INT77282

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 23
Total Number 35
Disease Relevance 21.80
Pain Relevance 9.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Cftr) enzyme binding (Cftr) molecular_function (Cftr)
protein complex (Cftr) transmembrane transport (Cftr) cytoplasm (Cftr)
Anatomy Link Frequency
poly 2
epithelial cells 2
sweat 1
Cftr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 330 100.00 Very High Very High Very High
Chronic pancreatitis 70 99.96 Very High Very High Very High
Prostatitis 884 98.40 Very High Very High Very High
Inflammation 406 98.40 Very High Very High Very High
cytokine 170 97.88 Very High Very High Very High
anesthesia 2 95.24 Very High Very High Very High
isoflurane 2 94.80 High High
Inflammatory response 26 82.56 Quite High
tetrodotoxin 1 47.68 Quite Low
agonist 28 43.16 Quite Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 330 100.00 Very High Very High Very High
Pancreatitis 131 99.96 Very High Very High Very High
Bacterial Infection 299 99.06 Very High Very High Very High
Benign Prostatic Hypertrophy 39 98.96 Very High Very High Very High
Pulmonary Disease 29 98.82 Very High Very High Very High
Hyperplasia 26 98.80 Very High Very High Very High
Prostatitis 884 98.40 Very High Very High Very High
INFLAMMATION 432 98.40 Very High Very High Very High
Disease 94 97.44 Very High Very High Very High
Constipation 156 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Superfusion of CFTR(inh)-172 (0.1-10 microM) over the duodenal mucosa had no effect on basal DBS but at 10 microM inhibited acid-induced DBS, suggesting that its effect was limited to CFTR activation.
Positive_regulation (activation) of CFTR
1) Confidence 0.69 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.92 Pain Relevance 0.33
On the other hand, when pancreatic inflammation was present, the levels of CFTR and carbonic anhydrase were increased, indicating ductal and/or centroacinar cell involvement.
Positive_regulation (increased) of CFTR
2) Confidence 0.67 Published 2006 Journal Pancreas Section Body Doc Link 17079941 Disease Relevance 0 Pain Relevance 0
As elucidated in several studies, CFTR activation is normally regulated by ATP release, elevation of cytosolic cAMP [26] and protein kinase A (PKA).
Positive_regulation (activation) of CFTR
3) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553183 Disease Relevance 0 Pain Relevance 0
transport by upregulating CAII and CFTR.
Positive_regulation (upregulating) of CFTR
4) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.95 Pain Relevance 0.51
What is the physiological significance of the upregulation of CFTR and the possible enhanced CFTR-mediated prostatic HCO3?
Spec (possible) Positive_regulation (upregulation) of CFTR-mediated
5) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.81 Pain Relevance 0.47
One important observation made in this study is the upregulation of CFTR and CAII, along with several important inflammatory cytokines, upon E. coli-LPS challenge in vitro or E. coli infection in vivo.
Positive_regulation (upregulation) of CFTR associated with inflammation, infection and cytokine
6) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.53 Pain Relevance 0.17
What is the physiological significance of the upregulation of CFTR and the possible enhanced CFTR-mediated prostatic HCO3?
Spec (possible) Positive_regulation (upregulation) of CFTR
7) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.80 Pain Relevance 0.46
Superfusion of CFTR(inh)-172 (0.1-10 microM) over the duodenal mucosa had no effect on basal DBS but at 10 microM inhibited acid-induced DBS, suggesting that its effect was limited to CFTR activation.
Positive_regulation (Superfusion) of CFTR
8) Confidence 0.50 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.92 Pain Relevance 0.36
Almost universally they had at least one Class IV or Class V CFTR mutation, which results in levels of CFTR function estimated to be about 10% of normal [16].
Positive_regulation (results) of CFTR
9) Confidence 0.50 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 0.68 Pain Relevance 0.18
This should include not only a standard diagnostic work-up, including a sweat chloride and radiologic screening for subtle lung disease, but also nasal potential difference measures in order to evaluate CFTR at a physiologic level, and screening for mild and rare CFTR mutations [10].
