INT77246

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Context Info
Confidence 0.10
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.24
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (WNK1)
WNK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hsan 10 100.00 Very High Very High Very High
Osteoarthritis 1 97.64 Very High Very High Very High
Peripheral nervous system 1 93.04 High High
abdominal pain 1 83.00 Quite High
Pain 1 81.20 Quite High
Peripheral nerve injury 1 73.24 Quite High
peripheral neuropathy 1 57.60 Quite High
Disease Link Frequency Relevance Heat
Hereditary Sensory And Autonomic Neuropathies 16 100.00 Very High Very High Very High
Pressure And Volume Under Development 14 100.00 Very High Very High Very High
Aggression 1 99.52 Very High Very High Very High
Cognitive Disorder 2 98.52 Very High Very High Very High
Osteoarthritis 1 97.64 Very High Very High Very High
Infection 1 95.12 Very High Very High Very High
Fever 2 94.24 High High
Neurodegenerative Disease 1 91.72 High High
Diabetic Nephropathy 1 88.20 High High
Abdominal Pain 1 83.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have also investigated NOR1 and several other characterized genes that localize to chromosome 9q22 for a pathogenic role in HSN-I.
Positive_regulation (role) of HSN-I
1) Confidence 0.10 Published 1998 Journal Genomics Section Abstract Doc Link 9722951 Disease Relevance 0.53 Pain Relevance 0.16
Four missense mutations (C133W, C133Y, V144D and G387A) in SPTLC1 were reported to cause HSAN I.
Positive_regulation (cause) of HSAN I associated with hereditary sensory and autonomic neuropathies
2) Confidence 0.10 Published 2009 Journal Neurogenetics Section Abstract Doc Link 19132419 Disease Relevance 0.67 Pain Relevance 0.21
Our results rule out a mutation in the translated region of the ninjurin gene as a cause of HSN type I and type II.
Positive_regulation (cause) of HSN type I associated with hsan
3) Confidence 0.07 Published 1999 Journal Am. J. Med. Genet. Section Abstract Doc Link 10232753 Disease Relevance 0.59 Pain Relevance 0.55
HSAN4 is caused by mutations in the NTRK1 gene coding for the tyrosine kinase receptor A.
Positive_regulation (caused) of HSAN4
4) Confidence 0.05 Published 2008 Journal Neuromuscul. Disord. Section Abstract Doc Link 18657423 Disease Relevance 0.89 Pain Relevance 0.13
OK-432 was highly stimulatory for TNF-alpha production of ascites cells compared with other biological response modifiers of PSK and LEM.
Positive_regulation (stimulatory) of PSK associated with pressure and volume under development
5) Confidence 0.02 Published 2006 Journal Anticancer Res. Section Abstract Doc Link 17094388 Disease Relevance 1.57 Pain Relevance 0.08

General Comments

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