INT77258

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Context Info
Confidence 0.54
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.93
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SAA1)
Anatomy Link Frequency
plasma 1
superior 1
SAA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 98.16 Very High Very High Very High
Crohn's disease 35 95.56 Very High Very High Very High
Paracetamol 13 82.40 Quite High
antagonist 1 52.48 Quite High
Inflammation 17 50.00 Quite Low
spastic colon 24 30.80 Quite Low
Pain score 1 25.00 Low Low
metalloproteinase 3 12.72 Low Low
rheumatoid arthritis 28 5.00 Very Low Very Low Very Low
methotrexate 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 6 100.00 Very High Very High Very High
Disease 86 99.76 Very High Very High Very High
Pancreatitis 7 96.52 Very High Very High Very High
Inflammatory Bowel Disease 83 95.28 Very High Very High Very High
Amyloidosis 3 94.92 High High
Rheumatic Diseases 3 93.36 High High
Fever 1 72.40 Quite High
Fatigue 1 70.96 Quite High
Infection 6 59.60 Quite High
Mycobacterial Infection 4 51.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Variations in plasma sulfur amino acid (SAA) pools are associated with disease risks, but little information is available about the factors affecting plasma SAA pools.
Regulation (affecting) of SAA in plasma associated with disease
1) Confidence 0.54 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20207721 Disease Relevance 0.10 Pain Relevance 0.36
The influence of the clinical course on procalcitonin (PCT), serum amyloid A (SAA), and several proinflammatory and inhibitory cytokines was evaluated in patients with AP following ERCP.
Regulation (influence) of SAA associated with pancreatitis, alzheimer's dementia and cytokine
2) Confidence 0.44 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9724166 Disease Relevance 0.79 Pain Relevance 0.08
Spearman correlation coefficients were used to explore the association of S100A12 with SAA and CRP values, CDAI and CAI, as well as disease duration.
Regulation (values) of SAA associated with disease
3) Confidence 0.16 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 0.54 Pain Relevance 0.09
Furthermore, since the capacity of tocilizumab to normalize values of CRP and SAA is clearly superior to that of TNF inhibitors (Hagiwara et al 2004, 2005; Okuda et al 2007), the advantage in treatment of AA amyloidosis, a serious complication of rheumatic diseases (Okuda et al 2006) should be emphasized.
Regulation (values) of SAA in superior associated with amyloidosis and rheumatic diseases
4) Confidence 0.09 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.50 Pain Relevance 0

General Comments

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