INT7725

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Context Info
Confidence 0.67
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 3.62
Pain Relevance 4.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hgf) extracellular space (Hgf) cell morphogenesis (Hgf)
Anatomy Link Frequency
HGF 2
spinal cord 1
dura mater 1
PGE2 1
neural 1
Hgf (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 99.76 Very High Very High Very High
Spinal cord 7 99.60 Very High Very High Very High
Kinase C 3 99.42 Very High Very High Very High
qutenza 22 99.40 Very High Very High Very High
Inflammation 9 98.84 Very High Very High Very High
substance P 22 98.44 Very High Very High Very High
antagonist 15 97.40 Very High Very High Very High
agonist 15 97.36 Very High Very High Very High
substantia gelatinosa 4 97.28 Very High Very High Very High
Inflammatory response 1 90.08 High High
Disease Link Frequency Relevance Heat
Bronchospasm 8 99.82 Very High Very High Very High
Neurogenic Inflammation 4 98.84 Very High Very High Very High
Cancer 199 98.72 Very High Very High Very High
Wound Healing 29 98.64 Very High Very High Very High
Stress 15 98.60 Very High Very High Very High
Cicatrix 1 93.00 High High
Targeted Disruption 3 89.56 High High
Injury 75 89.44 High High
Pain 4 87.04 High High
Pressure And Volume Under Development 9 83.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our observations provide new insights on the processing of sensory neurotransmission in spinal cord, and indicate that activation of NK1 receptors is involved in the maintenance of the inhibitory tone of substantia gelatinosa interneurons.
Positive_regulation (activation) of NK1 in spinal cord associated with substantia gelatinosa and spinal cord
1) Confidence 0.67 Published 2004 Journal Pain Section Abstract Doc Link 15494183 Disease Relevance 0 Pain Relevance 0.29
These data demonstrate for the first time that acute stress triggers NI and mast cell activation in mouse dura mater through the activation of NK-1 receptors.
Positive_regulation (activation) of NK-1 in dura mater associated with stress and inflammation
2) Confidence 0.67 Published 2003 Journal Brain Res. Section Abstract Doc Link 12867261 Disease Relevance 1.23 Pain Relevance 0.79
Activation of NK1 receptors was confirmed after pre-incubation with selective NK1 antagonist L732,138 (4 microM) that consistently blocked the effects of SM-SP (nine neurons).
Positive_regulation (Activation) of NK1 in neurons associated with antagonist and substance p
3) Confidence 0.67 Published 2004 Journal Pain Section Abstract Doc Link 15494183 Disease Relevance 0.09 Pain Relevance 0.66
In conclusion, in mdx stomach the activation of NK2 receptors plays a role in the development of the tone, associated with a reduced NO production by muscular nNOS.
Positive_regulation (activation) of NK2 in stomach
4) Confidence 0.67 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16918764 Disease Relevance 0 Pain Relevance 0.29
The excitatory effect is also dependent on sensory neural pathways and requires both NK1 and NK2 receptors.
Positive_regulation (requires) of NK2 in neural
5) Confidence 0.49 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12801882 Disease Relevance 0 Pain Relevance 0.44
Collectively, these findings indicate that edematogenic responses elicited by PGE2 are mediated by EP3 receptor activation, also involving the stimulation of PLC, PKC, and MAPKs pathways and the participation of TRPV1 and NK1 receptors.
Positive_regulation (participation) of NK1 in PGE2 associated with kinase c
6) Confidence 0.49 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16644903 Disease Relevance 0.33 Pain Relevance 0.38
On the basis of our in vitro tumor growth assay data, we conclude that the MSC produced paracrine factors HGF, FGF, TGF-?
Positive_regulation (factors) of HGF in HGF associated with cancer
7) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.61 Pain Relevance 0
The cellular signaling mechanisms that regulate wound healing are complex and poorly understood, but recent findings suggest key roles for growth factors such as EGF, FGF2 and HGF, the cytokine TGF?
Positive_regulation (roles) of HGF in HGF associated with wound healing and cytokine
8) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2850366 Disease Relevance 0.90 Pain Relevance 0.09
This motor response is moderated by the simultaneous stimulation of a sympathetic bronchodilating mechanism(s), possibly through activation of NK2 receptors localized in sympathetic ganglia.
Spec (possibly) Positive_regulation (activation) of NK2 in ganglia
9) Confidence 0.07 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1355435 Disease Relevance 0.23 Pain Relevance 0.60
In summary, in anaesthetized guinea pig i.v. capsaicin-induced bronchospasm through activation of postjunctional NK2 (but not NK1) receptors along with activation of cholinergic pathways.
Positive_regulation (activation) of NK2 associated with qutenza and bronchospasm
10) Confidence 0.04 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1355435 Disease Relevance 0.24 Pain Relevance 0.72

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