INT77256

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Context Info
Confidence 0.40
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.52
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Crhr1) response to stress (Crhr1) signal transducer activity (Crhr1)
Anatomy Link Frequency
nucleus 4
colons 2
proximal 2
Crhr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 1 100.00 Very High Very High Very High
Intracerebroventricular 1 99.98 Very High Very High Very High
Enkephalin 1 99.18 Very High Very High Very High
qutenza 2 95.68 Very High Very High Very High
corticosteroid 4 87.72 High High
dexamethasone 4 78.28 Quite High
spastic colon 3 75.00 Quite High
Action potential 1 61.72 Quite High
tetrodotoxin 1 60.32 Quite High
sodium channel 1 48.68 Quite Low
Disease Link Frequency Relevance Heat
Stress 17 99.64 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

13 99.60 Very High Very High Very High
Sprains And Strains 2 89.52 High High
Pressure Volume 2 Under Development 2 88.40 High High
Functional Bowel Disorder 3 75.00 Quite High
Adrenal Insufficiency 1 34.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure to open field (OF) and colorectal distension (CRD) stressors induced decreased protein expression of CRFR1 in SD proximal colons, an effect that was blunted in WKYs.
Negative_regulation (decreased) of Gene_expression (expression) of CRFR1 in colons
1) Confidence 0.40 Published 2010 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19807869 Disease Relevance 0.56 Pain Relevance 0.06
Moreover, decreases in expression of CRFR1 in the proximal and distal colon of NS rats following exposure to CRD were blunted in MS rats.
Negative_regulation (decreases) of Gene_expression (expression) of CRFR1 in proximal
2) Confidence 0.37 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.28 Pain Relevance 0.07
Direct inhibitory effect of glucocorticoids on corticotrophin-releasing hormone gene expression in neurones of the paraventricular nucleus in rat hypothalamic organotypic cultures.
Negative_regulation (effect) of Gene_expression (expression) of corticotrophin-releasing hormone in nucleus
3) Confidence 0.36 Published 2008 Journal J. Neuroendocrinol. Section Title Doc Link 18624927 Disease Relevance 0.09 Pain Relevance 0.27
In contrast, distal CRFR1 and CRFR2 levels were higher in MS rats but were significantly reduced post OF stress.
Negative_regulation (reduced) of Gene_expression (levels) of CRFR1 associated with stress
4) Confidence 0.27 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.29 Pain Relevance 0.07
Corticosterone can facilitate as well as inhibit corticotropin-releasing hormone gene expression in the rat hypothalamic paraventricular nucleus.
Negative_regulation (inhibit) of Gene_expression (expression) of inhibit corticotropin-releasing hormone gene in nucleus associated with enkephalin
5) Confidence 0.24 Published 1998 Journal Endocrinology Section Title Doc Link 9724036 Disease Relevance 0.16 Pain Relevance 0.10
Intracerebroventricular injection of CRF type 1 and type 2 receptor antagonists prevented the effects of obestatin on gastroduodenal motility.
Negative_regulation (prevented) of Gene_expression (injection) of CRF type 1 associated with antagonist and intracerebroventricular
6) Confidence 0.16 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18325980 Disease Relevance 0 Pain Relevance 0.20

General Comments

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