INT77281

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 132
Total Number 134
Disease Relevance 102.78
Pain Relevance 5.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HIVEP1) intracellular (HIVEP1) DNA binding (HIVEP1)
cytoplasm (HIVEP1)
Anatomy Link Frequency
plasma 13
arms 6
T cells 6
cleavage 2
CSF 1
HIVEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 229 100.00 Very High Very High Very High
antagonist 126 100.00 Very High Very High Very High
drug abuse 126 99.90 Very High Very High Very High
chemokine 159 99.80 Very High Very High Very High
Potency 138 99.64 Very High Very High Very High
Leflunomide 108 99.16 Very High Very High Very High
methadone 159 99.04 Very High Very High Very High
Nerve growth factor 4 98.40 Very High Very High Very High
Enkephalin 3 97.04 Very High Very High Very High
Opioid 7 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 9990 100.00 Very High Very High Very High
Infection 3077 100.00 Very High Very High Very High
Hepatitis C Virus Infection 183 100.00 Very High Very High Very High
Disease Progression 144 99.96 Very High Very High Very High
Malaria 68 99.96 Very High Very High Very High
Leishmaniasis 16 99.92 Very High Very High Very High
Drug Dependence 127 99.90 Very High Very High Very High
Parkinson's Disease 10 99.64 Very High Very High Very High
Lymphadenopathy 8 99.52 Very High Very High Very High
Death 221 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, downregulation of h-GAAP causes cell death by apoptosis, and v-GAAP can complement for loss of h-GAAP to promote cell survival.


Negative_regulation (loss) of h-GAAP associated with apoptosis and death
1) Confidence 0.49 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.33 Pain Relevance 0
Therefore, downregulation of h-GAAP causes cell death by apoptosis, and v-GAAP can complement for loss of h-GAAP to promote cell survival.


