INT77283

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Context Info
Confidence 0.27
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.07
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain structures 1
Thim (Mus musculus)
Thim - G20210A (1)
Pain Link Frequency Relevance Heat
opioid receptor 24 100.00 Very High Very High Very High
Hippocampus 9 96.92 Very High Very High Very High
Pain 3 95.32 Very High Very High Very High
Central grey 27 94.88 High High
antagonist 2 92.00 High High
cva 1 91.92 High High
opiate 2 91.20 High High
cINOD 1 82.56 Quite High
aspirin 1 82.00 Quite High
GABAergic 1 77.28 Quite High
Disease Link Frequency Relevance Heat
Cancer 7 99.60 Very High Very High Very High
Convulsion 1 96.60 Very High Very High Very High
Urological Neuroanatomy 27 94.88 High High
Thrombosis 1 94.40 High High
Spontaneous Abortion 1 92.72 High High
Hemolytic Anemia 1 91.16 High High
Hypertension 1 86.00 High High
Thrombocytopenia 1 85.32 High High
Nicotine Addiction 1 81.36 Quite High
Pancreatitis 6 75.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, among women, those with a larger BMI were more likely to have a Ki-ras mutation in their tumor.
Spec (likely) Positive_regulation (have) of mutation associated with cancer
1) Confidence 0.27 Published 2001 Journal Mutat. Res. Section Abstract Doc Link 11600135 Disease Relevance 0.90 Pain Relevance 0.12
Distinct response of MORs in the DG to THIM treatment may be due to different functional role of these receptors in the hippocampus than in other brain structures.
Positive_regulation (response) of THIM in brain structures associated with hippocampus and opioid receptor
2) Confidence 0.18 Published 2010 Journal Neurochem Res Section Body Doc Link PMC2957583 Disease Relevance 0.42 Pain Relevance 0.83
She was then also found to have a prothrombin gene G20210A mutation.
Positive_regulation (have) of mutation (G20210A)
3) Confidence 0.02 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 17610004 Disease Relevance 0.60 Pain Relevance 0.14
Well number 94 (H10) contained DNA from a C57BL/6J mouse with a known ENU-induced heterozygous point mutation (positive control for PCR and TGCE).
Positive_regulation (induced) of mutation
4) Confidence 0.02 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1325271 Disease Relevance 0 Pain Relevance 0
Well 95 contained DNA for the same known ENU-induced mutation as well 94.
Positive_regulation (induced) of mutation
5) Confidence 0.02 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1325271 Disease Relevance 0 Pain Relevance 0
This mutation was confirmed by repeating the PCR and TGCE analysis of sample #131 (Fig. 2C), and direct DNA sequence analysis of the PCR product identified an ENU-induced A-to-G mutation in the heterozygous DNA sample (Fig. 2D).
Positive_regulation (induced) of mutation
6) Confidence 0.02 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1325271 Disease Relevance 0 Pain Relevance 0
Finally, and importantly, effects of off-target mutations can be ruled out by performing phenotype analysis in compound heterozygous mice in which the TGCE-detected ENU allele is in trans with a null mutation generated by homologous recombination in ES cells.


Positive_regulation (generated) of mutation
7) Confidence 0.02 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1325271 Disease Relevance 0 Pain Relevance 0
None had a mutation on both copies of the CFTR gene.
Positive_regulation (had) of mutation
8) Confidence 0.00 Published 1998 Journal N. Engl. J. Med. Section Body Doc Link 9725921 Disease Relevance 0.08 Pain Relevance 0
Eighteen patients (13.4 percent), including 12 without alcoholism, had a CFTR mutation on one chromosome, as compared with a frequency of 5.3 percent among 600 local unrelated partners of persons with a family history of cystic fibrosis (P<0.001).
Positive_regulation (had) of mutation
9) Confidence 0.00 Published 1998 Journal N. Engl. J. Med. Section Body Doc Link 9725921 Disease Relevance 0.07 Pain Relevance 0

General Comments

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