INT77306

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Context Info
Confidence 0.58
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 46
Total Number 46
Disease Relevance 38.05
Pain Relevance 7.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)
intracellular (Bcl2) cytoplasm (Bcl2) cell proliferation (Bcl2)
Anatomy Link Frequency
MDA-MB-231 4
BT-474 3
Myocardium 2
spinal cord 2
epithelium 2
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 118 99.98 Very High Very High Very High
Spinal cord 84 99.84 Very High Very High Very High
Morphine 15 99.84 Very High Very High Very High
qutenza 10 99.84 Very High Very High Very High
rheumatoid arthritis 122 99.74 Very High Very High Very High
COX-2 inhibitor 122 99.62 Very High Very High Very High
dexamethasone 1 98.98 Very High Very High Very High
cINOD 22 98.68 Very High Very High Very High
Acupuncture 8 98.42 Very High Very High Very High
Paracetamol 10 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1658 100.00 Very High Very High Very High
Targeted Disruption 75 100.00 Very High Very High Very High
Spinal Cord Injury 122 99.88 Very High Very High Very High
Rheumatoid Arthritis 126 99.74 Very High Very High Very High
Colitis 84 99.68 Very High Very High Very High
Motor Neuron Diseases 20 99.66 Very High Very High Very High
Disease 146 99.64 Very High Very High Very High
Cancer 531 99.60 Very High Very High Very High
Necrosis 58 99.12 Very High Very High Very High
Breast Cancer 213 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Fig. 6a, Bcl-2 expression was suppressed on day 4, and almost completely inhibited on day 15, after treatment with AS Bcl-2, which was given by intraperitoneal injection every other week for 4 weeks.
Negative_regulation (suppressed) of Gene_expression (expression) of Bcl-2
1) Confidence 0.58 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.69 Pain Relevance 0
As shown in Fig. 5, treatment with AS Bcl-2 and DOX markedly suppressed Bcl-2 expression from that observed after treatment with DOX alone.
Negative_regulation (suppressed) of Gene_expression (expression) of Bcl-2
2) Confidence 0.58 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.47 Pain Relevance 0
As shown in Fig. 6a, Bcl-2 expression was suppressed on day 4, and almost completely inhibited on day 15, after treatment with AS Bcl-2, which was given by intraperitoneal injection every other week for 4 weeks.
Negative_regulation (inhibited) of Gene_expression (expression) of Bcl-2
3) Confidence 0.58 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.70 Pain Relevance 0
Furthermore, Bcl-2 expression in the B16-F10 cells was slightly down-regulated by capsaicin treatment.
Negative_regulation (down-regulated) of Gene_expression (expression) of Bcl-2 in B16-F10 associated with qutenza
4) Confidence 0.55 Published 2007 Journal Food Chem. Toxicol. Section Abstract Doc Link 17306913 Disease Relevance 0.31 Pain Relevance 0.76
EA also showed an regulatory effect on the increased the expression of CPP32 and decreased the expression of Bcl-2 by morphine.
Negative_regulation (decreased) of Gene_expression (expression) of Bcl-2 associated with acupuncture and morphine
5) Confidence 0.52 Published 2000 Journal Acupunct Electrother Res Section Abstract Doc Link 10830972 Disease Relevance 0.31 Pain Relevance 1.06
A dose–response effect with regard to downregulation of Bcl-2 protein expression was observed in ZR-75-1 and BT-474 cells, resulting in maximal inhibition approaching 50% and 70%, respectively, at concentrations up to 2.0 ?
Negative_regulation (downregulation) of Gene_expression (expression) of Bcl-2 in BT-474
6) Confidence 0.43 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.06 Pain Relevance 0
Abstinent mice also displayed a reduced expression of the antiapoptotic protein Bcl-2.
Negative_regulation (reduced) of Gene_expression (expression) of Bcl-2
7) Confidence 0.42 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16496378 Disease Relevance 0.46 Pain Relevance 0.59
Transfection of the bcl-2 gene into MDA-MB-453 cells decreased their sensitivity to DOX and MMC but not to taxanes such as TXL and TXT.
Neg (not) Negative_regulation (decreased) of Gene_expression (Transfection) of bcl-2 in MDA-MB-453
8) Confidence 0.42 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.45 Pain Relevance 0
Another influencing factor might be a difference in the ability of sequence-specific AS ODNs to suppress Bcl-2 and Bcl-xL expression.