Negative_regulation (downregulation) of h-GAAP associated with apoptosis and death
2) Confidence 0.49 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.32 Pain Relevance 0
A VACV mutant lacking the GAAP gene was constructed using a plasmid assembled by splicing by overlap extension (SOE)-PCR [35].
Negative_regulation (lacking) of GAAP
3) Confidence 0.42 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.05 Pain Relevance 0
HIV-1 infection of microglial cell cultures induced the release of quinolinate, and U50,488 dose-dependently suppressed quinolinate release by infected microglial cell cultures with a corresponding inhibition of HIV-1 p24 antigen levels.
Negative_regulation (inhibition) of HIV-1 p24 in microglial cell associated with acquired immune deficiency syndrome or hiv infection and infection
4) Confidence 0.40 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10665828 Disease Relevance 1.03 Pain Relevance 0.33
Standard interventions for prevention of mother-to-child transmission (PMTCT) can significantly reduce HIV transmission in infants [2].
Negative_regulation (reduce) of HIV associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.37 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2365974 Disease Relevance 1.11 Pain Relevance 0
The close relationship between the viral and the human proteins was confirmed in that v-GAAP could complement for the loss of h-GAAP and promote cell survival.
Negative_regulation (loss) of h-GAAP
6) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1803007 Disease Relevance 1.54 Pain Relevance 0
GAAP siRNA1 was designed to down-regulate h-GAAP and v-GAAP, whereas GAAP siRNAs 2 and 3 were specific for h-GAAP.
Negative_regulation (regulate) of v-GAAP
7) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.14 Pain Relevance 0
GAAP siRNA1 was designed to down-regulate h-GAAP and v-GAAP, whereas GAAP siRNAs 2 and 3 were specific for h-GAAP.
Negative_regulation (down) of h-GAAP
8) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.14 Pain Relevance 0
GAAP siRNA1 was designed to down-regulate h-GAAP and v-GAAP, whereas GAAP siRNAs 2 and 3 were specific for h-GAAP.
Negative_regulation (regulate) of h-GAAP
9) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.14 Pain Relevance 0
RT-PCR showed that GAAP siRNAs 1 and 3 down-regulated h-GAAP mRNA substantially by 36 h post transfection, whereas GAAP siRNA2 and a control siRNA against GFP did not (Figure 4A).
Negative_regulation (down-regulated) of h-GAAP
10) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.16 Pain Relevance 0
Conversely, knockout of h-GAAP by siRNA induced cell death by apoptosis. v-GAAP and h-GAAP display overlapping functions as shown by the ability of v-GAAP to complement for the loss of h-GAAP.
Negative_regulation (loss) of h-GAAP associated with targeted disruption, apoptosis and death
11) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1803007 Disease Relevance 1.47 Pain Relevance 0
Within 2 weeks of starting highly active antiretroviral therapy (HAART), all symptoms except lymphadenopathy were resolved, and the serum HIV-1 RNA level dramatically decreased to 5011 copies/ml, eventually becoming undetectable by the standard method.
Negative_regulation (decreased) of serum HIV-1 RNA associated with lymphadenopathy and acquired immune deficiency syndrome or hiv infection
12) Confidence 0.32 Published 2002 Journal J. Infect. Chemother. Section Abstract Doc Link 12525900 Disease Relevance 1.35 Pain Relevance 0.07
Some progress has been made, but the HIV epidemic in these areas can only be reliably reversed with full access to all parts of the country.
Negative_regulation (reversed) of HIV associated with acquired immune deficiency syndrome or hiv infection
13) Confidence 0.29 Published 2008 Journal Confl Health Section Body Doc Link PMC2330023 Disease Relevance 0.37 Pain Relevance 0
[Halpern V, Wang L, Obunge O, Ogunsola F, Mehta N, et al. (2007) Effectiveness of cellulose sulfate gel for prevention of HIV: results of the phase III trial in Nigeria. 4th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention.
Negative_regulation (prevention) of HIV associated with acquired immune deficiency syndrome or hiv infection
14) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2190795 Disease Relevance 0.94 Pain Relevance 0
Topical microbicides are products that are designed to inhibit the sexual transmission of HIV and other sexually transmitted infections (STIs). [4] Microbicides could potentially be applied vaginally to prevent both male-to-female and female-to-male transmission; by offering a female-controlled prophylactic option, a microbicide would be an important addition to the prevention toolkit.
Negative_regulation (inhibit) of HIV associated with acquired immune deficiency syndrome or hiv infection and infection
15) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2190795 Disease Relevance 1.22 Pain Relevance 0
Capacity for action by non-health ministries, critical for HIV prevention, is also weak.
Negative_regulation (prevention) of HIV associated with acquired immune deficiency syndrome or hiv infection
16) Confidence 0.22 Published 2008 Journal Confl Health Section Body Doc Link PMC2330023 Disease Relevance 0.41 Pain Relevance 0
Discussion of cultural values and roles, much of which must explore traditional norms about sexual behaviour, often for the first time in the public domain, is essential for sustainable HIV prevention.
Negative_regulation (prevention) of HIV associated with acquired immune deficiency syndrome or hiv infection
17) Confidence 0.22 Published 2008 Journal Confl Health Section Body Doc Link PMC2330023 Disease Relevance 0.58 Pain Relevance 0
The National AIDS Programme, though continuing to be based largely around health sector activities, added some non-health sector HIV prevention and awareness-raising work [9], albeit with very limited funding.
Negative_regulation (prevention) of HIV associated with acquired immune deficiency syndrome or hiv infection
18) Confidence 0.22 Published 2008 Journal Confl Health Section Body Doc Link PMC2330023 Disease Relevance 1.00 Pain Relevance 0
Continuing the provision of key HIV prevention and care services for the people of Myanmar remained the unifying motivator.
Negative_regulation (prevention) of HIV associated with acquired immune deficiency syndrome or hiv infection
19) Confidence 0.22 Published 2008 Journal Confl Health Section Body Doc Link PMC2330023 Disease Relevance 0.21 Pain Relevance 0
Characteristics of the broader operating environment also hamper, rather than facilitate, HIV prevention and care.
Negative_regulation (prevention) of HIV associated with acquired immune deficiency syndrome or hiv infection
20) Confidence 0.22 Published 2008 Journal Confl Health Section Body Doc Link PMC2330023 Disease Relevance 0.52 Pain Relevance 0

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