INT7723

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Context Info
Confidence 0.46
First Reported 1992
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.28
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hgf) extracellular space (Hgf) cell morphogenesis (Hgf)
Anatomy Link Frequency
HGF 7
hepatocytes 1
fibroblast 1
ganglia 1
Hgf (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 8 88.92 High High
ischemia 1 81.84 Quite High
imagery 73 80.72 Quite High
agonist 4 79.48 Quite High
antagonist 2 75.00 Quite High
guanethidine 1 74.44 Quite High
psoriasis 1 34.32 Quite Low
Arthritis 1 33.88 Quite Low
anesthesia 15 25.00 Low Low
peripheral neuropathy 1 6.76 Low Low
Disease Link Frequency Relevance Heat
Cancer 1197 99.76 Very High Very High Very High
Obesity 31 94.44 High High
Bronchospasm 4 89.76 High High
Apoptosis 28 87.24 High High
Acute Liver Failure 22 84.28 Quite High
Injury 49 82.48 Quite High
Aggression 36 82.24 Quite High
Cv Unclassified Under Development 1 81.84 Quite High
Poisoning 8 64.00 Quite High
Wound Healing 22 60.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AT-SCs secrete angiogenic molecules, including HGF, VEGF, PlGF, IGF, and KGF [11, 12].
Localization (secrete) of HGF in HGF
1) Confidence 0.46 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 0.63 Pain Relevance 0.04
Growth factors stain in patches that do not correlate with the more sparse staining patterns of the TAF markers themselves due to the fact that the tumor cells also secrete the growth factors HGF, IL-6 and EGF in the presence of MSC as demonstrated by in vitro co-culture data (Figure S4).


Localization (secrete) of HGF in HGF associated with cancer
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.30 Pain Relevance 0.04
MSC co-cultured with Skov-3 cells of Skov-3 CM secrete growth factors such as HGF, IL-6, TGF-?
Localization (secrete) of HGF in HGF
3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.49 Pain Relevance 0
, VEGF and IL-6 following 24 hour culture with Skov-3 conditioned medium (CM), while HGF secretion remains steadily expressed (Figure 4C).
Localization (secretion) of HGF in HGF
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.55 Pain Relevance 0
We confirmed the presence of HGF, EGF and IL-6 within the tumor stimulated MSC population that we identify as TAF.
Localization (presence) of HGF in HGF associated with cancer
5) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.25 Pain Relevance 0
TAF are defined as an activated fibroblast population, which is a rich source of growth factors, such as HGF and TGF?
Localization (source) of HGF in fibroblast
6) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.79 Pain Relevance 0
, VEGF and HGF secretion (Figure S4).


Localization (secretion) of HGF in HGF
7) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.51 Pain Relevance 0
Puncta of endocytosed dextran were also co-localized with junctional proteins at MCJs in HGF and InlB treated monolayers (Figure 3A, 3F).
Localization (localized) of HGF in HGF
8) Confidence 0.32 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0 Pain Relevance 0
R1 activation resulted in paracrine release of the hepatocyte growth factor (HGF), interleukin-6 (IL-6), and other hepatotrophic molecules from SEC, and the hepatocytes were stimulated to proliferate when cultured with SEC [16].
Localization (release) of HGF in hepatocytes
9) Confidence 0.31 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2933582 Disease Relevance 0.53 Pain Relevance 0
This motor response is moderated by the simultaneous stimulation of a sympathetic bronchodilating mechanism(s), possibly through activation of NK2 receptors localized in sympathetic ganglia.
Localization (localized) of NK2 in ganglia
10) Confidence 0.08 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1355435 Disease Relevance 0.22 Pain Relevance 0.60

General Comments

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