Negative_regulation (suppress) of Gene_expression (expression) of Bcl-2
9) Confidence 0.42 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.54 Pain Relevance 0
These results indicate that the activation of Bim initiates spontaneous neutrophil apoptosis while high-level expression of Bcl-2 can block this process.
Negative_regulation (block) of Gene_expression (expression) of Bcl-2 in neutrophil associated with apoptosis
10) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2682662 Disease Relevance 2.06 Pain Relevance 0.31
Unaltered expression of BCL-X(S) in the near total absence of BCL-2 expression raises questions regarding the death promoting role of BCL-X(S) in vivo.
Negative_regulation (absence) of Gene_expression (expression) of BCL-2 associated with death
11) Confidence 0.37 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.82 Pain Relevance 0.44
Throughout the three observation time points, Bcl-2 expression levels were continuously decreasing from t = 0 hours onward, whereas Bax expression was significantly elevated at t = 24 hours and t = 72 hours when compared with t = 0 hours after hemorrhage, indicating a distinct pro-apoptotic shift (Figure 4c, left and middle).
Negative_regulation (decreasing) of Gene_expression (expression) of Bcl-2 associated with cva and apoptosis
12) Confidence 0.36 Published 2008 Journal Crit Care Section Body Doc Link PMC2374615 Disease Relevance 0.83 Pain Relevance 0.09
High levels of Bcl2 protein expression have been found in many different types of cancer, suggesting a possible role for Bcl2 deregulation of apoptosis and malignant tissue transformation.
Negative_regulation (levels) of Gene_expression (expression) of Bcl2 associated with malignant neoplastic disease, cancer and apoptosis
13) Confidence 0.36 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.45 Pain Relevance 0.03
In contrast, GW0742 treatment significantly attenuated the zymosan-induced reduction of Bcl-2 expression (Figure 16B, see densitometric analysis Figure 16B1).
Negative_regulation (reduction) of Gene_expression (expression) of Bcl-2
14) Confidence 0.31 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.17 Pain Relevance 0
Treatment of mice with 100, 200, or 400 mg/kg/day of paeonol significantly inhibited the growth of the HepA tumor in mice, induced HepA cell apoptosis as demonstrated by light microscopy and electron microscopy analyses, decreased the expression of Bcl-2 and increased the expression of Bax in HepA tumor tissues in a dose-related manner.
Negative_regulation (decreased) of Gene_expression (expression) of Bcl-2 associated with cancer and apoptosis
15) Confidence 0.31 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18329639 Disease Relevance 1.30 Pain Relevance 0.12
In this study, the decreased expression of Bcl-2, up-regulated expression of caspase-3 and Bax, as well as increased TUNEL positive cells depicted the presence of a global myocardial apoptosis following acute ethanol exposure.
Negative_regulation (decreased) of Gene_expression (expression) of Bcl-2 associated with apoptosis
16) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.74 Pain Relevance 0.08
Our analyses of HS-induced apoptotic changes in splenocytes indicated a biphasic activation of caspase-9 with a corresponding increase of pro-apoptotic Bax and repressed anti-apoptotic Bcl-2 protein expression.
Negative_regulation (repressed) of Gene_expression (expression) of Bcl-2 associated with apoptosis and hemorrhagic shock
17) Confidence 0.26 Published 2008 Journal Crit Care Section Body Doc Link PMC2374615 Disease Relevance 1.44 Pain Relevance 0.03
Notably, this defect was not transient, but persisted 35 days and 42 days postinfection with a substantial, greater than 10-fold reduction in infectious center titers between WT and the vBcl-2 mutant ?
Negative_regulation (reduction) of Gene_expression (mutant) of vBcl-2
18) Confidence 0.25 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.30 Pain Relevance 0
However, by 28 days postinfection, the titers of vBcl-2 mutant viruses, including the independently derived vBcl-2??
Negative_regulation (titers) of Gene_expression (viruses) of vBcl-2
19) Confidence 0.25 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.30 Pain Relevance 0
Twenty-four hours after SCI, the Bcl-2 expression was significantly reduced in spinal cord from SCI mice (Figure 10B; 6.57±1.4 vs. 14.62±1.4, p<0.01 vs.
Negative_regulation (reduced) of Gene_expression (expression) of Bcl-2 in spinal cord associated with spinal cord injury and spinal cord
20) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 1.92 Pain Relevance 0.34

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