorylation) of 4E-BP1 in adipocytes associated with obesity
12) Confidence 0.01 Published 2000 Journal J. Cell. Biochem. Section Abstract Doc Link 10723090 Disease Relevance 0.26 Pain Relevance 0.03
Consistent with these findings, DAMGO-stimulated phosphorylation of 4E-BP1 impairs its ability to bind the translation initiation factor eIF-4E.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of 4E-BP1
13) Confidence 0.00 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9722592 Disease Relevance 0.07 Pain Relevance 0.42
DAMGO also stimulates the phosphorylation of two other downstream effectors of PI3K, the p70 S6 kinase and the repressors of mRNA translation, 4E-BP1 and 4E-BP2.
Positive_regulation (stimulates) of Phosphorylation (phosphorylation) of 4E-BP1
14) Confidence 0.00 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9722592 Disease Relevance 0.09 Pain Relevance 0.67

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