INT77252

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 9.71
Pain Relevance 5.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Nr3c1) intracellular (Nr3c1) DNA binding (Nr3c1)
protein complex (Nr3c1) cytoplasm (Nr3c1) cytosol (Nr3c1)
Anatomy Link Frequency
brain 3
small intestine 3
spinal cord 1
neurons 1
medial 1
Nr3c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 10 99.92 Very High Very High Very High
Spinal cord 61 99.84 Very High Very High Very High
Eae 8 99.84 Very High Very High Very High
antagonist 12 99.44 Very High Very High Very High
fluoxetine 17 99.32 Very High Very High Very High
depression 99 99.24 Very High Very High Very High
addiction 3 99.14 Very High Very High Very High
Desipramine 8 98.92 Very High Very High Very High
opiate 4 98.92 Very High Very High Very High
antidepressant 61 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 288 99.92 Very High Very High Very High
Injury 10 99.84 Very High Very High Very High
Depression 116 99.24 Very High Very High Very High
Disease 75 99.24 Very High Very High Very High
Opiate Addiction 4 99.14 Very High Very High Very High
Multiple Sclerosis 264 98.72 Very High Very High Very High
Traumatic Stress Disorders 3 98.08 Very High Very High Very High
Carney Complex 13 97.04 Very High Very High Very High
Post-traumatic Stress Disorder 27 97.00 Very High Very High Very High
Repression 1 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, glucocorticoid receptor mRNA expression in CCI rats was increased in the medial and central amygdala, unaffected in the paraventricular nucleus, and decreased in the hippocampus.
Gene_expression (expression) of glucocorticoid receptor mRNA in medial associated with eae, hippocampus and amygdala
1) Confidence 0.67 Published 2006 Journal Physiol. Behav. Section Abstract Doc Link 16647726 Disease Relevance 1.69 Pain Relevance 1.31
Gender-related differences in the expression and functional properties of the hepatic glucocorticoid receptor were studied before and after antidepressant fluoxetine administration to both unstressed and rats exposed to a chronic social isolation stress.
Gene_expression (expression) of glucocorticoid receptor associated with stress, antidepressant and fluoxetine
2) Confidence 0.62 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20122922 Disease Relevance 0.09 Pain Relevance 0.33
Further, to investigate the mechanism of action of glucocorticoid on intestinal development, we examined the localization and expression of glucocorticoid receptor in the small intestine of rat pups.


Spec (examined) Gene_expression (expression) of glucocorticoid receptor in small intestine
3) Confidence 0.42 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0 Pain Relevance 0
Western blot analysis of the glucocorticoid receptor
Gene_expression (analysis) of glucocorticoid receptor
4) Confidence 0.37 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0 Pain Relevance 0
Furthermore, expression and localization of glucocorticoid receptor in the small intestine were determined.
Gene_expression (expression) of glucocorticoid receptor in small intestine
5) Confidence 0.33 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0.08 Pain Relevance 0
Localization and expression of glucocorticoid receptor in small intestine
Gene_expression (expression) of glucocorticoid receptor in small intestine
6) Confidence 0.33 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0 Pain Relevance 0
Glucocorticoid receptor expression was absent in crypts and the lamina propria.
Neg (absent) Gene_expression (expression) of Glucocorticoid receptor in lamina
7) Confidence 0.33 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0 Pain Relevance 0
Glucocorticoid receptor expression
Gene_expression (expression) of Glucocorticoid receptor
8) Confidence 0.29 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2954925 Disease Relevance 0.57 Pain Relevance 0.04
Since chronic desipramine, and not fluoxetine, is able to increase hippocampal glucocorticoid receptor (GR) expression, interactions of GR with CREB and SP1 may determine the lack of effect of desipramine on binding activity of the two latter transcription factors in this brain region. 6.
Gene_expression (expression) of glucocorticoid receptor in brain associated with desipramine and fluoxetine
9) Confidence 0.29 Published 1998 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 9723120 Disease Relevance 0.41 Pain Relevance 0.91
Expressions of Hippocampal Mineralocorticoid Receptor (MR) and Glucocorticoid Receptor (GR) in the Single-Prolonged Stress-Rats

Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experience.

