INT77247

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Context Info
Confidence 0.46
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.45
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (WNK1)
Anatomy Link Frequency
liver 1
WNK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hsan 8 100.00 Very High Very High Very High
positron emission tomography 4 97.36 Very High Very High Very High
peripheral neuropathy 2 92.12 High High
palliative 6 76.24 Quite High
Peripheral nervous system 1 58.92 Quite High
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hereditary Sensory And Autonomic Neuropathies 14 100.00 Very High Very High Very High
Vomiting 2 98.20 Very High Very High Very High
Carcinoma 11 98.00 Very High Very High Very High
Erythema 1 97.88 Very High Very High Very High
Hepatotoxicity 1 97.48 Very High Very High Very High
Leukopenia 1 96.60 Very High Very High Very High
Recurrence 7 96.52 Very High Very High Very High
Toxicity 1 94.96 High High
Peripheral Neuropathy 2 92.12 High High
Deafness 1 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVES: 1) To confirm linkage of hereditary sensory neuropathy type 1 (HSN-I) to human chromosome 9q22 in a large American family of German origin. 2) To construct a yeast artificial chromosome (YAC) contig spanning the HSN-I candidate interval. 3) To investigate the HSN-I contig for potential candidate genes.
HSN-I Binding (linkage) of associated with hsan
1) Confidence 0.46 Published 1999 Journal Neurology Section Abstract Doc Link 10025779 Disease Relevance 0.17 Pain Relevance 0.17
CONCLUSIONS: Our study confirms linkage of a putative HSN-I gene to chromosome 9q22, considerably narrows the HSN-I locus, and provides a basis for identification of the HSN-I gene.


HSN-I gene Binding (linkage) of
2) Confidence 0.35 Published 1999 Journal Neurology Section Body Doc Link 10025779 Disease Relevance 0 Pain Relevance 0
Some patients randomized to PSK experienced adverse effects, including mild nausea, erythema, liver dysfunction and leukopenia, but there were no reports of toxicity that were definitely attributed to PSK.
PSK Binding (randomized) of in liver associated with toxicity, erythema, leukopenia, vomiting and hepatotoxicity
3) Confidence 0.19 Published 2004 Journal BMC Med Section Body Doc Link PMC529457 Disease Relevance 0.78 Pain Relevance 0
This indicates that the G387A mutation is most likely not directly associated with HSAN I.
HSAN I Spec (likely) Binding (associated) of associated with hereditary sensory and autonomic neuropathies
4) Confidence 0.10 Published 2009 Journal Neurogenetics Section Abstract Doc Link 19132419 Disease Relevance 0.64 Pain Relevance 0.16
This transcript map encompasses both the HSN-I critical interval and the locus for multiple self-healing squamous epithelioma (MSSE, previously named ESS1).
HSN-I Binding (interval) of associated with carcinoma
5) Confidence 0.08 Published 1998 Journal Genomics Section Abstract Doc Link 9722951 Disease Relevance 0.67 Pain Relevance 0.20
We combined PSK with FOLFOX/FOLFIRI because we expected PSK to enhance the efficacy of these chemotherapies.
PSK Binding (combined) of
6) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2917439 Disease Relevance 1.18 Pain Relevance 0.17

General Comments

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