Positive_regulation (evaluate) of CFTR in sweat associated with pulmonary disease
10) Confidence 0.50 Published 2001 Journal Respir Res Section Body Doc Link PMC64805 Disease Relevance 1.02 Pain Relevance 0.13
Recent reports [5,6,15,16] suggest that patients with an ICP phenotype have an increased incidence of mutations in CFTR.
Positive_regulation (increased) of CFTR associated with chronic pancreatitis
11) Confidence 0.50 Published 2001 Journal Respir Res Section Body Doc Link PMC64805 Disease Relevance 1.41 Pain Relevance 0.68
In the present study, it is most likely that the long-lasting ISC response to NAR was mediated through cAMP signaling pathways which then activates the apical CFTR channels and basolateral K+ channels.
Positive_regulation (activates) of CFTR
12) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553183 Disease Relevance 0.09 Pain Relevance 0
BACKGROUND/AIMS: Mutations in the gene encoding the cystic fibrosis transmembrane regulator (CFTR) are over-represented in patients with chronic pancreatitis: 13-37% of pancreatitis patients are heterozygous for CFTR mutations, compared with the carrier estimate of 3.2% in the central European population.
Positive_regulation (heterozygous) of CFTR associated with fibrosis, pancreatitis, cystic fibrosis and chronic pancreatitis
13) Confidence 0.49 Published 2007 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 17943404 Disease Relevance 0.37 Pain Relevance 0.15
BACKGROUND/AIMS: Mutations in the gene encoding the cystic fibrosis transmembrane regulator (CFTR) are over-represented in patients with chronic pancreatitis: 13-37% of pancreatitis patients are heterozygous for CFTR mutations, compared with the carrier estimate of 3.2% in the central European population.
Positive_regulation (over-represented) of CFTR associated with fibrosis, pancreatitis, cystic fibrosis and chronic pancreatitis
14) Confidence 0.49 Published 2007 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 17943404 Disease Relevance 0.37 Pain Relevance 0.15
The evidence derived from present study suggests that Rut-stimulated Cl(-) secretion is mediated by generation of endogenous prostaglandin E(2) and that it also involves the stimulation of cAMP and protein kinase A pathways, which subsequently lead to the activation of apical Cl(-) channels, mostly the CFTR and basolateral cAMP-dependent K(+) channels.
Positive_regulation (activation) of CFTR
15) Confidence 0.48 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18187619 Disease Relevance 0.08 Pain Relevance 0.04
current was inhibited by DPC in a voltage-dependent manner (Figure 7B and C) [22], [23]; Additionally, the demonstrated ability of NAR to activate CFTR in vitro rules out the therapeutic possibility of naringenin for constipation through stimulating Cl?
Positive_regulation (activate) of CFTR associated with constipation
16) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553183 Disease Relevance 0.23 Pain Relevance 0
Eighteen patients (13.4 percent), including 12 without alcoholism, had a CFTR mutation on one chromosome, as compared with a frequency of 5.3 percent among 600 local unrelated partners of persons with a family history of cystic fibrosis (P<0.001).
Positive_regulation (had) of CFTR
17) Confidence 0.40 Published 1998 Journal N. Engl. J. Med. Section Body Doc Link 9725921 Disease Relevance 0.07 Pain Relevance 0
Previous study has found that one of the flavonoids, apigenin, could activate CFTR owing to its specific structural components [24].
Positive_regulation (activate) of CFTR
18) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553183 Disease Relevance 0.43 Pain Relevance 0
This suggests that a physiological consequence to bacterial infection or LPS challenge in the prostate would be the enhancement of the CFTR-mediated HCO3?
Positive_regulation (enhancement) of CFTR-mediated associated with bacterial infection
19) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.60 Pain Relevance 0.21
Mutations in the CFTR gene are known to cause cystic fibrosis (CF), a lethal genetic disease found among Caucasian, which is characterized by defective Cl?
Positive_regulation (Mutations) of CFTR associated with fibrosis, cystic fibrosis and disease
20) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.75 Pain Relevance 0.33

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