INT77253

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Context Info
Confidence 0.03
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.40
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) pigmentation (gr) mitochondrion (Creb1)
nucleolus (Creb1) nucleus (Creb1) DNA binding (Creb1)
Anatomy Link Frequency
brain 1
gr (Mus musculus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 4 98.50 Very High Very High Very High
Desipramine 6 98.20 Very High Very High Very High
Hippocampus 4 93.80 High High
antidepressant 4 81.04 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 5 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since chronic desipramine, and not fluoxetine, is able to increase hippocampal glucocorticoid receptor (GR) expression, interactions of GR with CREB and SP1 may determine the lack of effect of desipramine on binding activity of the two latter transcription factors in this brain region. 6.
GR Binding (interactions) of CREB in brain associated with desipramine and fluoxetine
1) Confidence 0.03 Published 1998 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 9723120 Disease Relevance 0.40 Pain Relevance 0.90

General Comments

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