INT77300

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Context Info
Confidence 0.35
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adcyap1) signal transduction (Adcyap1) extracellular space (Adcyap1)
extracellular region (Adcyap1)
Anatomy Link Frequency
pituitary 6
Adcyap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 2 100.00 Very High Very High Very High
Clonidine 3 98.66 Very High Very High Very High
narcan 4 98.44 Very High Very High Very High
antagonist 2 98.04 Very High Very High Very High
opioid receptor 6 97.56 Very High Very High Very High
orphanin 16 95.24 Very High Very High Very High
agonist 1 92.64 High High
Morphine 6 76.24 Quite High
Neuropeptide 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Suppression of effect of inhibitory neurotransmitters using pituitary adenylate cyclase activating polypeptide(6-38) (PACAP-(6-38); 3 microM), vasoactive intestinal polypeptide(10-28) (VIP-(10-28); 3 microM) and N(omega)-nitro-L-arginine methyl ester (L-NAME; 100 microM) did not influence the nociceptin-induced contractions.
Negative_regulation (Suppression) of Positive_regulation (activating) of pituitary adenylate cyclase activating polypeptide in pituitary associated with neurotransmitter and orphanin
1) Confidence 0.35 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9726656 Disease Relevance 0 Pain Relevance 0.78
Suppression of effect of inhibitory neurotransmitters using pituitary adenylate cyclase activating polypeptide(6-38) (PACAP-(6-38); 3 microM), vasoactive intestinal polypeptide(10-28) (VIP-(10-28); 3 microM) and N(omega)-nitro-L-arginine methyl ester (L-NAME; 100 microM) did not influence the nociceptin-induced contractions.
Negative_regulation (Suppression) of Positive_regulation (activating) of pituitary adenylate cyclase activating polypeptide in pituitary associated with neurotransmitter and orphanin
2) Confidence 0.35 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9726656 Disease Relevance 0 Pain Relevance 0.78
In carp pituitary cells, clonidine also suppressed cAMP production and intracellular Ca2+ levels and blocked PACAP induction of these two second messenger signals.
Negative_regulation (blocked) of Positive_regulation (induction) of PACAP in pituitary associated with clonidine
3) Confidence 0.09 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17311897 Disease Relevance 0 Pain Relevance 0.32

General Comments

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