Gene_expression (Expressions) of Glucocorticoid Receptor associated with mental disorders, stress, post-traumatic stress disorder and traumatic stress disorders
10) Confidence 0.25 Published 2008 Journal Acta Histochemica et Cytochemica Section Title Doc Link PMC2532603 Disease Relevance 1.34 Pain Relevance 0.10
Since hypothalamic magnocellular neurons of the adult rat express the glucocorticoid receptor [41], it is very likely that the dexamethasone effect observed here directly results from a direct repression of the VEGF gene.
Gene_expression (express) of glucocorticoid receptor in neurons associated with repression and dexamethasone
11) Confidence 0.19 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079868 Disease Relevance 0.10 Pain Relevance 0.15
Whole brain glucocorticoid receptor protein expression was reduced (approximately 70%) in morphine-treated rats 4-h after the final morphine injection and these levels recovered within 16-h.
Gene_expression (expression) of glucocorticoid receptor protein in brain associated with morphine
12) Confidence 0.16 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11679056 Disease Relevance 0.24 Pain Relevance 0.74
The effects of opiate dependence and antagonist-precipitated withdrawal on glucocorticoid (GR) and mineralocorticoid (MR) receptor mRNA levels in the rat brain were studied.
Gene_expression (levels) of glucocorticoid in brain associated with addiction, antagonist, opiate and withdrawal
13) Confidence 0.13 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559365 Disease Relevance 0.18 Pain Relevance 0.76
Depletion of HSP70 messenger ribonucleic acid has been observed in some depressed patients, but not in control subjects or in patients with other diseases.3 HSP70 is also known to control the glucocorticoid receptor (GR), which is known to play a role in depression.4,5
Gene_expression (known) of glucocorticoid receptor associated with depression and disease
14) Confidence 0.09 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC2848765 Disease Relevance 0.79 Pain Relevance 0.10
Analysis of another indicator of HPA axis activity and regulation, glucocorticoid receptor (GR) expression, showed an increase in all groups of animals compared with their controls, 21 days after the onset of experiment (figure 1D; F: 14,74, dF: 7), indicating a normal regulation of the HPA axis.


Gene_expression (expression) of glucocorticoid receptor
15) Confidence 0.06 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.21 Pain Relevance 0.07
Moreover, glucocorticoid receptor expression in spinal cord is lower in the EAE+S group at 12 days than in the control group, indicating a possible dysregulation of HPA feedback regulation (high levels of corticosterone not correlated with increased expression of GR) which indicates that hypofunction of the axis increases vulnerability and severity of EAE.
Gene_expression (expression) of glucocorticoid receptor in spinal cord associated with multiple sclerosis and spinal cord
16) Confidence 0.06 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.38 Pain Relevance 0.26
Antidepressant drugs have been suggested to exert their clinical action via a facilitation of glucocorticoid receptor gene expression and function in the HPA (Brady et al 1991).
Gene_expression (expression) of glucocorticoid receptor associated with antidepressant
17) Confidence 0.05 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654524 Disease Relevance 0.51 Pain Relevance 0.52
This delayed paradoxical response was associated with an increased expression of the glucocorticoid receptor (GR); its molecular basis still remains to be clarified [11].
Gene_expression (expression) of glucocorticoid receptor
18) Confidence 0.05 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2923167 Disease Relevance 1.04 Pain Relevance 0.07
in MCF-7 cells [71] and we developed a similar story on the expression of the membrane glucocorticoid receptor [72,73] in lymphoid tissues.
Gene_expression (expression) of membrane glucocorticoid receptor in lymphoid tissues
19) Confidence 0.01 Published 2006 Journal J Mol Signal Section Body Doc Link PMC1769494 Disease Relevance 0 Pain Relevance 0

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